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Cotranslational and Posttranslational Proteolytic Processing of Preprosomatostatin-I and Preprosomatostatin-II in Intact Islet Tissue

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Somatostatin

Part of the book series: Serono Symposia, USA ((SERONOSYMP))

Abstract

Somatostatin-14 (SS-14) and somatostatin-28 (SS-28) are synthesized as part of a larger precursor, prosomatostatin. This has been demonstrated by results from experiments employing pulse-chase incubations or chemical characterization of products from intact tissue (1–9).

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Author information

Authors and Affiliations

  1. Department of Anatomy and Cell Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA

    Bryan D. Noe, Robert B. Mackin & John K. McDonald

  2. Department of Biochemistry, Purdue University, West Lafayette, IN, 47907, USA

    Philip C. Andrews & Jack E. Dixon

  3. The Salk Institute, Clayton Foundation Laboratories for Peptide Biology, La Jolla, CA, 92037, USA

    Joachim Spiess

Authors
  1. Bryan D. Noe
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  2. Robert B. Mackin
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  3. John K. McDonald
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  4. Philip C. Andrews
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  5. Jack E. Dixon
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  6. Joachim Spiess
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Editors and Affiliations

  1. Tufts University, Boston, Massachusetts, USA

    Seymour Reichlin M.D., Ph.D. (Chairman) (Chairman)

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Noe, B.D., Mackin, R.B., McDonald, J.K., Andrews, P.C., Dixon, J.E., Spiess, J. (1987). Cotranslational and Posttranslational Proteolytic Processing of Preprosomatostatin-I and Preprosomatostatin-II in Intact Islet Tissue. In: Reichlin, S. (eds) Somatostatin. Serono Symposia, USA. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5326-3_6

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  • DOI: https://doi.org/10.1007/978-1-4684-5326-3_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5328-7

  • Online ISBN: 978-1-4684-5326-3

  • eBook Packages: Springer Book Archive

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