Abstract
The spontaneous and evoked electrical activity of the brain as recorded by means of macroelectrodes has been extensively investigated by psychopharmacologists (see bibliography by Fink, 1964). Used as an empirical tool, it can indicate the kind of behavioral effect a new drug will have in animals or man (e.g., Itil, 1973). However, with our present inadequate understanding of the relationship between electrochemical events at the cellular level and the gross electrical activity of the brain, it is rare that specific conclusions can be drawn about the mode of action of the drug. The problems are particularly severe when the spontaneous activity of the brain is studied by conventional EEG means alone. However, when activity in specific pathways is evoked either by focal electrical stimulation or by sensory stimulation in the appropriate modality, the possibility of correlating drug effects with cellular events is enhanced. In animal experiments, by the use of intracerebral electrodes to obtain focal recordings, we can approach the optimal situation whereby only one synapse intervenes between the pathway stimulated and the neuros producing the potential we are recording. This offers the possibility of direct correlation with microelectrode studies. However, even in such a situation there are often inadequately identified variables such as drug-induced changes in background excitation or inhibition or in feedback mechanisms so that any direct action of the systemically administered drug on the synapse studied is difficult to identify.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Adey, W. R., Dunlop, C. W., Hendrix, C. E.: 1960. Hippocampal slow waves: Distribution and phase relationships in the course of approach learning, Arch. Neurol. 3: 74–90.
Adrian, E. D.: 1935. Discharge frequencies in the cerebral and cerebellar cortex, J. Physiol. 83: 32–33.
Adrian, E. D., Matthews, B. H. C.: 1934. The Berger rhythm: Potential changes from the occipital lobes of man, Brain 57: 355–385.
Aghajanian, G. K., Foote, W. E., Sheard, M. H.: 1970. Action of psychotogenic drugs on single midbrain raphe neurons, J. Pharmacol. Exp. Ther. 171: 178–187.
Akindele, M. O., Evans, J. I., Oswald, I.: 1970. Monoamine oxidase inhibitors, sleep and mood, Electroenceph. Clin. Neurophysiol. 29: 47–56.
Albe-Fessard, D., Stutinsky, F., Libouban, S.: 1966. Atlas Stéréotaxique du Diencephale du Rat Blanc, Editions du Centre National de la Recherche Scientifique, Paris.
Allison, T., Goff, W. R., Abrahamian, H. A., Rosner, B. S.: 1963. The effects of barbiturate anaesthesia upon human somatosensory evoked responses, Electroenceph. Clin. Neurophysiol. Suppl. 24: 68–75.
Andersen, P., Andersson, S. A.: 1968. The Physiological Basis of the Alpha Rhythm, Appleton-Century-Crofts, New York.
Andersen, P., Sears, T. A.: 1964. The role of inhibition in the phasing of spontaneous thalamocortical discharge, J. Physiol. 173: 459–480.
Andersen, P., Eccles, J. C., Sears, T. A.: 1964. The ventrobasal complex of the thalamus: Types of cells, their responses and their functional organization, J. Physiol. 173: 370–399.
Baldock, G., Walter, W. G.: 1946. A new electronic analyzer, Elec. Eng. 18: 339–344.
Baust, W., Niemczyk, H.: 1964. Further studies on the action of adrenergic drugs on cortical activity, Electroenceph. Clin. Neurophysiol. 17: 261–271.
Baust, W., Niemczyk, H., Vieth, J.: 1964. The action of blood pressure on the ascending reticular activating system with special reference to adrenaline-induced EEG arousal, Electroenceph. Clin. Neurophysiol. 15: 63–72.
Bell, J. A., Anderson, E. G.: 1972. The influence of semicarbazide induced depletion of y-aminobutyric acid on presynaptic inhibition, Brain Res. 43: 161–169.
Bickford, R. G., Jacobson, J. L., Cody, D. T. R.: 1964. Nature of average evoked potentials to sound and other stimuli in man, Ann. N.Y. Acad. Sci. 112: 204–223.
Bonnet, V., Bremer, F.: 1937. Action du potassium, du calcium, et de l’acétylcholine sur les activités électriques spontanés et provoquées de l’écorce cérébrale, Compt. Rend. Soc. Biol. 126: 1271–1275.
Borenstein, P., Cujo, P., Chila, M.: 1965. A propos de la classification des substances psychotropes suivant leurs effets sur l’électroencéphalogramme, Ann. Med. Psychol. 123: 429–452.
Borenstein, P., Dongier, M., Fink., M., Florio, V., Itil, T., Longo, V. G., Mellerio, F., Naquet, R., Pampiglione, G., Titera, J., Verdeaux, G.: 1970. Clinical and experimental electroencephalography, in: The Neuroleptics ( D. P. Bobon, P. A. J. Janssen, J. Bobon, eds.), pp. 109–125, Karger, Basel.
Bradley, P. B., Elkes, J.: 1957. The effect of some drugs on the electrical activity of the brain, Brain 80: 77–117.
Bradley, P. B., Hance, A. J.: 1957. The effect of chlorpromazine and methopromazine on the electrical activity of the brain in the cat, Electroenceph. Clin. Neurophysiol. 9: 191–215.
Bradley, P. B., Key, B. J.: 1958. The effects of drugs on arousal responses produced by electrical stimulation of the reticular formation of brain, Electroenceph. Clin. Neurophysiol. 10: 97–110.
Bremer, F.: 1943. Etude oscillographique des responses de l’aire acoustique corticale chez le chat, Arch. Int. Physiol. 53: 53–103.
Bremer, F.: 1952. Analyse oscillographique des résponses sensorielles des écorces cérébrales et cérébelleuse., Rev. Neurol. 87: 65–92.
Bremer, F., Chatonnet, J.: 1949. Acetylcholine et cortex cérébral, Arch. Int. Physiol. 57: 106–109.
Brooks, C. M.L., Goodwin, R. A., Willard, H. N.: 1941. The effects of various brain lesions on morphine induced hyperglycaemia and excitement in the cat, Am. J. Physiol. 133: 226–227.
Broughton, R., Regis, H., Gastaut, H.: 1965. Modifications of somaesthetic evoked potentials during bursts of mu rhythm and during fist clenching, Electroenceph. Clin. Neurophysiol. 18: 720–726.
Brown, B. B.: 1969. Effect of LSD on visually evoked responses to color in visualizer and non-visualizer subjects, Electroenceph. Clin. Neurophysiol. 27: 356–363.
Byford, G. H.: 1965. Signal variance and its application to continuous measurements of EEG activity, Proc. Roy. Soc. Lond. Ser. B 161: 421–427.
Calvet, J., Calvet, M. C., Scherrer, J.: 1964, Etude stratigraphique corticale de l’activité EEG spontanée, Electroenceph, Clin. Neurophysiol. 17: 109–125.
Carlsson, A., Lindqvist, M.: 1963. Effect of chlorpromazine or haloperidol on formation of 3-methoxytyramine and normetanephrine in mouse brain, Acta Pharmacol. Toxicol. 20: 140–144.
Celesia, G. G., Jasper, H. H.: 1966. Acetylcholine released from cerebral cortex in relation to state of excitation, Neurology 16: 1053–1064.
Consroe, P. F., White, R. P.: 1972. Effects of haloperidol and chlorpromazine on central adrenergic and cholinergic mechanisms in rabbits, Arch. Int. Pharmacodyn. 198: 67–75.
Costa, E., Pscheidt, G. R., van Meter, W. G., Himwich, H. E.: 1960. Brain concentrations of biogenic amines and EEG patterns of rabbits, J. Pharmacol. Exp. Ther. 130: 81–88.
Crawford, J. M., Curtis, D. R.: 1964. The excitation and depression of mammalian cortical neurones by amino acids, Brit. J. Pharmacol. Chemother. 23: 313–329.
Crawford, J. M., Curtis, D. R.: 1966. Pharmacological studies on feline Betz cells. J. Physiol. 186: 121–138.
Creutzfeldt, O. D., Watanabe, S., Lux, H. D.: 1966a. Relations between EEG phenomena and potentials of single cortical cells. I. Evoked responses after thalamic and epicortical stimulation. Electroenceph. Clin. Neurophysiol. 20: 1–18.
Creutzfeldt, O. D., Watanabe, S., Lux, H. D.: 1966b. Relations between EEG phenomena and potentials of single cortical cells. II. Spontaneous and convulsoid activity, Electroenceph. Clin. Neurophysiol. 20: 19–37.
Curtis, D. R., Davis, R.: 1962. Pharmacological studies upon neurones of the lateral geniculate nucleus of the cat, Brit. J. Pharmacol. 18: 217–246.
Davis, H., Mast, T., Yoshi, N., Zerlin, S.: 1966. The slow response of the human cortex to auditory stimuli recovery processes, Electroenceph. Clin. Neurophysiol. 21: 105–113.
Davis, R., Huffman, R. D.: 1968. A Stereotaxic Atlas of the Brain of the Baboon (Papio), University of Texas Press, Austin.
Dawson, G. D.: 1951. A summation technique for detecting small signals in a large irregular background, J. Physiol. 115: 2p–3 p.
Dement, W., Kleitman, N.: 1957. Cyclic variations in EEG during sleep and their relation to eye movements, body motility and dreaming, Electroenceph. Clin. Neurophysiol. 9: 673–690.
Dewhurst, W. G., Marley, E.: 1965a. Methods for quantifying behaviour and cerebral electrical activity and the effect of drugs under controlled conditions, Brit. J. Pharmacol. 25: 671–681.
Dewhurst, W. G., Marley, E.: 1965b. The effects of a-methyl derivatives of noradrenaline, phenylethylamine and tryptamine on the central nervous system of the chicken, Brit. J. Pharmacol. 25: 682–704.
Dewhurst, W. G., Marley, E.: 1965C. Action of sympathomimetic and allied amines on the central nervous system of the chicken, Brit. J. Pharmacol. 25: 705–727.
Domino, E. F., Yamamoto, K., Dren, A. T.: 1968. Role of cholinergic mechanisms in states of wakefulness and sleep, in: Anticholinergic Drugs and Brain Functions in Animals and Man, pp. 113–133, Elsevier, Amsterdam.
Dunleavy, D. L. F., Brezinova, V., Oswald, I., Maclean, A. W., Tinker, M.: 1972. Changes during weeks in effects of tricyclic drugs on the human sleeping brain, Brit. J. Psychiat. 120: 663–672.
Drohocki, Z.: 1948a. Les bases physiques de l’électro-encéphalographie quantitative, Rev. Neurol. 80: 617–618.
Drohocki, Z.: 1948b. L’integrateur de l’électroproduction cérébrale pour l’électroencephalo- graphie quantitative, Rev. Neurol. 80: 619.
Ebe, M., Meier-Ewert, K.-H., Broughton, R.: 1969. Effects of intravenous diazepam (Valium) upon evoked potentials of photosensitive epileptic and normal subjects, Electroenceph, Clin. Neurophysiol. 27: 429–435.
Eccles, J. G.: 1953. The Neurophysiological Basis of Mind, Clarendon Press, Oxford.
Eccles, J. C.: 1957. The Physiology of Nerve Cells, Johns Hopkins University Press, Baltimore.
Eccles, J. C.: 1964. The Physiology of Synapses, pp. 1–316, Springer, Berlin.
Elul, R.: 1972. The genesis of the EEG, Int. Rev. Neurobiol. 15: 227–272.
Emmers, R., Akert, K.: 1963. A Stereotaxic Atlas of the Brain of the Squirrel Monkey (Saimiri sciureus), University of Wisconsin Press, Madison.
Feldberg, W.: 1963. A Pharmacological Approach to the Brain from Its Inner and Outer Surface, Arnold, London.
Feldberg, W., Sherwood, S. L.: 1954. Injections of drugs into the lateral ventricle of the cat, J. Physiol. 123: 148–167.
Finckh, R., Kugler, J.: 1961. Quantitative Bestimmung der cerebralen Elektrogenese unter dem Einfluss von Schafmitteln und Thymoleptica, Med. Exp. 5: 370–374.
Fink, M.: 1964. A selected bibliography of electroencephalography in human psychopharmacology, 1951–1962, Electroenceph. Clin. Neurophysiol. Suppl. 23, pp. 1–68.
Fink, M.: 1969. EEG and human psychopharmacology, Ann. Rev. Pharmacol. 9: 241–258.
Florio, V., Longo, V. G.: 1971. Neuroleptic drugs and the central dopaminergic system, Neuropharmacology 10: 45–54.
Frost, J. D.: 1971. An automatic sleep analyzer, Electroenceph. Clin. Neurophysiol. 29: 88–92.
Fuxe, K.: 1965. The distribution of monoamine terminals in the central nervous system, Acta Physiol. Scand. 64:37–85 (Suppl. 247 ).
Gaillard, J. M., Krassoïevitch, M., Tissot, R.: 1972. Analyse automatique du sommeil par un système hybride: Nouveaux résultats, Electroenceph. Clin. Neurophysiol. 33: 403–410.
Gaillard, J.-M., Schulz, P., Tissot, R.: 1973. Effect of three benzodiazepines (Ni-trazepam, Fluritrazepam and bromazepam) on sleep of normal subjects, studied with an automatic sleep scoring system, Pharmacopsychiatry 6: 207–217.
Gay, P., Binnie, L. D.: 1970. An improved write-out system for low frequency wave analysers, Electroenceph. Clin. Neurophysiol. 29: 313–315.
Goldstein, L., Murphree, H., Sugerman, A. A., Pfeiffer, C. C., Jenney, E. H.: 1963a. Quantitative EEG analysis of naturally occurring and drug-induced psychotic states in human males, Clin. Pharmacol. Ther. 4: 10–21.
Goldstein, L., Murphree, H., Pfeiffer, G. C.: 1963b. Quantitative EEG in man as a measure of CNS stimulation, Ann. N.Y. Acad. Sci. 107: 1045–1056.
Haigler, H. J., Aghajanian, G. K.: 1974. Lysergic acid diethylamide and serotonin. A comparison of effects on serotoninergic input, J. Pharmacol. Exp. Ther. 188: 688–699.
Hill, R. G., Simmonds, M. A., Straughan, D. W.: 1973. Presynaptic inhibition and the depressant actions of GAB A and glycine in the feline cuneate nucleus: Changes related to electrographic seizure activity, J. Physiol. 234: 83p–84 p.
Hillarp, N. A., Fuxe, K., Dahlstróm, A.: 1966. Demonstration and mapping of central neurons containing dopamine, noradrenaline and 5-hydroxytryptamine and their reactions to psychopharmaca, Pharmacol. Rev. 18: 727–741.
Hoffman, J. S., Domino, E. F.: 1969. Comparative effects of reserpine on the sleep cycle of man and cat, J. Pharmacol. Exp. Ther. 170: 190–198.
Hókfelt, T., Lungdahl, Á., Fuxe, K., Johansson, O.: 1974. Dopamine nerve terminals in the rat limbic cortex; aspects of the dopamine hypothesis of schizophrenia, Science 184: 177–179.
Horton, R. W., Meldrum, B. S.: 1973. Seizures induced by allylglycine, 3-mercaptopropionic acid and 4-deoxypyridoxine in mice and photosensitive baboons, and different modes of inhibition of cerebral glutamic acid decarboxylase, Brit. J. Pharmacol. 49: 52–63.
Hósli, L., Tebécis, A. K., Schónwetter, H. P.: 1971. A comparison of the effects of monoamines on neurones of the bulbar reticular formation, Brain Res 25: 357–370.
Itil, T. M.: 1973. Quantitative pharmaco-electroencephalography, in: Psychotropic Drugs and the Human EEG ( T. M. Itil, ed.), Modern Problems of Pharmacopsychiatry Series, Karger, New York.
Izquierdo, I., Nasello, A. G.: 1972. Pharmacology of the brain: The hippocampus, learning and seizures, Prog. Drug Res. 16: 211–228.
Jasper, H. H.: 1958. Report of the committee on methods of clinical examination in electroencephalography, Electroenceph. Clin. Neurophysiol. 10: 370–375.
Jasper, H. H., Ajmone-Marsan, C.: 1954. A Stereotaxic Atlas of the Diencephalon of the Cat, National Research Council of Canada, Ottawa, Canada.
Jasper, H. H., Droogleever-Fortuyn, J.: 1947. Experimental studies on the functional anatomy of petit mal epilepsy, Res. Publ. Ass. New. Ment. Dis. 26: 272–298.
Jasper, H. H., Tessier, J.: 1971. Acetylcholine liberation from cerebral cortex during paradoxical (REM) sleep. Science 172: 601–602.
Johnson, E. S., Roberts, M. H. T., Straughan, D. W.: 1969. The responses of cortical neurones to monoamines under differing anaesthetic conditions, J. Physiol. 203: 261–280.
Jones, B. E.: 1969, Catecholamine-Containing Neurons in the Brain Stem of the Cat and Their Rolein Waking, pp. 1–87, Imprimerie des Beaux Arts, Lyon.
Jones, B. E., Bobillier, P., Pin, C., Jouvet, M.: 1973. The effect of lesions of catecholamine-containing neurones upon monoamine content of the brain and EEG and behavioural waking in the cat, Brain Res. 58: 157–177.
Jordan, L. M., Frederickson, R. C. A., Phillis, J. W., Lake, N.: 1972. Microelectrophoresis of 5-hydroxytryptamine: A clarification of its action on cerebral cortical neurones, Brain Res. 40: 552–558.
Jouvet, M.: 1969a. Neurophysiological and biochemical mechanisms of sleep, in: Sleep: Physiology and Pathology ( A. Kales, ed.), Saunders, Philadelphia.
Jouvet, M.: 19696. Biogenic amines and the states of sleep, Science 163: 32–41.
Jouvet, M.: 1972. The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle, Ergeh. Physiol. 64: 166–307.
Kales, J., Kales, A., Bixler, E., Slye, E. S.: 1971. Effects of placebo and flurazepam on sleep patterns in insomniac subjects, Clin. Pharmacol. Ther. 12: 691–697.
Kanai, T., Szerb, J. C.: 1965. Mesencephalic reticular activating system and cortical acetylcholine output, Nature 205: 80–82.
Key, B. J., Marley, E. D.: 1962. The effect of the sympathomimetic amines on the behaviour and electrocortical activity of the chicken, Electroenceph. Clin. Neurophysiol. 14: 90–105.
Killam, K. F.: 1957. Pharmacological influences upon evoked electrical activity in the brain, in: Psychotropic Drugs ( S. Garattini, V. Ghetti, eds), pp. 244–251, Elsevier, Amsterdam.
König, J. F. R., Klippel, R. A.: 1963. The Rat Brain: A Stereotaxic Atlas of the Forebrain and Lower Parts of the Brain Stem, pp. 1–162, Williams and Wilkins, Baltimore.
Kooi, K. A., Bagchi, B. K.: 1964. Observations on early components of the visual evoked response and occipital rhythms, Electroenceph. Clin. Neurophysiol. 17: 638–643.
Krnjevic, K.: 1974. Chemical nature of synaptic transmission in vertebrates, Physiol. Rev. 54: 418–540.
Krnjevic, K., Phillis, J. W.: 1963a. Actions of certain amines on cerebral cortical neurones, Brit. J. Pharmacol. Chemother. 20: 471–490.
Krnjevic, K., Phillis, J. W.: 1963b. Pharmacological properties of acetylcholine-sensitive cells in the cerebral cortex, J. Physiol. 166: 328–350.
Kuffler, S. W.: 1967. Neuroglial cells: Physiological properties and a potassium mediated effect of neuronal activity on the glial membrane potential, Proc. Roy. Soc. Lond. Ser. B 168: 1–21.
Leimdorfer, A., Metzner, W. R. T.: 1949. Analgesia and anaesthesia induced by epinephrine, Am. J. Physiol. 157: 116–121.
Levy, R. A., Anderson, E. G.: 1973. Bicuculline and picrotoxin blockade of positive dorsal root potentials, Nature 241: 156–157.
Lewis, S. A.: 1970. Comparative effects of some amphetamine derivatives on human sleep, in: Amphetamines and Related Compounds ( E. Costa, S. Garattini, eds.), Raven Press, New York.
Lidbrink, P.: 1974. The effect of lesions of ascending noradrenaline pathways on sleep and waking in the rat, Brain Res. 74: 19–40.
Longo, V. G.: 1962. Electroencephalographic Atlas for Pharmacological Research, Elsevier, Amsterdam.
Longo, V. G.: 1966. Behavioral and electroencephalographic effects of atropine and related compounds, Pharmacol Rev. 18: 965–996.
Longo, V. G., Florio, V.: 1970. Effects of neuroleptic drugs on the cerebral electrical activity of laboratory animals: Presentation of a model design for neuropharmacological experiments, Acta Neuropsychiat. Belg.
Lucas, E. A., Powell, E. W., Murphree, O. D.: 1974. Hippocampal theta in nervous pointer dogs, Physiol. Behav. 12: 609–613.
Marley, E., Stephenson, J. D.: 1972. Central actions of catecholamines, in: Handbook of Experimental Pharmacology, Vol. 33: Catecholamines ( H. Blaschko, E. Muscholl eds.), pp. 463–537, Springer, Heidelberg.
Matousek, M.: 1973. Frequency and correlation analysis in Handbook of Electroencephalography and Clinical Neurophysiology, Vol. 5A, editor A. Remand, pp. 1–108, Elsevier, Amsterdam.
Meldrum, B. S.: 1966. Drug-induced changes in EEG activity and the form of cortical potentials evoked by somatosensory stimulation, Electroenceph. Clin. Neurophysiol. 21: 309.
Meldrum, B. S.: 1975. Epilepsy and GABA-mediated inhibition, Int. Rev. Neurobiol. 17: 1–36.
Meldrum, B. S., Horton, R. W.: 1971. Convulsive effects of 4-deoxypyridoxine and of bicuculline in photosensitive baboons (Papio papio) and in rhesus monkeys (Macaca mulatto), Brain Res. 35: 419–436.
Meldrum, B. S., Horton, R. W.: 1973. Physiology of status epilepticus in primates, Arch. Neurol. 28: 1–9.
Meldrum, B. S., Horton, R. W.: 1974. Neuronal inhibition mediated by GABA and patterns of convulsions in photosensitive baboons with epilepsy (Papio papio), in: The Natural History and Management of Epilepsy ( P. Harris, C. Maudsley, eds.), Churchill Livingstone, London.
Meldrum, B. S., Naquet, R.: 1971. Effects of psilocybin, dimethyltryptamine, mescaline and various lysergic acid derivatives on the EEG and on photically-induced epilepsy in the baboon (Papio papio), Electroenceph. Clin. Neurophysiol. 31: 563–572.
Meldrum, B. S., Naquet, R., Balzano, E.: 1970a. Effects of atropine and eserine on the electroencephalogram, on behaviour and on light-induced epilepsy in the adolescent baboon (Papio papio), Electroenceph. Clin. Neurophysiol. 28: 449–458.
Meldrum, B. S., Balzano, E., Gadea, M., Naquet, R.: 19706, Photic and drug-induced epilepsy in the baboon (Papio papio): The effects of isoniazid, thiosemicarbazide, pyridoxine and amino-oxyacetic acid, Electroenceph. Clin. Neurophysiol. 29: 333–347.
Meldrum, B. S., Fariello, R. G., Puil, E. A., Derouaux, M., Naquet, R.: 1974. A9-Tetrahydrocannabinol and epilepsy in the photosensitive baboon, (Papio papio), Epilepsia. 15: 255–264.
Mitchell, J. F.: 1963. The spontaneous and evoked release of acetylcholine from the cerebral cortex, J. Physiol. 165: 98–116.
Monnier, M., Gangloff, H.: 1961. Atlas for Stereotaxic Brain Research on the Conscious Rabbit, Elsevier, Amsterdam.
Moruzzi, G., Magoun, H. W.: 1949. Brain stem reticular formation and activation of the EEG, Electroenceph. Clin. Neurophys. 1: 455–473.
Moss, R. L., Urban, I., Cross, B. A.: 1972. Microelectrophoresis of cholinergic and aminergic drugs on paraventricular neurons, Am. J. Physiol. 223: 310–318.
Murphree, H., Goldstein, L., Pfeiffer, C., Schramm, L., Jenney, E.: 1964. Computer analysis of drug effects on the EEG of normal and psychotic subjects, Int. J. Neuropharmacol. 3: 97–104.
Ogunremi, O. O., Adamson, L., Brezinova, V., Hunter, W. M., Maclean, A. W., Oswald, I., Percy-Robb, I. W.: 1973. Two anti-anxiety drugs: A psychoneuroendocrine study, Brit. Med. J. 2: 202–205.
Pampiglione, G.: 1963. Development of Cerebral Function in the Dog, pp. 1–68, Butterworths, London.
Parmeggiani, P. L.: 1967. On the functional significance of the hippocampal Rhythm, in: Progress in Brain Research: Structure and Function of the Limbic System. ( T. Tokizane, ed.), pp. 413–441, Elsevier, Amsterdam.
Pellegrino, I., Cuchman, I.: 1967. A Stereotaxic Atlas of the Rat Brain, Century Psychology Series, Appleton-Century-Crofts, New York.
Phillips, C. G.: 1956. Intracellular records from Betz cells in the cat, Quart. J. Exp. Physiol. 41: 58–69.
Ray, C. D., Bickford, R. G., Clark, L. C., Johnston, R. E., Richards, T. M., Rogers, D., Russert, W. E.: 1965a. A new multicontact, multipurpose, brain depth probe: Details of construction, Mayo Clin. Proc. 40: 771–780.
Ray, C. D., Bickford, R. G., Clark, L. C., Russert, W. E.: 1965b. A new multicontact, multipurpose, brain depth probe: First experimental results, Mayo Clin. Proc. 40: 781–790.
Rechtshaffen, A., Kales, A.: (eds.), 1968. A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects, U.S. Public Health Service Publication No. 204, Government Printing Office, Washington, D.C.
Regan, D.: 1972. Evoked Potentials in Psychology, Sensory Physiology and Clinical Medicine, pp. 1–328, Chapman and Hall, London.
Riche, D., Christolomme, A., Bert, I., Naquet, R.: 1968. Atlas Stéréotaxique du Cerveau du Babouin, Papio papio, Editions du Centre National de la Recherche Scientifique, Paris.
Rinaldi, F., Himwich, H. E.: 1955. Alerting responses and actions of atropine and cholinergic drugs, AMA Arch. Neurol. Psychiat. 73: 387–395.
Roberts, M. H. T., Straughan, D. W.: 1967. Excitation and depression of cortical neurons by 5-hydroxytryptamine, J. Physiol. 193: 269–294.
Rodin, E., Onuma, T., Wasson, S., Porzak, J., Rodin, M.: 1971. Neurophysiologies mechanisms involved in grand mal seizures induced by metrazol and megimide, Electroenceph. Clin. Neurophysiol. 30: 62–72.
Rossi, G. F., Zanchetti, A.: 1957. The brain stem reticular formation: Anatomy and physiology, Arch. Ital. Biol. 95: 203–435.
Rothballer, A. B.: 1956. Studies on the adrenaline-sensitive component of the reticular activating system, Electroenceph. Clin. Neurophysiol. 8: 603–621.
Satinsky, D.: 1967. Pharmacological responsiveness of lateral geniculate nucleus neurons, Int. J. Neuropharmacol. 6: 387–397.
Sato, K., Kitajima, H., Mimura, K., Hirota, N., Tagawa, Y., Ochi, N.: 1971. Cerebral visual evoked potentials in relation to EEG, Electroenceph. Clin. Neurophysiol. 30: 123–138.
Schmidt, R. F.: 1971. Presynaptic inhibition in the vertebrate central nervous system. Ergeh. Physiol. 63: 20–101.
Sheer, D. E.: (ed.), 1961. Electrical Stimulation of the Brain, University of Texas Press, Austin.
Sherwood, N. M., Timiras, P. S.: 1970. A Stereotaxic Atlas of the Developing Rat Brain, University of California Press, Berkeley.
Shipton, H. W.: 1961. Engineering considerations in the design of waveform analyser of the Walter type, Electroenceph, Clin. Neurophysiol. Suppl. 20: 25–30.
Shute, C. C. D., Lewis, P. R.: 1967. The ascending cholinergic reticular system: Neocortical, olfactory and subcortical projections, Brain 90: 497–520.
Snider, R. S., Lee, J. C.: 1961. A Stereotaxic Atlas of the Monkey Brain (Macaca mulatta), University of Chicago Press, Chicago.
Snider, R. S., Niemer, W.T.: 1961. A Stereotaxic Atlas of the Cat Brain, University of Chicago Press, Chicago.
Spooner, C. E., Winters, W. D.: 1967. The influence of centrally active amine induced blood pressure changes on the electroencephalogram and behaviour, Int. J. Neuropharmacol. 6: 109–118.
Storm van L.W., Bickford, R., Brazier, M., Cobb, W. A., Dondey, M., Gastaut, H., Gloor, P., Henry, C. E., Hess, R., Knott, J. R., Kugler, J., Lairy, G. C., Loeb, C., Magnus, O., Oller-Daurella, L., Petsche, H., Schwab, R., Walter, W. G., Widen, L.: 1966. Proposal for an EEG terminology, Electroenceph. Clin. Neurophysiol. 20: 306–310.
Thierry, A. M., Stinus, L., Blanc, G., Glowinski, J.: 1973. Some evidence for the existence of dopaminergic neurons in the rat cortex, Brain Res. 50: 230–234.
Towe, A. L.: 1966. On the nature of the primary evoked response, Exp. Neurol. 15: 113–139.
Verhaart, W. J. L.: 1964. A Stereotaxic Atlas of the Brain Stem of the Cat,-Van Gorcum, Assen.
Votava, Z., Dyntarova, H.: 1970. In: The Neuroleptics (D. P. Bobon, P. A. J. Janssen, J. Bobon, eds.), pp. 102–103, Karger, Basel.
Vuillon-Cacciuttolo, G., Meldrum, B. S., Balzamo, E.: 1973. Electrocorticogram and afferent visual transmission in the epileptic baboon (Papio papio), Epilepsia 14: 213–221.
Wada, J. A., Balzamo, E., Meldrum, B. S., Naquet, R.: 1972. Behavioural and electrographic effects of L-5-hydroxytryptophan and D,L-parachlorophenylalanine on epileptic Senegalese baboon (Papio papio), Electroenceph. Clin. Neurophysiol. 33: 520–526.
Walter, W. G., Cooper, R., Aldridge, V. J., Mccallum, W. C., Winter, A. L.: 1964. Contingent negative variation: An electric sign of sensorimotor association and expectancy in the human brain, Nature 203: 380–384.
Weil-Malherbe, H.: 1960. The passage of catecholamines through the blood-brain barrier, in: Adrenergic Mechanisms ( J. R. Vane, G. E. W. Wolstenholme, M. O’Connor, eds.), pp. 421–423, Churchill, London.
Wikler, A.: 1952. Pharmacologic dissociation of behaviour and EEG sleep patterns: in dogs: Morphine, n-allylmorphine, and atropine, Proc. Soc. Exp. Biol. Med. 79: 261–265.
White, R. P., Rudolph, A. S.: 1967. Neurophysiological comparison of subcortical actions of anticholinergic compounds, in: Progress in Brain Research, Vol. 28, ( P. B. Bradley, M. Fink, eds.), Elsevier, Amsterdam, pp. 14–26.
Wünscher, W., Schober, W., Werner, L.: 1965. Architektonischer Atlas von Hirnstamm der Ratte, pp. 1–61, Hirzel, Leipzig.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Plenum Press, New York
About this chapter
Cite this chapter
Meldrum, B. (1975). Electrical Recording of Brain Activity: The EEG and its Value in Assessing Drug Effects. In: Iversen, L.L., Iversen, S.D., Snyder, S.H. (eds) Principles of Receptor Research. Handbook of Psychopharmacology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3168-1_3
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3168-1_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3170-4
Online ISBN: 978-1-4684-3168-1
eBook Packages: Springer Book Archive