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Influence of Prolonged Ethanol Intake on the Levels and Turnover of Alcohol and Aldehyde Dehydrogenases and Glutathione

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Biological Effects of Alcohol

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 126))

Abstract

In spite of much work, especially recently, much remains to be known regarding molecular aspects of acute and particularly of chronic ethanol toxicity (1,2). Much less is known, except in extreme cases, regarding methanol toxicity. Nevertheless, it is believed that acute toxicity (other than the innebriating effects similar to those resulting from ethanol which are largely due to unclarified neural mechanisms) results from acidotic effects arising from aldehyde fromation and its oxidation to formic acid. In regard to non-lethal but equally acute detrimental effects on the eye, it has been shown (3) that formaldehyde interfers with the generation of ATP during oxidative phosphorylation, which results in loss of vision.

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Author information

Authors and Affiliations

  1. Instituto de Investigaciones Citologicas, Valencia, Spain

    Consuelo Guerri & Santiago Grisolia

  2. Dept. Biochem., U. Kansas Med. Ctr., Kansas City, Kansas, USA

    Consuelo Guerri & Santiago Grisolia

Authors
  1. Consuelo Guerri
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  2. Santiago Grisolia
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Editor information

Editors and Affiliations

  1. Downstate Medical Center, Brooklyn, New York, USA

    Henri Begleiter

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© 1980 Plenum Press, New York

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Guerri, C., Grisolia, S. (1980). Influence of Prolonged Ethanol Intake on the Levels and Turnover of Alcohol and Aldehyde Dehydrogenases and Glutathione. In: Begleiter, H. (eds) Biological Effects of Alcohol. Advances in Experimental Medicine and Biology, vol 126. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3632-7_27

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  • DOI: https://doi.org/10.1007/978-1-4684-3632-7_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3634-1

  • Online ISBN: 978-1-4684-3632-7

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