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Hypothermic Effects of Antipsychotic Phenothiazines

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The Impact of Biology on Modern Psychiatry

Abstract

The thermal effects of d-amphetamine in rats depend upon the ambient temperature at which the animals are maintained. A dose of 5–15 mg/kg, i.p. causes marked hypothermia among rats kept at 4°C hut results in hyperthermia for rats kept at 20–37°C (Yehuda and Wurtman, 1972a). The drug also interferes with normal behavioral thermoregulation. When d-amphetamine-treated rats are placed in a temperature-gradient apparatus they tend to locate themselves far away from a heat source when the ambient temperature is 4°C, and to locate themselves near a heat source when the ambient temperature was 30°C (Yehuda and Wurtman, 1974a).

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Author information

Authors and Affiliations

  1. Department of Psychology, Bar-Ilan University, Tel-Aviv, Israel

    Shlomo Yehuda

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  1. Shlomo Yehuda
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Editors and Affiliations

  1. National Institute of Mental Health, Bethesda, Maryland, USA

    Elliot S. Gershon M.D.

  2. Jerusalem Mental Health Center Ezrath Nashim, Jerusalem, Israel

    Robert H. Belmaker M. D.  & Milton Rosenbaum M. D.  & 

  3. Harvard Medical School, Boston, Massachusetts, USA

    Seymour S. Kety M. D.

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© 1977 Plenum Press, New York

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Yehuda, S. (1977). Hypothermic Effects of Antipsychotic Phenothiazines. In: Gershon, E.S., Belmaker, R.H., Kety, S.S., Rosenbaum, M. (eds) The Impact of Biology on Modern Psychiatry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0778-5_10

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  • DOI: https://doi.org/10.1007/978-1-4684-0778-5_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-0780-8

  • Online ISBN: 978-1-4684-0778-5

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