Abstract
The role of cell-cell interactions in morphogenesis and differentiation of neural cells and tissues has been increasingly the focus of considerable research activity (especially in recent years). One of the most popular model systems for investigating these problems is the embryonic neural retina. It is widely accepted that interactions between heterotypic cells in the retina influence various developmental processes (Moscona, 1974; Moscona & Linser, 1983). Our studies have addressed specifically the role of cell interactions in regulating the expression of developmentally programmed gene products. Since the avian retina is avascular, biochemical and other studies on this tissue are not complicated by the presence of non-neural cells. Also, since the avian retina contains only one kind of neuroglia, Muller cells (Cajal, 1973), it is possible to investigate the influence of retinal neurons on gene expressions in the glial cell compartment. In this paper, we review some of our observations concerning the role of neuron-glia interactions in regulating the expression of specific gene products which are sequestered in the glial compartment of the mature retina.
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References
Aquayo, J. J., Epps, J., Charron, L. and Bray, G. M., 1976, Multipotentiality of Schwann cells in cross-anastomosed and grafted myelinated and unmyelinated nerves. Brain Res., 104: 1–20.
Cajal, S. R., 1973, in “The Vertebrate Retina”, R. W. Rodieck (ed)., W. H. Freeman and Company, pp. 838–852.
Colowick, S. P. and N. O. Kaplan, 1975, Hormone Action, Part D: Isolated Cells, Tissues and Organ Systems, in “Methods in Enzymology” Vol. 39, J. G. Hardman and B. W. O’Malley (eds.), Academic Press, New York, 39.
Fisher, M., 1984, Neuronal-glial interactions and glial enzyme expression in the mouse cerebellum, in “Gene Expression and Cell-Cell Interactions in the Developing Nervous System”, J. Lauder and P. Nelson (eds.), Plenum Publishing Corp.
Hamberger, A. C., Han Chaing, G., Nylen, E. S., Scheff, S. W. and C. W. Cotman, 1979, Glutamate as a CNS transmitter. I. Evaluation of glucose and glutamine as precursors for the synthesis of preferentially released glutamate, Brain Res. 168: 513–530.
Hausman, R. E. and A. A. Moscona, 1976, Isolation of retina-specific cell-aggregating factor from membranes of embryonic neural retina tissue, Proc Natl. Acad. Sci. USA 73: 3594–98.
Holton, B. and J. Weston, 1982, Analysis of glial cell differentiation in peripheral nervous tissue. H. Neurons promote S-100 synthesis by purified glial precursor cell populations. Develop. Biol. 89: 72–81.
Kahn, A. J., 1974, An autoradiographic analysis at the time of appearance of neurons in the developing chick neural retina, Develop. Biol. 38: 30–40.
Linser, P. and A. A. Moscona, 1979, Induction of glutamine synthetase in embryonic neural retina: localization in Muller fibers and dependance on cell interactions, Proc. Natl. Acad. Sci. USA 76: 6476–6480.
Linser, P. and A. A. Moscona, 1981, Carbonic anhydrase C in the neural retina: Transition from generalized to glia-specific cell localization during embryonic development, Proc. Natl. Acad. Sci. USA 78: 7190–94.
Linser, P. J. and A. A. Moscona, 1981, Induction of glutamine synthetase in embryonic neural retina: its suppression by the gliatoxic agent alpha-aminoadipic acid, Develop, Brain Res. 1: 103–119.
Linser, P. and A. A. Moscona, 1981, Developmental changes in the distribution of S-100 in avian neural retina, Dev. Neurosci. 4: 433–441.
Linser, P. J. and A. A. Moscona, 1982, Carbonic anhydrase-C in neural retina of the chick embryo: developmental changes in cellular localization, in “Embryonic Development, Part B: Cellular Aspects”, M. Burger and R. Weber (eds.), Alan R. Liss Inc, NY, pp. 459–471.
Linser, P. and A. A. Moscona, 1983, Hormonal induction of glutamine synthetase in cultures of embryonic retina cells: requirement for neuron-glial contact interactions, Develop. Biol. 96: 529–534.
Linser, P. and A. A. Moscona, 1984, Variable CA-II compartmentalization in vertebrate retina, Ann. NY Acad. Sci.: (in press).
Linser, P. J., Sorrentino, M., and A. A. Moscona, 1984, Cellular compartmentalization of carbonic anhydrase-C and glutamine synthetase in developing and mature mouse neural retina, Develop. Brain Res.: (in press).
Maren, T., 1967, Carbonic anhydrase: chemistry, physiology and inhibition, Physiol Rev. 47: 595–781.
Maren, T. H., 1976, The rates of movement of Na+, CI- and HCO3 - from plasma to posterior chamber: effect of acetazolamide and relation to the treatment of glaucoma, Invest. Ophthal. 15: 356–364.
Moscona, A. A., 1972, Induction of glutamine synthetase in embryonic neural retina: a model for the regulation of specific gene expression in embryonic cells, F.E.B.S. Proc. 24: 1–23.
Moscona, A. A., 1974, Surface specification of embryonic cells: lectin receptors, cell recognition, and specific cell ligands, in “The Cell Surface in Development”, A. A. Moscona (ed.), John Wiley & Sons, NY, pp. 67–99.
Moscona, A. A. and P. Linser, 1983, Developmental and experimental changes in retina glia cells: cell interactions and control of phenotype expression and stability, Curr. Top. Dev. BioL 18: 155–188.
Moscona, M. and A. A. Moscona, 1979, Malformation of embryonic neural retina elicited by BrdU, Differentiation 13: 173–184.
Moscona, A. A. and R. Piddington, 1966, Stimulation by hydrocortisone of premature changes in the developmental pattern of glutamine synthetase in embryonic retina, Biochim. Biophys. Acta 121: 409–411.
Olney, J. W., Ho, O. L. and V. Rhee, 1971, Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system, Exp. Brain Res. 14: 61–76.
Olney, J. W., Rhee, V. and O. L. Ho, 1974, Kainic acid: a powerful neurotoxic analogue of glutamate, Brain Res. 77: 507.
Pedersen, O. O. and R. L. Karlsen, 1979, Destruction of Muller cells in the adult rat by intravitreal injection of D, L- -aminoadipic acid. An electron microscopic study, Exp. Eye Res. 28: 569–575.
Piddington, R., and A. A. Moscona, 1965, Correspondence between glutamine synthetase activity and differentiation in the embryonic retina in situ and in culture, J. Cell. Biol. 27: 247–252.
Reif-Lehrer, L., 1981, Effects of kainic acid on glutamine synthetase activity in isolated chick embryo retina, Supple Inves. Ophthalmol. Vis. Sci. 20: 215.
Schwarcz, R. and J. T. Coyle, 1977, Kainic acid: neurotoxic effects after intraocular injection, Invest. Ophthalmol. Vis. Sci. 16: 141–148.
Stewart, R. M. and R. N. Rosenberg, 1979, Physiology of glia: glial-neuronal interactions, Inter. Rev. Neuro. 21: 275–309.
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© 1984 Plenum Press, New York
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Linser, P.J., Moscona, A.A. (1984). The Influence of Neuronal-Glial Interactions on Glia-Specific Gene Expression in Embryonic Retina. In: Lauder, J.M., Nelson, P.G. (eds) Gene Expression and Cell-Cell Interactions in the Developing Nervous System. Advances in Experimental Medicine and Biology, vol 181. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4868-9_15
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DOI: https://doi.org/10.1007/978-1-4684-4868-9_15
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