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Galactorrhea Syndromes

  • Chapter
The Pituitary Adenoma

Abstract

With the advent of prolactin radioimmunoassay1–4 and the development of sophisticated radiological techniques for visualization of the pituitary fossa,5 it has become apparent that prolactin-producing pituitary adenomas are the most common pituitary disease seen in clinical practice.6 Patients with prolactinomas often present with galactorrhea as the cardinal symptom,7 and it has therefore become a major diagnostic dilemma to distinguish those patients who harbor adenomas from those with galactorrhea due to other causes. This chapter is designed to: (1) delineate and characterize the subgroup of galactorrhea patients with pituitary adenomas; (2) provide detailed, long-term follow-up of galactorrhea syndromes in order to define their natural history more precisely; (3) determine the influence of elevated prolactin levels on pituitary, adrenal, and ovarian function; and (4) study the etiological factors involved in galactorrhea. Results of initial study of 25 galactorrhea patients have recently been reported by our group.8 We have now had the opportunity to extend the study in a more detailed fashion to an additional 45 patients. This larger sample of 70 galactorrhea patients provided a wider variety of clinical expression of this syndrome, led to revision of standards of prolactin values associated with tumors, and modified our earlier interpretations of the significance of stimulation tests. These findings are analyzed and compared with studies of other investigators.9–12

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Author notes

  1. Bruce J. Biller

    Present address: Department of Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

  2. Aubrey Boyd III

    Present address: Department of Internal Medicine, Division of Endocrinology and Metabolism, Baylor College of Medicine, Houston, Texas, 77030, USA

Authors and Affiliations

  1. Tufts University School of Medicine, Boston, Massachusetts, 02111, USA

    Bruce J. Biller, Aubrey Boyd III, Mark E. Molitch, Kalmon D. Post & Seymour Reichlin

  2. Department of Medicine, Division of Endocrinology, Tufts-New England Medical Center Hospital, Boston, Massachusetts, 02111, USA

    Bruce J. Biller, Aubrey Boyd III, Mark E. Molitch & Seymour Reichlin

  3. Department of Neurosurgery, Tufts-New England Medical Center Hospital, Boston, Massachusetts, 02111, USA

    Kalmon D. Post

Authors
  1. Bruce J. Biller
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  2. Aubrey Boyd III
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  3. Mark E. Molitch
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  4. Kalmon D. Post
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  5. Samuel M. Wolpert
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  6. Seymour Reichlin
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Editors and Affiliations

  1. New England Medical Center Hospital, Boston, Massachusetts, USA

    Kalmon D. Post M. D. , Ivor M. D. Jackson M. D.  & Seymour Reichlin M. D., Ph. D. ,  & 

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© 1980 Plenum Publishing Corporation

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Biller, B.J., Boyd, A., Molitch, M.E., Post, K.D., Wolpert, S.M., Reichlin, S. (1980). Galactorrhea Syndromes. In: Post, K.D., Jackson, I.M.D., Reichlin, S. (eds) The Pituitary Adenoma. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3668-6_4

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  • DOI: https://doi.org/10.1007/978-1-4684-3668-6_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3670-9

  • Online ISBN: 978-1-4684-3668-6

  • eBook Packages: Springer Book Archive

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