Abstract
One of the major contributions that the research scientist can make to psychiatry is to elucidate the mechanism of existing psychotropic drugs and to design suitable tests for the discovery of new ones.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Randrup, A. and Munkvad, I.: Stereotyped activities produced by amphetamine in several animal species and man. Psychopharmacologia (Berl.) II 300–310, 1967.
Matussek, N. and Linsmayer, M.: The effect of lithium and amphetamine on desmethylimipramine-Ro 4-1284 induced motor hyperactivity. Life Sciences 7, 371–375, 1968.
GRAHAME-Smith, D.G.: Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by 1-tryptophan or 5-methoxy-N, N dlmethyltryptamine in rats treated with a mono-amine oxidase inhibitor. Br. J. Pharmac. 43, 856–864, 1972.
Garattini, S.: Importance of a knowledge of drug metabolism for the assessment of drug interactions. In: Importance of Fundamental Principles in Drug Evaluation. Eds. Tedeschi, D.H. and Tedeschi, R.E., 121–139,Raven Press, New York.
Sulser, F. and Sanders-Bush, E.: Biochemical and metabolic considerations concerning the mechanism of action of amphetamine and related compounds. In: Psychotomimetic Drugs, Ed. Efron, D.H.,Raven Press, New York, 83–94 1970.
Valzelli, L.: Drugs and aggressiveness. In: Advances in Pharmacology. Eds. Garattini, S. and Shore, P.A. Vol. 5, 79–108, 1967, Academic Press, New York.
Weinstock, M. and Speiser, Z.: The effect of dl-propranolol, d-propranolol and practolol on the hyperactivity induced in rats by prolonged isolation. Psychopharmacologia, (Berl.) 30, 241–250, 1973.
Merlis, J.K.: The effect of changes in calcium content of the cerebrospinal fluid on spinal reflex activity in the dog. Amer. J. Physiol. 131, 67–72, 1940.
Barchas, J., Erdelyi, E., and Angwin, P.: Simultaneous determination of indole-and catecholamines in tissues using a weak cation exchange resin. Analyt. Biochem. 50, 1–17, 1972.
Schildkraut, J.J.: The catecholamine hypothesis of affective disorders: a review of supporting evidence. Amer. J. Psychiat. 122, 509–522, 1965.
M.R.C. Brain Metabolism unit: Modified amine hypothesis for the etiology of affective illness. Lancet II 573–577, 1972.
Sulser, F. and Sanders-Bush E.: Effect of drugs on amines in the C.N.S. Ann. Rev. Pharmacol. 11, 209–230, 1971.
Sorenson, C.A. and Ellison, G.D.: Nonlinear changes in activity and emotional reactivity scores following central noradrenergic lesions in rats. Psychopharmacologia (Berl.) 32, 313–325, 1973.
Valzelli, L: The “isolation syndrome” in mice. Psychopharmacologia 31, 305–320, 1973.
Sofia, R.D.: Effects of centrally active drugs on four models of experimentally-induced aggression in rodents. Life Sci. 8 Part 1. 705–716, 1969.
Anden, N.E. and Strömbom, U.: Adrenergic receptor blocking agents. Effects on central noradrenaline and dopamine receptors and on motor activity. Psychopharmacologia (Berl.) 38, 91–103, 1974.
Palmer, G.C., Sulser, F. and Robinson, G.A.: Effects of neurohumoral and adrenergic agents on cyclic AMP levels in various areas of rat brain in vitro. Neuropharmacol. 12, 327–337, 1973.
Anden, N-E., Strömbom, U. and Svensson, T.H.: Dopamine and noradrenaline receptor stimulation: reversal of reserpine induced suppression of motor activity. Psychopharma-cologia 29, 289–298, 1973.
Yorkston, N.J., Malik, M.K.U., Harvard, C.W.H., Zaki, S.A. and Morrison, R.C.: Propranolol in control of schizophrenic symptoms. Brit. Med. J. 4, 633–635, 1974.
Lader, M.H. and Tyrer: Central and peripheral effects of propranolol and Sotalol in normal human subjects. Br. J. Pharmac. 45, 577–560, 1972.
Eliash, S. and Weinstock, M.: Role of adrenergic neurone blockade in hypotensive action of propranolol. Br. J. Pharmac. 43, 287–294, 1971.
Mylecharane, E.J. and Raper, C: Further studies on the adrenergic neuron blocking activity of some ß-adrenoceptor antagonists and guanethidine. J. Pharmacol. 25, 213–218, 1973.
Weinstock, M. Unpublished observations.
Dunlop, D. and Shanks, R.G.: Selective blockade of adreno-ceptive ß-receptors in the heart. Br. J. Pharmac. 32, 201–212, 1968.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Plenum Press, New York
About this chapter
Cite this chapter
Weinstock, M., Speiser, Z., Ashkenazi, R. (1977). Biochemical and Pharmacological Studies on an Animal Model of Hyperactivity States. In: Gershon, E.S., Belmaker, R.H., Kety, S.S., Rosenbaum, M. (eds) The Impact of Biology on Modern Psychiatry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0778-5_11
Download citation
DOI: https://doi.org/10.1007/978-1-4684-0778-5_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-0780-8
Online ISBN: 978-1-4684-0778-5
eBook Packages: Springer Book Archive