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Regional Changes in Intramyocardial Pressure Following Myocardial Ischemia

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Current Topics in Coronary Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 39))

Abstract

Previous studies from this laboratory have demonstrated the presence of regional abnormalities in myocardial blood flow during ischemia (1). The finding of relative subendocardial ischemia following coronary artery occlusion is thought to be due to a decrease in the diastolic coronary perfusion gradient (2). This gradient depends upon the relationship between the distal coronary artery perfusion pressure and left ventricular end diastolic pressure. The present study was undertaken to determine whether delayed relaxation might also occur following myocardial ischemia and thereby further compromise the effect of diastolic coronary perfusion gradient.

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References

  1. Becker, L.C., Fortuin, N.J., Pitt, B.: Effect of ischemia and antianginal drugs on the distribution of radioactive microspheres in the canine left ventricle. Circ. Res. 28:263, 1971.

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  2. Becker, L., Pitt, B.: Regional myocardial blood flow, ischemia and antianginal drugs. Annals of Clinical Research 3:353, 1971.

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  3. Bing, O.H.L., Keefe, J.F., Wolk, M.J., Finkelstein, L.J., Levine, H.J.: Tension prolongation during recovery from myocardial hypoxia. Journal of Clinical Investigation 50:660, 1971.

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Author information

Authors and Affiliations

  1. School of Medicine, The Johns Hopkins Hospital and Johns Hopkins University, Baltimore, Maryland, 21205, USA

    David T. Kelly & Bertram Pitt

Authors
  1. David T. Kelly
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  2. Bertram Pitt
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Editor information

Editors and Affiliations

  1. Department of Pathology, University of California at San Diego, La Jolla, California, USA

    Colin M. Bloor

  2. Division of Medicine, Walter Reed Army Institute of Research, Washington, D. C., USA

    Ray A. Olsson

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© 1973 Plenum Press, New York

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Kelly, D.T., Pitt, B. (1973). Regional Changes in Intramyocardial Pressure Following Myocardial Ischemia. In: Bloor, C.M., Olsson, R.A. (eds) Current Topics in Coronary Research. Advances in Experimental Medicine and Biology, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9020-0_8

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  • DOI: https://doi.org/10.1007/978-1-4615-9020-0_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9022-4

  • Online ISBN: 978-1-4615-9020-0

  • eBook Packages: Springer Book Archive

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