Abstract
One neuroblastoma and four hybrid cell lines were obtained which formed numerous synapses with cultured striated muscle cells. Many other neuroblastoma or somatic cell hybrids were found which synthesized acetylcholine, but which lacked one or more properties needed to form functional synapses. The following kinds of clonally inherited synaptic defects were identified in these cell lines: alterations in voltage-sensitive Ca2+ channel activity, large dense-core vesicles, depolarization-dependent acetylcholine secretion, and the lack of functional protein synthesized and released into the medium by the neural cells (which normally Increases aggregation of nicotinic acetylcholine receptors on myotube plasma membranes).
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© 1984 Plenum Press, New York
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Nirenberg, M., Krueger, K., Rotter, A., Wilson, S., Higashida, H. (1984). Regulation of Synapse Formation by Cyclic AMP. In: Lauder, J.M., Nelson, P.G. (eds) Gene Expression and Cell-Cell Interactions in the Developing Nervous System. Advances in Experimental Medicine and Biology, vol 181. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4868-9_2
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DOI: https://doi.org/10.1007/978-1-4684-4868-9_2
Publisher Name: Springer, Boston, MA
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