Abstract
One of the most consistent findings in the literature on kindling has been the observation that the process of seizure development is facilitated by treatments that interfere with the actions of noradrenaline (NA). This body of research has given rise to the hypothesis that part of the mechanism of kindling may be a decrease in the effects of NA, produced either by a progressive suppression of the presynaptic release of NA1 or a decline in the postsynaptic response to NA2. In the present chapter we provide an update on recent evidence that NA may modulate kindling.
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© 1990 Plenum Press, New York
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Corcoran, M.E., Weiss, G.K. (1990). Noradrenaline and Kindling Revisited. In: Wada, J.A. (eds) Kindling 4. Advances in Behavioral Biology, vol 37. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5796-4_11
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DOI: https://doi.org/10.1007/978-1-4684-5796-4_11
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