Skip to main content

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 181))

Abstract

Time lapse movies of migrating T-cells remind us very much of nerve growth cones. Both sense the environment with ameboid-like processes as they seek their respective targets. The genetic, molecular and cellular basis for the production of the specificity on B-cells and T-cells is understood to an extraordinary degree at this point in history. On the other hand, the specificity found on cells in the developing nervous system is only understood at the level of descriptive biology.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Boveri, T. (1904). Ergebnisse uber die Konstitution der chromatischen Subotany des Zellkerns. Verlag von Gustav Fischer in Jena.

    Book  Google Scholar 

  • Dreyer, W. J. and Bennett, J. C. (1965). The molecular basis of antibody formation: A paradox. Proc. Natl. Acad. Sci. USA 54: 864–869.

    Article  PubMed  CAS  Google Scholar 

  • Dreyer, W. J., Gray, W. and Hood, L. (1967). The genetic molecular, and cellular basis of antibody formation: Some facts and a unifying hypothesis. Cold Spring Harbor Symp. Quant. Biol. 32: 353–367.

    Article  CAS  Google Scholar 

  • Dreyer, W. J. and Gray, W. R. (1968). On the role of nucleic acids as genes conferring precise chemospecificity to differentiated cell lines.: “Nucleic Acids in Immunology,” O. J. Plescia and W. Braun, eds. Springer-Verlag, New York, pp. 614–643.

    Google Scholar 

  • Dreyer, W. J. (1984). Molecular evolution antibody formation and embryogenesis. In “The Impact of Protein Chemistry on The Biomedical Sciences,” A. N. Schechter, A. Dean, R. F. Goldberger, eds. Academic Press, New York, pp. 137–157.

    Chapter  Google Scholar 

  • Gurdon, J. B., and Laskey, R. A. (1970). The transplantation of nuclei from single cultured cells into enucleate frogs eggs. J. Embryol. Exp. Morphol. 24: 227–248.

    PubMed  CAS  Google Scholar 

  • Hedrick, S. M., Cohen, D. I., Nielsen, E. A., and Davis, M. M. (1984a). Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature 308: 149–153.

    Article  PubMed  CAS  Google Scholar 

  • Hedrick, S. M., Nielsen, E. A., Kavaler, J., Cohen, D. I., and Davis, M. M. (1984b). Sequence relationships between putative T cell receptor polypeptides and immunoglobulins. Nature 308: 153–158.

    Article  PubMed  CAS  Google Scholar 

  • Hood, L., Huang, H. V. and Dreyer, W. J. (1977). The area code hypothesis: The immune system provides clues to understanding the genetic and molecular basis of cell recognition during development. J. Supramol. Struct. 7: 531–559.

    Article  PubMed  CAS  Google Scholar 

  • Horvitz, R. H. (1981) Neuronal Cell Lineages in the Nematode Caenorhabditis elegans In: “Readings in Developmental Neurobiology” Patterson, P. H. and Purves, D., Eds. Cold Spring Harbor Laboratory, p. 140–155.

    Google Scholar 

  • Huang, H., and Dreyer, W. J. (1978). Bursectomy in ovo blocks the generation of immunoglobulin diversity. J. Immunol. 121: 1738–1747.

    PubMed  CAS  Google Scholar 

  • Hunkapiller, M., Kent, S., Caruthers, M., Dreyer, W., Firca, J., Giffin, C., Horvath, S., Hunkapiller, T., Tempst, P., and Hood, L. (1984). A microchemical facility for the analysis and synthesis of genes and proteins. Nature (in press).

    Google Scholar 

  • Leder, P. (1982). The genetics of antibody diversity. Scientific American 246: 102–115.

    Article  PubMed  CAS  Google Scholar 

  • McKinnell, R. G. (1978). “Cloning: Nuclear Transplantation in Amphibia” University of Minnesota Press, p. 134–147.

    Google Scholar 

  • Wabl, M. R., Brun, R. B., and DuPasquier, L. (1975) Lymphocytes of the toad Xenopus laevis have the gene set for promoting tadpole development. Science 190: 1310–1312.

    Article  PubMed  CAS  Google Scholar 

  • Yanagi, Y., Yoshikai, Y., Leggett, K., Clark, S. P., Alksander, I., and Mak, T. W. (1984). A human T-cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. Nature 308: 145–149.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Plenum Press, New York

About this chapter

Cite this chapter

Dreyer, W.J., Roman, J.M. (1984). Immunology and Embryogenesis: The Chromosomal Editing Hypothesis. In: Lauder, J.M., Nelson, P.G. (eds) Gene Expression and Cell-Cell Interactions in the Developing Nervous System. Advances in Experimental Medicine and Biology, vol 181. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4868-9_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4868-9_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4870-2

  • Online ISBN: 978-1-4684-4868-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics