Abstract
Adenohypophyseal hormones are frequently detectable in the cerebrospinal fluid (CSF) of patients with pituitary adenomas,1–9 especially those showing suprasellar extension (SSE).4,6,7 However, documentation of their presence in CSF of normal subjects is controversial. Some workers readily find anterior pituitary hormones in CSF,10,11 while others do not.1,4,6,7,9 It has been proposed that in the normal individual, the blood-brain barrier (BBB) is relatively impermeable to the anterior pituitary hormones and that measurable levels of these substances in the CSF of patients with pituitary tumors indicate a breakdown in the blood—CSF barrier.4,5,8 However, the possibility that adenohypophyseal hormones are normal constituents of CSF, though present below the limits of sensitivity of available assays, is not excluded. Evidence in favor of this view is provided by studies from Linfoot et al.,7 who reported that growth hormone (GH) levels in CSF of acromegalic patients without SSE correlated with the height of the plasma concentration of GH. Similar findings have also been reported for prolactin (PRL).12
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References
J.P. Allen, J.W. Kendall, R. McGilvra, T.L. Lamorena, and A. Castro, Adrenocorticotrophic and growth hormone secretion: Studies during pneumoencephalography, Arch. Neurol. 31:325–328, 1974.
J. Assies, A.P.M. Schellekens, and J.L. Touber, Prolactin secretion in patients with chromophobe adenoma of the pituitary gland, Neth. J. Med. 17:163, 1974.
J. Hardy, Trans-sphenoidal microsurgical removal of pituitary microadenoma, Prog. Neurol. Surg. 6:200, 1975.
R.M. Jordan, J.W. Kendall, J.L. Seaich, J.P. Allen, C.A. Paulsen, C.W. Kerber, and W.P. Vanderlaan, Cerebrospinal fluid hormone concentration in the evaluation of pituitary tumors, Ann. Intern. Med. 85:49–55, 1976.
J.W. Kendall, J.L. Seaich, J.P. Allen, and W.P. Vanderlaan, in: Brain-Endocrine interaction II: The Ventricular System (K.M. Knigge, D.E. Scott, J. Kobayashi, and S. Ishu, eds.), p. 313, S. Karger, Basel, 1975.
M. Kleerekoper, R.A. Donald, and S. Posen, Corticotrophin in cerebrospinal fluid of patients with Nelson’s syndrome, Lancet 1:74–76, 1972.
J.A. Linfoot, J.F. Garcia, W. Wei, R. Fink, R. Sarin, J.L. Born, and J.H. Lawrence, Human growth hormone levels in cerebrospinal fluid, J. Clin. Endocrinol. Metab. 31:230–232, 1970.
J.L. Seaich, J.P. Allen, and J.W. Kendall, Diagnostic values of CSF hormone determinations, Abstract presented at the Annual Meeting of the Endocrine Society (Abstract No. 126), June 1974.
F.J. Thomas, J.M. Lloyd, and M.J. Thomas, Radioimmunoassay of human growth hormone: Technique and application to plasma, cerebrospinal fluid and pituitary extracts, J. Clin. Pathol. 25:774–782, 1972.
J.P. Allen, J.W. Kendall, R. McGilvra, and C. Vancura, Immunoreactive ACTH in cerebrospinal fluid, J. Clin. Endocrinol. Metab. 38:586, 1974.
S. Shuster, A. Smith, N. Plummer, A. Thody, and F. Clark, Immunoreactive beta-melanocyte-stimulating hormone in cerebrospinal fluid and plasma in hypopituitarism: Evidence for an extrapituitary origin, Br. Med. J. 1:1318–1319, 1977.
J. Assies, A.P.M. Schellekens, and J.L. Touber, Prolactin in human cerebrospinal fluid, J. Clin. Endocrinol. Metab. 46(4):576, 1978.
H. Davson, Physiology of the CSF, Little, Brown, Boston, 1967.
K. Felgenhauer, Protein size and cerebrospinal fluid composition, Klin. Wochenschr. 52:1158–1164, 1974.
L.L. Schroeder, J.D. Johnson, and W.B. Malarkey, Cerebrospinal fluid prolactin: A reflection of abnormal prolactin secretion in patients with pituitary tumors, J. Clin. Endocrinol. Metab. 43:1255–1260, 1976.
C. Schaub, M.T. Bluet-Pajot, G. Szikla, C. Lornet, and J. Talairach, Distribution of growth hormone and thyroid-stimulating hormone in cerebrospinal fluid and pathological compartments of the central nervous system, J. Neurol. Sci. 13:123, 1977.
I.S. Login and R.M. MacLeod, Prolactin in human and rat serum and cerebrospinal fluid, Brain Res. 132:477–483, 1977.
R.M. Jordan, J.W. Kendall, and C.W. Kerber, The primary empty sella syndrome, Am. J. Med. 62:569–580, 1977.
R.M. Jordan, J.W. Kendall, and J.L. Seaich, CSF hormone studies in pituitary diseases, Clin. Res. 24:143A, 1976.
J. Assies, A.P.M. Schellekens, and J.L. Touber, Protein hormones in cerebrospinal fluid: Evidence for retrograde transport of prolactin from the pituitary to the brain in man, Clin. Endocrinol. 8:487–491, 1978.
K.D. Bagshawe and S. Harland, Immunodiagnosis and monitoring of gonadotrophin-producing metastases in the central nervous system, Cancer 38:112–118, 1976.
G.B. Wislocki, The vascular supply of the hypophysis cerebri of the rhesus monkey and man, Proc. Assoc. Nerv. Ment. Dis. 17:48, 1938.
W.F. Ganong and D.M. Hume, Concentration of ACTH in cavernous sinus and peripheral arterial blood in the dog, Proc. Soc. Exp. Biol. Med. 92:721, 1956.
R.M. Bergland, S.L. Davis, and R.B. Page, Pituitary secretes to brain, Lancet 11:276–278, 1977.
R.M. Bergland and R.B. Page, Can the pituitary secrete directly to the brain? (affirmative anatomical evidence), Endocrinology 102(5):1325–1338, 1978.
J. Szentagothai, B. Glerko, B. Mess, and B. Halasz, Hypothalamic control of anterior pituitary, Budapest Akad. Kiado 1968:90.
B. Torok, Structure of the vascular connections of the hypothalamohypophyseal region, Acta Anat. 59:84, 1964.
R.B. Page and R.M. Bergland, The neurohypophyseal capillary bed: Anatomy and arterial supply, Am. J. Anat. 148:345, 1977.
R.B. Page, B.L. Munger, and R.M. Bergland, Scanning microscopy of pituitary vascular casts: The rabbit pituitary portal system revisited, Am. J. Anat. 146:273, 1976.
R.D. Broadwell and M.W. Brightman, Entry of peroxidase into neurons of the central and peripheral nervous system from extra cerebral and cerebral blood, J. Comp. Neurol. 166:257, 1976.
D. Oliver, R.S. Mical, and J.C. Porter, Hypothalamic-pituitary vasculature: Evidence of retrograde blood flow in the pituitary stalk, Endocrinology 101:598, 1977.
U. Nakai and N. Naito, Uptake and bidirectional transport of peroxidase injected into the blood and cerebrospinal fluid by ependymal cells of the median eminence, in: Brain-Endocrine interaction II: The Ventricular System (K.M. Knigge, D.E. Scott, H. Kobayashi, and S. Ishi, eds.), p. 94, S. Karger, Basel, 1975.
K.M. Knigge and D.E. Scott, Structure and function of the median eminence, Am. J. Anat. 129:223, 1970.
M.G. Farquhar, Origin and fate of secretory granules in cells of the anterior pituitary gland, Trans. N. Y. Acad. Sci. 1960:347–351, 1960.
E.M. Rodriguez, in: Brain-Endocrine interaction: Median Eminence: Structure and Function (K.M. Knigge, D.E. Scott, and A. Weindl, eds.), p. 319, S. Karger, Basel, 1972.
E. Horvath and K. Kovacs, Misplaced exocytosis, Arch. Pathol. 97:221–224, 1974.
J. Hardy, Transsphenoidal microsurgery of the normal and pathological pituitary, Clin. Neurosurg. 16:185–217, 1969.
H.D. Kirgis and W. Locke, Anatomy and embryology, in: The Hypothalamus and Pituitary in Health and Disease (W. Locke and A.V. Schally, eds.), pp. 57–58, Charles C. Thomas, Springfield, Illinois, 1972.
R.M. Jordan and J.W. Kendall, Dissociation of plasma and CSF prolactin heterogeneity, Clin. Res. 24:273, 1976.
R. Luboshitzky and D. Barzilai, Suprasellar extension of tumor associated with increased cerebrospinal fluid activity of LH and FSH, Acta Endocrinol. (Copenhagen) 87(4):673–684, 1978.
W.H. Oldendorf, Blood-brain barrier permeability to drugs, Am. Rev. Pharmacol. 14:239–248, 1974.
J.W. Kendall, J.J. Jacobs, and R.M. Kramer, in: Brain-Endocrine Interaction: Median Eminence: Structure and Function (K.M. Knigge, D.E. Scott, and A. Weidl, eds.), p. 342, S. Karger, Basel, 1971.
J.G. Ondo, R.S. Mical, and J.C. Porter, Passage of radioactive substances from CSF to hypophysial portal blood, Endocrinology 91(5):1239–1246, 1971.
R.M. MacLeod and I. Login, Control of prolactin secretion by the hypothalamic catecholamines, Adv. Sex Horm. Res. 2:211–231, 1976.
M. Motta, F. Fraschini, and L. Martini, Short feedback mechanisms in the control of anterior pituitary function, in: Frontiers in Neuroendocrinology (W.F. Ganong and L. Martini, eds.), pp. 211–254, Oxford University Press, New York, 1969.
D. de Wied, Peptides and behavior, Life Sci. 20:195–204, 1977.
A.G. Frantz, Prolactin, Phys. Med. Biol. 298(4):201–207, 1978.
D. de Wied, Pituitary adrenal system hormones and behavior, Symposium on Developments in Endocrinology, In honour of Dr. G.A. Overbeek, Organon International, Oss, The Netherlands, October 1976.
A.D. Wright, M.S. McLachlan, F.H. Doyle, and T. Fraser, Serum GH levels and size of pituitary tumor in untreated acromegaly, Br. Med. J. 4:582–584, 1968.
E.J. Hanson Jr., R.H. Miller, and R.V. Randall, Suprasellar extension of tumor associated with increased cerbrospinal fluid activity of growth hormone, Mayo Clin. Proc. 51:412–416, 1976.
D.T. Krieger, A. Liotta, and M.J. Brownstein, Presence of corticotropin in limbic system of normal and hypophysectomized rats, Brain Res. 128:575–579, 1977.
J.D. Hoffman, J. Baumgartner, and E.M. Gold, Dissociation of plasma and spinal fluid ACTH in Nelson’s syndrome, J. Am. Med. Assoc. 228:491, 1974.
G.E. Shambaugh III, J.F. Wilber, E. Montoya, H. Reider, and E.R. Blonsky, Thyrotrophin-releasing hormone (TRH): Measurements in human spinal fluid, J. Clin. Endocrinol. Metab. 41(1):131–134, 1975.
J.A. Clemens and B.D. Sawyer, Identification of prolactin in cerebrospinal fluid, Exp. Brain Res. 21:399–402, 1974.
D.C. Jimerson, R.M. Post, J. Skyler, and W.E. Bunney, Prolactin in cerebrospinal fluid and dopamine function in man, J. Pharmacol. 28:845–847, 1976.
G. Sedvall, G. Alfreddson, L.B. Jerkenstedt, P. Eneroth, G. Fyro, C. Harnryd, C.G. Swahn, F.A. Weisel, and B. Wode-Helgodt, Selective effects of psychoactive drugs on levels of monoamine metabolites and prolactin in cerebrospinal fluid of psychiatric patients, Proceedings of the Sixth International Congress on Pharmacology 3:255, 1975.
B. Wode-Helgodt, P. Eneroth, B. Fyro, B. Gullberg, and G. Sedvall, Effect of chlorpromazine treatment on prolactin levels in cerebrospinal fluid and plasma of psychotic patients, Acta Psychiatr. Scand. 56(4):280–293, 1977.
S.C. Woods and D. Porte Jr., Insulin and the set-point regulation of bodyweight, in: Hunger: Basic Mechanisms and Clinical Implication (D. Novin, W. Wyrwicka, and G. Bray, eds.), p. 273, Raven Press, New York, 1976.
E.M. Rodriguez, The cerebrospinal fluid as a pathway in neuroendocrine integration, J. Endocrinol. 71:407–443, 1976.
I.S. Login, Spinal fluid prolactin (letter to the editor), Ann. Intern. Med. 86:119, 1977.
B. Biller, K.D. Post, M. Molitch, S. Reichlin, and I. Jackson, CSF pituitary hormone concentrations in patients with pituitary tumors, Abstract presented at the American Association of Neurological Surgeons Meeting, New Orleans, Louisiana (Paper No. 28), April 25, 1977.
S. Matsumura, S. Mori, H. Yoshimoto, M. Ohta, and T. Uozumi, Endocrinological evaluation of sellar and suprasellar tumor cases (the ninth report)—On the PRL levels in the CSF (author’s translation), No Shinkei Geka 5(10):1057–1063, 1977.
V.C. Caulaert, M. Aron, and J. Stahl, Sur la presence de l’hormone prehypophysaire excito-secretoire e la thyroide dans le sang et le liquide cephalorachidien et sur sa repartition dans ces milieux et dans l’urine, C. R. Soc. Biol. 106:607–609, 1931.
U. Borell, On the transport route of the thyrotropic hormone, the occurrence of the latter in different parts of the brain and its effect on the thyroidea, Acta Med. Scand. 161(Suppl.):1–227, 1945.
G. Pighini, Sulla presenza dell’ormone anteipofisario nel “tuber cinereum” nel “liquor” ven-tricolare dell’uomo, Rev. Sper. Greniatr. Med. Legale Alienaz. Ment. 56:575–622, 1932.
S.J. Watson, J.D. Barchas, and C.H. Li, Beta-lipotropin: Localization of cells and axons in rat brain by immunocytochemistry, Proc. Natl. Acad. Sci. U.S.A. 74(11):5155–5158, 1977.
L.H. Rees, ACTH, lipotropin, and MSH in health and disease, Clin. Endocrinol. Metab. 6:137–153, 1977.
R. Guillemin, Beta-lipotropin and endorphins: Implications of current knowledge, Hosp. Pract. 13:53–60, 1978.
A.G. Smith and S. Shuster, Immunoreactive beta-melanocyte-stimulating hormone in cerebrospinal fluid, Lancet 1:1321, 1976.
R.J. Carter et al., Unpublished observations.
F.E. Bloom and D. Segal, Endorphins in cerebrospinal fluid, in: Neurobiology of Cerebrospinal Fluid I (James H. Wood, ed.), Chapt. 45, Plenum Press, New York, 1980.
W.J. Davis and R. Gillette, Biologically active pituitary hormones in the rat brain amygdaloid nucleus, Science 199:804–805, 1978.
D.T. Krieger, A. Liotta, and M.J. Brownstein, Presence of corticotropin in limbic system of normal and hypophysectomized rats, Brain Res. 128:575–579, 1977.
R.L. Moldow and R.S. Yalow, Extrahypophysial distribution of thyrotropin as a function of brain size, Life Sci. 22:1859–1864, 1978.
C. Oliver and J.C. Porter, Distribution and characterization of alpha-melanocyte-stimulating hormone in the rat brain, Endocrinology 102(3):697–705, 1978.
K. Fuxe, T. Hokfelt, P. Eneroth, J.A. Gustafsson, and P. Skett, Prolactin: Localization in nerve terminals of the rat hypothalamus, Science 196:899–900, 1977.
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Post, K.D., Biller, B.J., Jackson, I.M.D. (1980). Pituitary Hormone Concentrations in Cerebrospinal Fluid in Patients with Pituitary Tumors. In: Post, K.D., Jackson, I.M.D., Reichlin, S. (eds) The Pituitary Adenoma. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3668-6_12
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DOI: https://doi.org/10.1007/978-1-4684-3668-6_12
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