Summary
Studies using an indirect radioimmunofixation assay, have revealed the presence of a serum factor (or factors) in schizophrenic patients with the capacity to bind to human brain tissue, as well as to other human and mouse tissues.
The tissue binding property is detected in the serum of 50%–60% of schizophrenic patients, and in the serum of about 10% or less of blood-bank donors.
The serum factor precipitates with 33% saturated ammonium sulfate but does not seem to be IgG.
It is unknown whether or not this tissue-binding property of schizophrenic serum is an immunological reaction.
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© 1977 Plenum Press, New York
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Witz, I.P., Anavi, R., Weisenbeck, H. (1977). A Tissue-Binding Factor in the Serum of Schizophrenic Patients. In: Gershon, E.S., Belmaker, R.H., Kety, S.S., Rosenbaum, M. (eds) The Impact of Biology on Modern Psychiatry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0778-5_8
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DOI: https://doi.org/10.1007/978-1-4684-0778-5_8
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