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Growth Hormone Gene Expression: Hormonal Regulation and Tissue-Specific Expression

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Basic and Clinical Aspects of Growth Hormone

Part of the book series: Serono Symposia, USA ((SERONOSYMP))

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Abstract

Growth hormone (GH) belongs to a family of polypeptide hormones that includes chorionic somatomammotropin (CS, placental lactogen), prolactin (Prl) and proliferin. This hormone family is related by structural homology (1–5), immunoreactivity and partially overlapping biological functions (6). GH and Prl are essential for the normal growth and development of mammals (7,8). GH is required for statural growth and maintenance of nitrogen, mineral, lipid and carbohydrate metabolism (7). Prl is required for the initiation and maintenance of lactation (8). Proliferin may be involved in cellular growth as it occurs in increased concentrations prior to cell division (5,9). The function of CS has been postulated to provide GH-like activities for the developing fetus (10,11); however, it does not appear to have essential functions in man. It appears that a common function of the various members of the growth hormone family may be at the level of control of cellular differentiation and proliferation.

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Author information

Authors and Affiliations

  1. Metabolic Research Unit, University of California, San Francisco, CA, 94143, USA

    Norman L. Eberhardt, Linda N. Peritz, John D. Baxter, Randy Isaacs, Brian L. West & Timothy L. Reudelhuber

  2. Department of Physiology, University of Manitoba, Winnepeg, Manitoba, R3E 0W3, Canada

    Peter A. Cattini

  3. Department of Biochemistry and Biophysics, University of California, San Francisco, CA, 94143, USA

    John D. Baxter

  4. Department of Biological Sciences, University of Sydney, New South Wales, 2006, Australia

    Daniel F. Catanzaro

Authors
  1. Norman L. Eberhardt
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  2. Peter A. Cattini
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  3. Linda N. Peritz
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  4. John D. Baxter
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  5. Randy Isaacs
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  6. Daniel F. Catanzaro
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  7. Brian L. West
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  8. Timothy L. Reudelhuber
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Editor information

Editors and Affiliations

  1. University of South Florida, Tampa, Florida, USA

    Barry B. Bercu

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© 1988 Plenum Press, New York

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Eberhardt, N.L. et al. (1988). Growth Hormone Gene Expression: Hormonal Regulation and Tissue-Specific Expression. In: Bercu, B.B. (eds) Basic and Clinical Aspects of Growth Hormone. Serono Symposia, USA. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5505-2_1

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  • DOI: https://doi.org/10.1007/978-1-4684-5505-2_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5507-6

  • Online ISBN: 978-1-4684-5505-2

  • eBook Packages: Springer Book Archive

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