Abstract
The chromosomes of differentiated cells have been much less studied than those of meristematic or germline cells, probably because such cells do not usually divide spontaneously. However, in many cases they can be induced to undergo mitosis. Plant cells renew their mitotic activity around a wound, or after application of plant growth substances (Therman, 1951; D’Amato, 1952; Tschermak-Woess, 1956). Similarly, a portion of the mouse liver can be removed to stimulate tissue regeneration. Mouse liver cells can also be induced to divide by injecting the animal with carbon tetrachloride (CC14). However, as a rule, highly polyploid cells cannot be induced to undergo mitosis, although sometimes in cancer they do so spontaneously (Figs. 30.2d and 30.4d).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Barlow PW (1978) Endopolyploidy: towards an understanding of its biological significance. Acta Biotheor (Leiden) 27:1–18
Beerman W (1962) Riesenchromosomen. In: Protoplasmatologia, Handbuch der Protoplasmaforschung, Vol VI, D. Springer, Vienna
D’Amato F (1952) Polyploidy in the differentiation and function of tissues and cells in plants. Caryologia 4:311–358
D’Amato F (1977) Nuclear cytology in relation to development. University Press, Cambridge, England
D’Amato F (1984) Role of polyploidy in reproductive organs and tissues. In: Johri BM (ed) Embryology of angiosperms. Springer, Heidelberg, pp 519–566
D’Amato F (1989) Polyploidy in cell differentiation. Caryologia 42:183–211
Geitler L (1953) Endomitose und endomitotische Polyploidisierung. In: Protoplasmatologia, Handbuch der Protoplasmaforschung, Vol VI, C. Springer, Vienna
Heitz E (1953) Über intraindividuale Polyploidie. Arch Julius Klaus-Stiftung 28: 260–271
Heitz E, Bauer H (1933) Beweise für die Chromosomennatur der Kernschleifen in den Knäuelkernen von Bibio hortulanus L. Z Zellforsch 17:67–82
John B (1988) The biology of heterochromatin. In: Verma RS (ed) Heterochromatin: molecular and structural aspects. Cambridge University, Cambridge, pp 1–147
Kuhn EM, Therman E (1988) The behavior of heterochromatin in mouse and human nuclei. Cancer Genet Cytogenet 34:143–151
Kuhn EM, Therman E, Susman B (1991) Amitosis and endocycles in early cultured mouse trophoblast. Placenta 12:251–261
Nagl W (1978) Endopolyploidy and polyteny in differentiation and evolution. Elsevier/North-Holland, Amsterdam
Nagl W (1981) Polytene chromosomes of plants. Int Rev Cytol 73:21–53
Nagl W (1982) Cell growth and nuclear DNA increase by endoreduplication and differential DNA replication. In: Nicolini C (ed) Cell growth. Plenum, New York, pp 619–651
Oksala T, Therman E (1974) Mitotic abnormalities and cancer. In: German J (ed) Chromosomes and cancer. Wiley & Sons, New York, pp 239–263
Osheim YN, Miller OL Jr (1983) Novel amplification and transcriptional activity of chorion genes in Drosophila melanogaster follicle cells. Cell 33:543–553
Painter TS (1933) A new method for the study of chromosome rearrangements and the plotting of chromosome maps. Science 78:585–586
Patau K, Srinivasachar D (1960) A microspectrophotometer for measuring the DNA-content of nuclei by the two wave length method. Cytologia 25:145–151
Sarto GE, Stubblefield PA, Lurain J, et al. (1984) Mechanisms of growth in hydatidiform moles. Am J Obstet Gynecol 148:1014–1023
Therman E (1951) The effect of indole-3-acetic acid on resting plant nuclei. I. Allium cepa. Ann Acad Sci Fenn A IV 16:1–40
Therman E, Kuhn EM (1989) Mitotic modifications and aberrations in cancer. CRC Crit Rev Oncogen 1:293–305
Therman E, Sarto GE, Stubblefield PA (1983) Endomitosis: a reappraisal. Hum Genet 63:13–18
Therman E, Sarto GE, Kuhn EM (1986) The course of endomitosis in human cells. Cancer Genet Cytogenet 19:301–310
Tschermak-Woess E (1956) Karyologische Pflanzenanatomie. Protoplasma 46: 798–834
Tschermak-Woess E (1971) Endomitose. Handb Allg Pathol 2:569–625
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag New York, Inc.
About this chapter
Cite this chapter
Therman, E., Susman, M. (1993). Chromosomal Differentiation of Cells. In: Human Chromosomes. Springer Study Edition. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-0529-3_16
Download citation
DOI: https://doi.org/10.1007/978-1-4684-0529-3_16
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-97871-0
Online ISBN: 978-1-4684-0529-3
eBook Packages: Springer Book Archive