Abstract
As early as 1909 Elliott1 proposed that an adrenaline-like substance is released from sympathetic nerve terminals to produce a chemical neurotransmission. Since then, various chemical neurotransmitters have been identified. The classical chemical neurotramsnitters, catecholamines (CA), serotonin (5HT), acetylcholine (ACh) and gamma-aminobutyric acid (GABA), are most venerable neurotransmitters.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
T.R. Elliot, The action of adrenaline, J. Physiol. (London) 32:401 (1905).
W.W. Douglas, Stimulus-secretion coupling: the concept and clues from chromaffin and other cells, Brit. J. Pharmacol. Chemother. 34:451 (1968).
R.M. Weinshelboum, N.B. Thoa, D.G. Johnson, I.J. Kopin, and J. Axelrod, Proportional release of norepinephrine and dopamine B-hydroxylase from sympathetic neurons, Science 174:1349 (1971).
T.H. Joh and M. Goldstein, Isolation and characterization of multiple forms of phenylethanolamine N-methyltransferase, Mol. Pharmacol. 9:117 (1973).
T.H. Joh and M.E. Ross, Preparation of catecholamine-synthesizing enzymes as immunogens for immunohistochemistry, in: “Immunohistochemistry,” vol. 3, A.C. Cuello, ed., John Wiley & Sons, Ltd., Chichester (1983).
T.H. Joh, D.H. Park, and D.J. Reis, Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: a mechanism of enzyme activation, Proc. Natl. Acad. Sci. USA 75: 4744 (1978).
M.E. Ross, D.H. Park, G. Teitelman, V.M. Pickel, D.J. Reis, and T.H. Joh, Immunohistochemical localization of choline acetyltransferase using a monoclonal antibody: a radioautographic method, Neuroscience 10(3):907 (1983).
E.E. Baetge, B.B. Kaplan, D.J. Reis, and T.H. Joh, Translation of tyrosine hydroxylase from Poly(A)mRNA in pheochromocytoma cells (PC12) is enhanced by dexamethasone, Proc. Natl. Acad. Sci. USA 78:1269 (1981).
T.H. Joh, C. Geghman, and D.J. Reis, Immunochemical demonstration in increased accumulation of tyrosine hydroxylase protein in sympathetic ganglia and adrenal medulla elicited by reserpine, Proc. Natl. Acad. Sci. USA 70:2767 (1973).
T. Lewander, T.H. Joh, and D.J. Reis, Tyrosine hydroxylase: delayed activation in central noradrenergic neurons and induction in adrenal medulla elicited by stimulation of central cholinergic receptors, J. Pharmacol. Exp. Ther. 200:523 (1977).
D.J. Reis, T.H. Joh, and R.A. Ross, Effects of reserpine on activities and amounts of tyrosine hydroxylase and dopamine-B-hydroxylase in catecholaminergic neuronal systems in rat brain, J. Pharmacol. Exp. Ther. 193:775 (1975).
R.A. Ross, T.H. Joh, and D.J. Reis, Increase in the relative rate of synthesis of dopamine-B-hydroxylase in the nucleus locus coeruleus elicited by reserpine, J. Neurochem. 31:1491 (1978).
R.A. Ross, T.H. Joh, and D.J. Reis, Reduced rate of biosynthesis of dopamine-B-hydroxylase in the nucleus locus coeruleus during the retrograde reaction, Brain Res. 160:174 (1979).
T.H. Joh, E.E. Baetge, M.E. Ross, and D.J. Reis, Evidence for the existence of homologous gene coding regions for the catecholamine biosynthetic enzymes, in: “Cold Spring Harbor Symposia on Quantitative Biology,” vol. 48, J.D. Watson, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor (1983).
B. Petrack, F. Sheppy, and V. Fetzer, Studies on tyrosine hydroxylase from bovine adrenal medulla, J. Biol. Chem. 243:743 (1968).
D.H. Park, E.E. Baetge, B.B. Kaplan, V.R. Albert, D.J. Reis, and T.H. Joh, Different forms of adrenal phanylethanolamine N-methyl-transferase: species-specific posttranslational modification, J. Neurochem. 38:410 (1982).
P.H. Seeburg, H. Shine, J.A. Martial, A. Urlich, J.D. Baxter, and H.M. Goodman, Nucleotide sequence of part of the gene for human chorionic somatomatropin: purification of DNA complementary to predominant mRNA species, Cell 12:157 (1977).
E.E. Baetge, H.M. Moon, B.B. Kaplan, D.H. Park, D.J. Reis, and T.H. Joh, Identification of clones containing DNA complementary to phenylethanolamine N-methyltransferase mRNA, Neurochem. Intl. 5(5):611 (1983).
J. Abelson, RNA processing and the intervening sequence problem, Ann. Rev. Biochem. 48:1035 (1979).
R. Breathnach and P. Chambon, Organization and expression of Eucaryotic split genes coding for proteins, Ann. Rev. Biochem. 50:349 (1981).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Plenum Press, New York
About this chapter
Cite this chapter
Joh, T.H. (1984). Genomic and Phenotypic Expression of Autonomic Neurons. In: Lauder, J.M., Nelson, P.G. (eds) Gene Expression and Cell-Cell Interactions in the Developing Nervous System. Advances in Experimental Medicine and Biology, vol 181. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4868-9_5
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4868-9_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4870-2
Online ISBN: 978-1-4684-4868-9
eBook Packages: Springer Book Archive