Skip to main content

Meiotic Abnormalities

  • Chapter
Human Chromosomes

Part of the book series: Springer Study Edition ((SSE))

  • 177 Accesses

Abstract

The main events of meiosis are collected in Table 19.1 (Chapters 17 and 18). Since meiosis is a much more complicated series of events than mitosis, it is also more apt to go wrong at some point (Chandley, 1988). The main results of meiotic abnormalities are infertility or partial sterility, the latter often being combined with an increased frequency of chromosomal abnormalities in abortuses or liveborn offspring.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Awa AA, Honda T, Neriishi S, et al. (1987) Cytogenetic study of the offspring of atomic bomb survivors, Hiroshima and Nagasaki. In: Obe G, Basler A (eds) Cytogenetics. Springer, Berlin/Heidelberg, pp 166–183

    Chapter  Google Scholar 

  • Bennett MD, Toledo LA, Stern H (1979) The effect of colchicine on meiosis in Lilium speciosum cv. “Rosemede”. Chromosoma 72:175–189

    Article  CAS  Google Scholar 

  • Carr DH (1971) Chromosomes and abortion. In: Harris H, Hirschhorn K (eds) Advances in human genetics. Plenum, New York

    Google Scholar 

  • Chandley AC (1982) Normal and abnormal meiosis in man and other mammals. In: Crosignani PG, Rubin BL (eds) Genetic control of gamete production and function. Academic, London, pp 229–237

    Google Scholar 

  • Chandley AC (1988) Meiosis in man. Trends Genet 4:79–84

    Article  PubMed  CAS  Google Scholar 

  • Coerdt W, Rehder H, Gausmann I, et al. (1985) Quantitative histology of human fetal testes in chromosomal disease. Pediatr Pathol 3:245–259

    Article  PubMed  CAS  Google Scholar 

  • Darlington CD (1939) Misdivision and the genetics of the centromere. J Genet 37:341–364

    Article  Google Scholar 

  • Deng H-X, Abe K, Kondo I, et al. (1991) Parental origin and mechanism of formation of polysomy X: an XXXXX case and four XXXXY cases determined with RFLPs. Hum Genet 86:541–544

    Article  PubMed  CAS  Google Scholar 

  • FitzPatrick DR, Boyd E (1989) Recurrences of trisomy 18 and trisomy 13 after trisomy 21. Hum Genet 82:301

    Article  PubMed  CAS  Google Scholar 

  • Gagnon J, Katyk-Longtin N, de Groot JA, et al. (1961) Double trisomie auto- somique a 48 chromosomes (21 + 18). L’Union Med Canada 90:1–7

    Google Scholar 

  • Hassold TJ, Jacobs PA (1984) Trisomy in man. Annu Rev Genet 18:69–97

    Article  PubMed  CAS  Google Scholar 

  • Hassold TJ, Jacobs P, Kline J, et al. (1980) Effect of maternal age on autosomal trisomies. Ann Hum Genet 44:29–36

    Article  PubMed  CAS  Google Scholar 

  • Hecht F, Bryant JS, Gruber D, et al. (1964) The nonrandomness of chromosomal abnormalities. N Eng J Med 271:1081–1086

    Article  CAS  Google Scholar 

  • Henderson SA, Edwards RG (1968) Chiasma frequency and maternal age in mammals. Nature 218:22–28

    Article  PubMed  CAS  Google Scholar 

  • Huang T H-M, Greenberg F, Ledbetter DH (1991) Determination of the origin of nondisjunction in a 49,XXXXY male using hypervariable dinucleotide repeat sequences. Hum Genet 86:619–620

    PubMed  CAS  Google Scholar 

  • Jacobs PA, Angell RR, Buchanan IM, et al. (1978) The origin of human triploids. Ann Hum Genet 42:49–57

    Article  PubMed  CAS  Google Scholar 

  • Jacobs PA, Hassold TJ, Whittington E, et al., (1988) Klinefelter’s syndrome: an analysis of the origin of the additional sex chromosome using molecular probes. Ann Hum Genet 52:93–109

    Article  PubMed  CAS  Google Scholar 

  • Juberg RC, Mowrey PN (1983) Origin of nondisjunction in trisomy 21 syndrome: all studies compiled, parental age analysis, and international comparisons. Am J Med Genet 16:111–116

    Article  PubMed  CAS  Google Scholar 

  • Kajii T, Niikawa N (1977) Origin of triploidy and tetraploidy in man: 11 cases with chromosome markers. Cytogenet Cell Genet 18:109–125

    Article  PubMed  CAS  Google Scholar 

  • Karp LE, Smith WD (1975) Experimental production of aneuploidy in mouse oocytes. Gynecol Invest 6:337–341

    Article  PubMed  CAS  Google Scholar 

  • Koulischer L, Schoysman R, Gillerot Y, et al. (1982) Meiotic chromosome studies in human male infertility. In: Crosignani PG, Rubin BL (eds) Genetic control of gamete production and function. Academic, London, pp 239–260

    Google Scholar 

  • Laurie DA, Hultén MA (1985) Further studies on bivalent chiasma frequency in human males with normal karyotypes. Ann Hum Genet 49:189–201

    Article  PubMed  CAS  Google Scholar 

  • Levan A (1939) The effect of colchicine on meiosis in Allium. Hereditas 25:9–26

    Article  Google Scholar 

  • Luthardt FW, Palmer CG, Yu P-L (1973) Chiasma and univalent frequencies in aging female mice. Cytogenet Cell Genet 12:68–79

    Article  PubMed  CAS  Google Scholar 

  • Martin RH (1988a) Human sperm karyotyping: a tool for the study of aneuploidy. In: Vig BK, Sandberg AA (eds) Aneuploidy, Part B: induction and test systems. Liss, New York, pp 297–316

    Google Scholar 

  • Martin RH (1988b) Meiotic segregation of human sperm chromosomes in translocation heterozygotes: report of a t(9;10) (q34;qll) and a review of the literature. Cytogenet Cell Genet 47:48–51

    Article  PubMed  CAS  Google Scholar 

  • Martin RH, Rademaker AW, Hildebrand K, et al. (1987) Variation in the frequency and type of sperm chromosomal abnormalities among normal men. Hum Genet 77:108–114

    Article  PubMed  CAS  Google Scholar 

  • Martin RH, Barclay L, Hildebrand, et al. (1990) Cytogenetic analysis of 400 sperm from three translocation heterozygotes. Hum Genet 86:33–39

    Article  PubMed  CAS  Google Scholar 

  • Mattei JF, Mattei MG, Aymé S, et al. (1979) Origin of the extra chromosome in trisomy 21. Hum Genet 46:107–110

    Article  PubMed  CAS  Google Scholar 

  • McDermott A (1971) Human male meiosis. Can J Genet Cytol 13:536–549

    PubMed  CAS  Google Scholar 

  • Mikkelsen M (1971) Down’s syndrome. Current stage of cytogenetic research. Humangenetik 12:1–28

    Article  PubMed  CAS  Google Scholar 

  • Pacchierotti F (1988) Chemically induced aneuploidy in germ cells of mouse. In: Vig BK, Sandberg AA (eds) Aneuploidy, Part B: induction and test systems. Liss, New York, pp 123–139

    Google Scholar 

  • Patau K (1963) The origin of chromosomal abnormalities. Pathol Biol 11:1163–1170

    PubMed  CAS  Google Scholar 

  • Rapp M, Therman E, Denniston C (1977) Nonpairing of the X and Y chromosomes in the spermatocytes of BDF1 mice. Cytogenet Cell Genet 19:85–93

    Article  PubMed  CAS  Google Scholar 

  • Rivera H, Cantú JM (1986) Centric fission consequences in man. Ann Génét 29:223–225

    PubMed  CAS  Google Scholar 

  • Rudak E, Jacobs PA, Yanagimachi R (1978) Direct analysis of the chromosome constitution of human spermatozoa. Nature 274:911–913

    Article  PubMed  CAS  Google Scholar 

  • Searle AG (1982) The genetics of sterility in the mouse. In: Crosignani PG, Rubin BL (eds) Genetic control of gamete production and function. Academic, London, pp 93–114

    Google Scholar 

  • Sears ER (1952) Misdivision of univalents in common wheat. Chromosoma 4: 535–550

    Article  PubMed  CAS  Google Scholar 

  • Shepard J, Boothroyd ER, Stern H (1974) The effect of colchicine on synapsis and chiasma formation in microsporocytes of Lilium. Chromosoma 44:423–437

    Article  CAS  Google Scholar 

  • Solari AJ (1974) The behavior of the XY pair in mammals. Int Rev Cytol 38:273–317

    Article  PubMed  CAS  Google Scholar 

  • Speed RM (1988) The possible role of meiotic pairing anomalies in the atresia of human fetal oocytes. Hum Genet 78:260–266

    Article  PubMed  CAS  Google Scholar 

  • Speed RM, Chandley AC (1990) Prophase of meiosis in human spermatocytes analysed by EM microspreading in infertile men and their controls and comparisons with human oocytes. Hum Genet 84:547–554

    Article  PubMed  CAS  Google Scholar 

  • Stene J, Fischer G, Stene E (1977) Paternal age effect in Down’s syndrome. Ann Hum Genet 40:299–306

    Article  PubMed  CAS  Google Scholar 

  • Stene J, Stene E, Stengel-Rutkowski S, et al. (1981) Paternal age and Down’s syndrome. Data from prenatal diagnoses (DFG). Hum Genet 59:119–124

    Article  PubMed  CAS  Google Scholar 

  • Tease C (1988) Radiation-induced aneuploidy in germ cells of female mammals. In: Vig BK, Sandberg AA (eds) Aneuploidy, Part B: Induction and test systems. Liss, New York, pp 141–157

    Google Scholar 

  • Therman E, Patau K (1974) Abnormal X chromosomes in man: Origin, behavior and effects. Humangenetik 25:1–16

    PubMed  CAS  Google Scholar 

  • Therman E, Sarto GE (1983) Inactivation center on the human X chromosome. In: Sandberg AA (ed) Cytogenetics of the mammalian X chromosome, Part A. Basic mechanisms of X chromosome behavior. Liss, New York, pp 315–325

    Google Scholar 

  • Therman E, Patau K, Smith DW, et al. (1961) The D trisomy syndrome and XO gonadal dysgenesis in two sisters. Am J Hum Genet 13:193–204

    PubMed  CAS  Google Scholar 

  • Therman E, Patau K, DeMars RI, et al. (1963) Iso/telo-D1 mosaicism in a child with an incomplete trisomy syndrome. Portugal Acta Biol 7:211–224

    Google Scholar 

  • Therman E, Sarto GE, DeMars RI (1981) The origin of telocentric chromosomes in man: A girl with tel(Xq). Hum Genet 57:104–107

    Article  PubMed  CAS  Google Scholar 

  • Tuck CM, Bennett JW, Varela M (1984) Down’s syndrome and familial aneu- ploidy. In: Berg, JM (ed) Perspectives and progress in mental retardation II. University Park Press, Baltimore, pp 167–180

    Google Scholar 

  • Uchida IA (1977) Maternal radiation and trisomy 21. In: Hook EB, Porter IH (eds) Population cytogenetics. Academic, New York, pp 285–299

    Google Scholar 

  • Uchida IA, Freeman VCP (1985) Triploidy and chromosomes. Am J Obstet Gynecol 151:65–69

    PubMed  CAS  Google Scholar 

  • Villaverde MM, DaSilva JA (1975) Turner-Mongolism polysyndrome. Review of the first eight known cases. J Am Med Assoc 234:844–847

    Article  CAS  Google Scholar 

  • Wagenbichler P, Killian W, Rett A, et al. (1976) Origin of the extra chromosome no. 21 in Down’s syndrome. Hum Genet 32:13–16

    Article  PubMed  CAS  Google Scholar 

  • Webb GC, Krumins EJ, Leversha MA, et al. (1984) 49, XXYY, +18 in a liveborn male. J Med Genet 21:232

    Article  PubMed  CAS  Google Scholar 

  • Zuffardi O, Tiepolo L (1982) Frequencies and types of chromosome abnormalities associated with human male infertility. In: Crosignani PG, Rubin BL (eds) Genetic control of gamete production and function. Academic, London, pp 261–273

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag New York, Inc.

About this chapter

Cite this chapter

Therman, E., Susman, M. (1993). Meiotic Abnormalities. In: Human Chromosomes. Springer Study Edition. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-0529-3_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-0529-3_19

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-97871-0

  • Online ISBN: 978-1-4684-0529-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics