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Effect of LPS On the Clotting System

  • Chapter
Beneficial Effects of Endotoxins

Abstract

The activation of the clotting system is one of the body’s natural defense mechanisms. In addition to the formation of a fibrin clot that seals an injured vessel, other systems are triggered such as fibrinolytic, kinin, and complement. As a consequence, several mediators are produced that are involved in nonspecific resistance to infections and tumors.

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References

  • Aasen, A. O., Frolich, W., Sangstad, O. D., and Amundsen, E., 1978a, Plasma kallikrein activity and prekallikrein levels during endotoxin shock in dogs, Eur. Surg. Res. 10:50.

    Article  PubMed  CAS  Google Scholar 

  • Aasen, A. O., Ohlsson, K., Larsbraaten, M., and Amundsen, E., 1978b, Changes in plasminogen levels, plasmin activity and activity of antiplasmins during endotoxin shock in dogs, Eur. Surg. Res. 10:63.

    Article  PubMed  CAS  Google Scholar 

  • Abdelnoor, A. M., Kassem, H., Bikhazi, A. B., and Nowotny, A., 1980, Effect of gramnegative bacterial lipopolysaccharide derived polysaccharides, glycolipids, and lipopolysaccharides on rabbit and human platelets in vitro, Immunobiology 157:145.

    Article  PubMed  CAS  Google Scholar 

  • Abdelnoor, A. M., Johnson, A. G., Anderson-Imbert, A., and Nowotny, A., 1981, Immunization against bacteria- and endotoxin-induced hypotension, Infect. Immun. 32:1093.

    PubMed  CAS  Google Scholar 

  • Bjornson, H. S., and Hill, E. O., 1973, Bacteriodaceae in thromboembolic disease: Effect of cell wall components on blood coagulation in vivo and in vitro, Infect. Immun. 8:911.

    PubMed  CAS  Google Scholar 

  • Brown, D. L., and Lachmann, P. J., 1973, The behaviour of complement and platelets in lethal endotoxin shock in rabbits, Int. Arch. Allergy Appl. Immunol. 45:193.

    Article  PubMed  CAS  Google Scholar 

  • Chang, H., Thompson, J. J., and Nowotny, A., 1974, Release of colony stimulating factor (CSF) by non-endotoxic breakdown product of bacterial lipopolysaccharides, Immunol. Commun. 3:401.

    Google Scholar 

  • Cohen, P., and Gardner, F. M., 1966, Thrombocytopenia as a laboratory complication of gram negative bacteremic infection, Arch. Internal Med. 117:113.

    Article  CAS  Google Scholar 

  • Das, J., Schwartz, A. A., and Folkwon, J., 1973, Clearance of endotoxin by platelets: Role in increasing the accuracy of the Limulus gelation test and in combating experimental endotoxemia, Surgen 74:235.

    CAS  Google Scholar 

  • Davis, R. B., Mecker, W. R., and McQuarrie, D. C., 1960, Immediate effects of intravenous endotoxin on serotonin concentrations and blood platelets, Circ. Res. 8:234.

    PubMed  CAS  Google Scholar 

  • Davis, R. B., Mecker, W. R., and Bailey, W. L., 1961, Serotonin release after injection of E. coli endotoxins in the rabbit, Fed. Proc. 20:261.

    Google Scholar 

  • Des Prez, R. M., and Bryant, R. E., 1966, Effect of bacterial endotoxin on rabbit platelets. IV. The divalent ion requirement of endotoxin-induced and immunologically induced platelet injury,J. Exp. Med. 124:971.

    Article  PubMed  Google Scholar 

  • Des Prez, R. M., and Marney, S. R., Jr., 1971, in: The Circulating Platelets (S. A. Johnson, ed.), p. 415, Academic Press, New York.

    Google Scholar 

  • Des Prez, R. M., Horowitz, H. I., and Hook, E. W., 1961, Effect of bacterial endotoxin on rabbit platelets. I. Platelet aggregation and release of platelet factors in vitro, J. Exp. Med. 114:857.

    Article  Google Scholar 

  • Edwards, R. L., Rickles, F. R., and Babrove, A. M., 1979, Mononuclear cell tissue factor: Cell of origin and requirements for activation, Blood 54:359.

    PubMed  CAS  Google Scholar 

  • Eichenberger, E., 1955, Fibrinolyse nach intravenöser Injektion bakterieller Pyrogene, Acta Neuroveg. 11:201.

    Article  CAS  Google Scholar 

  • Fong, J. S. C., and Good, R. A., 1971, Prevention of the localized and generalized Shwartzman reaction by an anticomplementary agent: Cobra venom factors, J. Exp. Med. 134:642.

    Article  PubMed  CAS  Google Scholar 

  • Fong, J. S. C., White, J. C., and Good, R. A., 1974, Inhibition of endotoxic lipopolysaccharide-mediated platelet aggregation by cobra venom anticomplementary factor, Blood 44:399.

    PubMed  CAS  Google Scholar 

  • Gallimore, M. J., Aasen, A. O., and Amundsen, E., 1978, Changes in plasma levels of prekallikrein, kallikrein, high molecular weight kininogen and kallikrein inhibitors during lethal endotoxin shock in dogs, Haemostasis 7:79.

    PubMed  CAS  Google Scholar 

  • Galloway, R. E., Levin, J., Butler, T., et al., 1977, Activation of protein mediators of inflammation and evidence for endotoxemia in Borrelia recurrentis infection, Am. J. Med. 63:933.

    Article  PubMed  CAS  Google Scholar 

  • Garner, R., Chater, B. V., and Brown, D. L., 1974, The role of complement in endotoxic shock and disseminated intravascular coagulation: Experimental observations in the dog, Br. J. Haematol. 28:393.

    Article  PubMed  CAS  Google Scholar 

  • Hawiger, J., 1978, Platelets in Sanarelli-Shwartzman reaction and in human sepsis, in: Platelets: A Multidisciplinary Approach (G. de Gaetano and S. Garattini, eds.), p. 321, Raven Press, New York.

    Google Scholar 

  • Hawiger, J., Hawiger, A., Steckley, S., Timmons, S., and Cheng, C., 1977, Membrane changes in human platelets induced by lipopolysaccharide endotoxin, Br. J. Haematol. 35:285.

    Article  PubMed  CAS  Google Scholar 

  • Henson, P. M., 1969, The adherence of leucocytes and platelets induced by fixed IgG antibody or complement, Immunology 16:107.

    PubMed  CAS  Google Scholar 

  • Hiller, E., Saal, J. G., and Riethmueller, G., 1977, Procoagulant activity of activated monocytes, Haemostasis 6:347.

    PubMed  CAS  Google Scholar 

  • Horder, M. H., and Manrique, R., 1965, Aktivierung der Blutgerinnung durch ein bakterielles Endotoxin beim Menschen unter Kumarintherapy, Klin. Wochenschr. 43:397.

    Article  Google Scholar 

  • Humphrey, J. H., and Jacques, R., 1955, The release of histamine and 5-hydroxytryptamine (serotonin) from platelets by antigen-antibody reactions (in vitro), J. Physiol. (London) 128:9.

    CAS  Google Scholar 

  • Kane, M. A., May, J. E., and Frank, M. M., 1973, Interaction of the classical and alternate complementary pathway with endotoxin lipopolysaccharide: Effect on platelets and blood coagulation,J. Clin. Invest. 52:370.

    Article  PubMed  CAS  Google Scholar 

  • Kimball, H. R., Mclmon, K. L., and Wolfe, S. M., 1972, Endotoxin-induced kinin production in man, Proc. Soc. Exp. Biol. Med. 139:1078.

    PubMed  CAS  Google Scholar 

  • Landy, M., and Weidanz, W. P., 1964, Natural antibodies against gram negative bacteria, in: Bacterial Endotoxins (M. Landy and W. Braun, eds.), p. 275, Rutgers University Press, New Brunswick, N.J.

    Google Scholar 

  • Lerner, R. G., Goldstein, R., and Cummings, G., 1977, Endotoxin induced disseminated intravascular clotting: Evidence that it is mediated by neutrophil production of tissue factor, Thromb. Res. 11:253.

    Article  PubMed  CAS  Google Scholar 

  • Lüderitz, O., Staub, A. M., and Westphal, O., 1966, Immunochemistry of O and R antigens of Salmonella and related Enterobacteriaceae, Bactenol. Rev. 30:192.

    Google Scholar 

  • Lüscher, E. F., and Pfueller, S. L., 1978, Platelets as targets of immunological reactions, in: Platelets: A Multidisciplinary Approach (G. de Gaetano and S. Garattini, eds.), p. 261, Raven Press, New York.

    Google Scholar 

  • Mason, J. W., Kleeberg, U., Dolan, P., and Colman, R. W., 1970, Plasma kallikrein and Hageman factor in gram negative bacteremia, Ann. Intern. Med. 73:545.

    PubMed  CAS  Google Scholar 

  • Michael, J. G., Whitby, J. L., and Landy, M., 1962, Studies on natural antibodies to gram negative bacteria,J. Exp. Med. 115:3.

    Article  Google Scholar 

  • Morrison, D. C., and Cochrane, C. G., 1974, Direct evidence for Hageman factor (factor XII) activation by bacterial lipopolysaccharides (endotoxins),J. Exp. Med. 140:797.

    Article  PubMed  CAS  Google Scholar 

  • Morrison, D. C., and Kline, L. F., 1977, Activation of the classical and properdin pathways of complement by bacterial lipopolysaccharides (LPS), J. Immunol. 118:362.

    PubMed  CAS  Google Scholar 

  • Muller-Berghans, G., 1978, Ehe role of platelets, leucocytes and complement in the activation of intravascular coagulation by endotoxins, in: Platelets: A Multidisciplinary Approach (G. de Gaetano and S. Garattini, eds.), p. 303, Raven Press, New York.

    Google Scholar 

  • Muller-Berghans, G., and Schneberger, R., 1971, Hageman factor activation in the generalized Shwartzman reaction induced by endotoxins, Br. J. Haematol, 21:513.

    Article  Google Scholar 

  • Nagayama, M., Zucker, M. B., and Beller, F. K., 1971, Effect of a variety of endotoxins on human and rabbit platelet function, Thromb. Diath. Haemorrh. 26:467.

    PubMed  CAS  Google Scholar 

  • Nowotny, A., 1969, Molecular aspects of endotoxic reactions, Bactenol. Rev. 33:72.

    CAS  Google Scholar 

  • Nowotny, A., 1971, Relation of structure and biological activity of bacterial endotoxins, Naturwissenschaften 58:397.

    Article  PubMed  CAS  Google Scholar 

  • Nowotny, A., 1977, Relation of structure to function in bacterial endotoxins, in: Microbiology 1977 (D. Schlessinger, ed.), American Society for Microbiology, Washington, D.C.

    Google Scholar 

  • Nowotny, A., Cundy, K., Neale, N., Nowotny, A. M., Radvany, R., Thomas, S., and Tripodi, D., 1966, Relation of structure to function in bacterial O-antigens. IV. Fractionation of the components, Ann. N.Y. Acad. Sci. 133:586.

    Article  PubMed  CAS  Google Scholar 

  • Nowotny, A., Behling, U. H., and Chang, H. L., 1975, Relation of structure to function in bacterial endotoxins. VIII. Biological activities in a polysaccharide-rich fraction, J. Immunol. 115:199.

    PubMed  CAS  Google Scholar 

  • Prydz, H., Allison, A. C., and Schorlemmer, H. U., 1977, Further link between complement activation and blood coagulation, Nature (London) 270:173.

    Article  CAS  Google Scholar 

  • Ream, V.J., Deykin, D., Gurewich, V., and Wessler, S., 1965, The aggregation of human platelets by bacterial endotoxins,J. Lab. Clin. Med. 66:245.

    PubMed  CAS  Google Scholar 

  • Rickles, F. R., Levine, J., Hardin, J. A., et al., 1977, Tissue factor generation by human mononuclear cells: Effects of endotoxin and dissociation of tissue factor generation from mitogenic response,J. Lab. Clin. Med. 89:792.

    PubMed  CAS  Google Scholar 

  • Rodriguez-Erdmann, F., 1964, Studies on pathogenesis of the generalized Shwartzman reaction. III. Frigger mechanism for the activation of the prothrombin molecule, Thromb. Diath. Haemorrh. 12:471.

    CAS  Google Scholar 

  • Rothberger, H., Zimmerman, T. S., Spiegelberg, H. L., and Vaughan, J. H., 1977, Leucocyte procoagulant activity: Enhancement of production in vitro by IgG and antigen-antibody complexes,J. Clin. Invest. 59:549.

    Article  PubMed  CAS  Google Scholar 

  • Semeraro, N., Colucci, M., Fumarola, D., and Vermylen, J., 1978a, Platelets and endotoxins: Complement-dependent and complement-independent interactions, in: Platelets: A Multidisciplinary Approach (G. de Gaetano and S. Garattini, eds.), Raven Press, New York.

    Google Scholar 

  • Semeraro, N., Fumarola, D., Merters, F., and Vermylen, J., 1978b, Evidence that endotoxins enhance the factor X activation activity of washed human platelets, Br. J. Haematol. 38:243.

    Article  CAS  Google Scholar 

  • Spielvogel, A. R., 1967, An ultrastructural study of the mechanism of platelet-endotoxin interaction,J. Exp. Med. 126:235.

    Article  PubMed  CAS  Google Scholar 

  • Springer, G. F., and Adye, J. C., 1975, Endotoxin-binding substances from human leucocytes and platelets, Infect. Immun. 12:978.

    PubMed  CAS  Google Scholar 

  • Tonooka, T., 1978, Development of tissue factor activity in mononuclear cells cultured in vitro, Tohoku J. Exp. Med. 125:213.

    Article  CAS  Google Scholar 

  • Ulevitch, R. J., Cochrane, C. G., Henson, P. M., Morrison, D. C., and Doc, W. F., 1975, Mediation systems in bacterial lipopolysaccharide-induced hypotension and disseminated intravascular coagulation,J. Exp. Med. 142:1570.

    Article  PubMed  CAS  Google Scholar 

  • Ulevitch, R. J., Cochrane, C. G., Bangs, K., et al., 1978, The effect of complement depletion on bacterial lipopolysaccharide induced hemodynamic and hematologic changes in the rhesus monkey, Am. J. Pathol. 92:227.

    PubMed  CAS  Google Scholar 

  • Von Kaulla, K. N., 1958, Intravenous protein-free pyrogen: A powerful fibrinolytic agent in man, Circulation 17:187.

    Google Scholar 

  • Walker, R. I., Porvaznik, M., Egan, J. E., and Miller, A. M., 1979, Hageman factor activation and tight junction disruption in mice challenged with attenuated endotoxin, Experientia 35:759.

    Article  PubMed  CAS  Google Scholar 

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© 1983 Plenum Press, New York

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Abdelnoor, A.M. (1983). Effect of LPS On the Clotting System. In: Nowotny, A. (eds) Beneficial Effects of Endotoxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4364-6_3

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  • DOI: https://doi.org/10.1007/978-1-4684-4364-6_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4366-0

  • Online ISBN: 978-1-4684-4364-6

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