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Stimulation of Nonspecific Resistance by Radiation-Detoxified Endotoxin

  • Chapter
Beneficial Effects of Endotoxins

Abstract

Many years ago, some investigators observed that within 24 hr of intravenous inoculation with killed typhoid bacilli, animals developed increased resistance to the live culture. Later, other workers identified the endotoxic lipopolysaccharides as the active material in such vaccines. The effects of this LPS-induced enhanced resistance have been demonstrated in infections induced by parasites, fungi, viruses, grampositive and gram-negative bacteria, and mycobacteria. It is also well known that repeated parenteral injections of small doses of LPS will produce endotoxin tolerance. Among the several factors that may be involved in inducing this tolerance, bacterial LPS seems to play the major role in stimulating the host’s natural defenses (Milner et al., 1971; Pusztai-Markos, 1975). This tolerance has been manifested in an immunologically nonspecific manner, where endotoxic shock could be prevented by previous applications of small doses of endotoxin or endotoxin derivatives.

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Authors and Affiliations

  1. “Frèdèric Joliot-Curie” National Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary

    Lóránd Bertók

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  1. Lóránd Bertók
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Editors and Affiliations

  1. Center for Oral Health Research, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

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© 1983 Plenum Press, New York

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Bertók, L. (1983). Stimulation of Nonspecific Resistance by Radiation-Detoxified Endotoxin. In: Nowotny, A. (eds) Beneficial Effects of Endotoxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4364-6_10

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  • DOI: https://doi.org/10.1007/978-1-4684-4364-6_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4366-0

  • Online ISBN: 978-1-4684-4364-6

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