Abstract
Platelets are activated by many different agonists, lach agonist presumably acts on a different receptor, but in no case has a receptor been defined1. Thrombin is perhaps the most potent physiological platelet agonist. In this paper, we review the current state of knowledge of the mechanism of thrombin-induced platelet activation. Results of studies of the binding of thrombin to platelets are summarized, the general characteristics of thromb in-induced platelet activation are described, the implications of these characteristics on possible mechanisms are discussed, and the possible involvement of glycoprotein V as a receptor is evaluated. Finally, special considerations for the use of thrombin as the agonist in studies of stimulus-response coupling mechanisms are discussed.
This work was supported by grant HL 16355 from the National Institutes of Health, U. S. Public Health Service
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© 1985 Plenum Press, New York
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Detwiler, T.C., McGowan, E.B. (1985). Platelet Receptors for Thrombin. In: Westwick, J., Scully, M.F., MacIntyre, D.E., Kakkar, V.V. (eds) Mechanisms of Stimulus—Response Coupling in Platelets. Advances in Experimental Medicine and Biology, vol 192. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9442-0_2
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DOI: https://doi.org/10.1007/978-1-4615-9442-0_2
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