Abstract
Recent clinical data in humans suggests that two types psychopathology associated with human epilepsy are anxiety and depression1,2. There is little agreement, however, regarding which type of epilepsy creates the greatest risk for interictal psychopathological complications2. Epileptics experience many life disturbances (such as illness, family and employment problems3, which are suspected precipitants of anxiety and depressive disorders4,5. Since there is no clear association between type of seizure disorder and risk for anxiety and depression, it is possible that the interictal psychopathology is a response to the stresses of being an epileptic.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
M. R. Trimble and M. M. Perez, Quantification of psychopathology in adult patients with epilepsy, in: “Epilepsy and behavior ’79,” B. M. Kulig, H. Meinardi, G. Stores, ed. Swets and Zeitlinger, Lisse (1980).
B. P. Hermann, and S. Whitman, Behavioral and personality correlates of epilepsy: a review, methodological critique, and conceptual model, Psych. Bull. 95: 451–497 (1984).
R. J. Mittan and G. E. Locke, The other half of epilepsy: psychosocial problems, Urban Health. (Jan-Feb): 38–39 (1982).
E. S. Paykel, Recent life events in the development of depressive disorder, in: “The Psychobiology of depressive disorders: Implications for the effects of stress,” E. S. Paykel ed., Academic Press, New York, (1979).
T. Takeuchi, T. Takahashi, H. Kotsuki, S. Aizawa, S. Maruyama and K. Kodama, Life events related to the inception of anxiety neurosis, Jap. J. Psychiat. Neurol. 40 (2): 137–142, (1986).
R. Adamec, Kindling, anxiety and personality, in: “The Clinical Relevance of Kindling,” M. R. Trimble and T. G. Bolwig, eds., John Wiley and Sons, Chichester, (1989) (in press).
R. Adamec and C. Stark-Adamec, Limbic kindling and animal behavior–Implications for human psychopathology associated with complex partial seizures, Biol. Psychiat. 18 (2): 269–293 (1983).
R. Adamec, Does kindling model anything clinically relevant, Biol. Psychiat. (accepted for publication) (1990).
R. Adamec, Normal and abnormal limbic system mechanisms of emotive biasing, in: “Limbic Mechanisms,” K. E. Livingston and O. Hornykiewcz, eds.,), Plenum Press, New York, (1978).
R. Adamec and C. Stark-Adamec, Partial kindling and emotional bias in the cat: Lasting after effects of partial kindling of the ventral hippocampus I Behavioral Changes, Behay. Neur. Biol. 38: 205–22 (1983).
N. Griffin, N., J. Engel and R. Sandler, Ictal and enduring interictal disturbances in emotional behavior in an animal model of temporal lobe epilepsy, Brain Res. 400: 360–364 (1987).
A. Siegel, Anatomical and functional differentiation within the amygdala, in: Modulation of Sensorimotor Activity During Alterations in Behavioral States.,“ R. Sandler, ed., Allan R. Liss, New York (1984).
P. Skolnick, P. Ninan, T. Insel, J. Crawley and S. Paul, A novel chemically induced animal model of human anxiety Psychopath. 17: 25–36 (1984).
H. Maeda, Effects of psychotropic drugs upon the hypothalamic rage responses in cats Fol. Psychiat. Neurol. Jap. 30: 539–546 (1976).
L. Wolgin, and S. Servidio Disinhibition of predatory attack in kittens by oxazepam, Soc. Neurosci. Abs. 5: 2282–0 (1979).
S. L. Stoddard, V. K. Bergdall, D. W. Towsend and B. E. Levin, Plasma catecholamine associate with hypothalamically-elicited defense behavior, Physiol. Behay. 36: 867–873 (1986).
S. L. Stoddard, V. K. Bergdall, P. S. Conn and B. E. Levin, Increases in plasma catecholamines during naturally elicited defensive behavior in the cat, J. Auton. Nerv. Sys., 19: 189–197 (1987).
M-H. Thiebot, P. Soubrie and D. Sanger, Anxiogenic properties of beta-CCE and FG 7142: a review of promises and pitfalls. Psychopharm. 94: 452–463 (1988).
R. Dorrow, R. Horowski, F. Paschelke, M. Amin and C. Braestrup, Severe anxiety induced by FG-7142, a carboline ligand for benzodiazepine receptors, Lancet 2: 98–99 (1983).
J. N. Crawley, P. T. Ninan, D. Pickar, G. P. Chrousos, M. Linnoila, P. Skolnick and S. M. Paul, Neuropharmacological antagonism of the carboline-induced “anxiety” response in rhesus monkeys, J. Neurosci. 5: 477–485 (1985).
C. Braestrup, R. Schmiechen, G. Neef, M. Nielsen and E. N. Peterson, Interaction of convulsive ligands with benzodiazepine receptors, Science 216: 1241–1242 (1982).
H. Mohler and J. G. Richards, Agonist and antagonist of benzodiazepine receptor interactions in vitro, Nature. 294: 763–765 (1981).
R. Adamec, FG-7142 and “Anxiety” in the cat: Acute and Lasting after effects. Europ. J. Pharmacol., (accepted for for publication and under revision) (1990).
R. J. Andrew, The information potentially available in mammal displays, in: “Non-verbal communication,” R. A. Hinde, ed., Cambridge University Press, London (1972).
A. Ableitner and A. Herz Changes in local cerebral glucose utilization induced by the beta-carbolines FG 7142 and DMCM reveal brain structures involved in the control of anxiety and seizure activity. J. Neurosci. 7: 1047–1055 (1987).
H. J. Little, D. J. Nutt and S. C. Taylor, Kindling and withdrawal changes at the benzodiazepine receptor, J. Psychopharmacol. 1: 35–46 (1987).
M. G. Corda, O. Giorgi, F. Gatta, and G. Biggio, Long-lasting proconflict effect induced by chronic administration of the beta-carboline derivative FG 7142. Neurosci. Lett. 62: 237–240 (1985).
é. Ongini, Behavioral and EEG effects of benzodiazepines and their antagonists in the cat. in: “Benzodiazepine recognition site ligands: Biochemistry and pharmacology,” G. Biggio and E. Costa Costa, eds., Raven Press, New York (1983).
R. Adamec and C. Stark-Adamec, Partial kindling and emotional bias in the cat: Lasting after effects of partial kindling of the ventral hippocampus. II. Physiological changes, Behay. Neur. Biol. 38: 223–239 (1983).
S. M. Pellis, D. P. O’Brien, V. C. Pellis, P. Teitelbaum, D. L. Wolgin and S. Kennedy, Escalation of feline predation along a gradient from avoidance through “play” to killing. Behay. Neurosci. 102 (5): 760–777 (1988).
J. T. Murphy, The role of the amygdala in controlling hypothalamic output. in: “The neurobiology of the amygdala,” B. E. Eleftheriou, ed., Plenum Press, New York (1972).
H. Maeda and K. Hirata, Two-stage amygdaloid lesions and hypothalamic range: A method useful for detecting functional localization, Physiol. Behay. 21: 529–530 (1978).
R. Adamec, R. The role of the amygdala and ventromedial hypothalamus in partial kindling induced increases in defensiveness in the cat, Agg. Behay. (1989) ( Accepted for publication).
R. E. Adamec and C. Stark-Adamec, Partial kindling and behavioral change-Some rules governing behavioral outcome of repeated limbic seizures, in: “Kindling 3”, J.A. Wada, ed., Raven Press, New York (1986).
R. Adamec, The relationship of the amygdala and the bed nucleus of the stria terminalis of the cat: An evoked potential and single cell study. Behay. Neur. Biol. (in press) (1989).
R. Adamec and C. Stark-Adamec, Limbic Control of Aggression, Neuro-Psychopharm. Biol. Psychiat. 7: 505–512 (1983).
R. Adamec, The effects of partial kindling on inhibition in the cat ventral hippocampus, (in preparation) (1989).
L. P. Tuff, R. J. Racine and R. Adamec, The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rat I Paired-pulse depression, Brain Res., 277: 79–90 (1983).
J. Kapur, J. L. Stringer and E. W. Lothman, Evidence that repetitive seizures in the hippocampus cause a lasting reduction of GABAergic inhibition, J. Neurophysiol. 61: 417–426 (1989).
P. G. Gluchankov, V. S. Vorobyov and V. G. Skrebitsky, Influence of carboline derivative FG7142 on the inhibition in hippocampal sections. Bull. Exp. Biol. Med. Moscow 12: 724 (1985).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Adamec, R. (1990). Kindling, Anxiety and Limbic Epilepsy: Human and Animal Perspectives. In: Wada, J.A. (eds) Kindling 4. Advances in Behavioral Biology, vol 37. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5796-4_24
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5796-4_24
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5798-8
Online ISBN: 978-1-4684-5796-4
eBook Packages: Springer Book Archive