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Immunogenicity of Endotoxin

  • Chapter
Beneficial Effects of Endotoxins

Abstract

Endotoxin or lipopolysaccharide (LPS) is one of the most extraordinary bacterial products because of the variety of biologic effect it engenders in susceptible animals. Some of these reactions are undesirable, since they may be associated with pathologic changes and even with death. Others are beneficial when the result is enhanced resistance or immunity to toxemia and/or infection. It must be emphasized, however, that, depending upon the degree of reaction and the particular circumstances, one and the same effect may be either beneficial or harmful. Thus, high fever may have undesirable results or, as utilized some time ago, may be curative when used in patients to cure certain diseases or to enhance resistance. Pyrogenicity has been studied for more than two centuries, as reviewed in depth by Westphal et al. (1977). Similarly, an immune response to a given antigenic determinant may have either beneficial, harmful, or indifferent effects.

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  1. Departments of Microbiology and Pediatrics, State University of New York at Buffalo, Buffalo, New York, 14222, USA

    Erwin Neter

  2. Laboratory of Bacteriology, Children’s Hospital, Buffalo, New York, 14222, USA

    Erwin Neter

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  1. Erwin Neter
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  1. Center for Oral Health Research, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

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Neter, E. (1983). Immunogenicity of Endotoxin. In: Nowotny, A. (eds) Beneficial Effects of Endotoxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4364-6_4

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