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Mechanisms of Kindling in Developing Animals

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Kindling 4

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 37))

Abstract

Kindling was first demonstrated by Goddard and his colleagues in the late 1960s (1,2) and has since become an important animal model of partial epilepsy with secondary generalization. Kindling is most commonly achieved with the administration of repeated local subconvulsive electrical stimulations which eventually lead to the development of generalized seizures. Chemical kindling can also be demonstrated with a variety of convulsant drugs (pentylenetetrazol, lidocaine, cocaine, penicillin and carbachol) administered at subconvulsive doses (3–10). Irrespective of the type of stimulus used for the kindling process, kindling progresses in a predictable manner. The initial stimulus results in a brief focal electrical seizure or afterdischarge (AD) in the absence of any behavioral manifestations. Gradually, as the behavioral manifestations become more apparent, the ADs intensify and increase in duration. Once established, the kindling effect persists for several months suggesting that it produces permanent changes in the brain (2).

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Author information

Authors and Affiliations

  1. Departments of Neurology Neuroscience and Pediatrics Laboratory of Developmental Epilepsy, Albert Einstein College of Medicine, Bronx, N.Y., USA

    Ellen F. Sperber, Kurt Haas & Solomon L. Moshé

Authors
  1. Ellen F. Sperber
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  2. Kurt Haas
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  3. Solomon L. Moshé
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Editor information

Editors and Affiliations

  1. Neurosciences and Neurology, University of British Columbia, Vancouver, British Columbia, Canada

    Juhn A. Wada

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© 1990 Plenum Press, New York

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Sperber, E.F., Haas, K., Moshé, S.L. (1990). Mechanisms of Kindling in Developing Animals. In: Wada, J.A. (eds) Kindling 4. Advances in Behavioral Biology, vol 37. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5796-4_12

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  • DOI: https://doi.org/10.1007/978-1-4684-5796-4_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5798-8

  • Online ISBN: 978-1-4684-5796-4

  • eBook Packages: Springer Book Archive

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