Skip to main content
SpringerLink
Log in

Factors Determining the Distribution and Adequacy of Left Ventricular Myocardial Blood Flow

  • Chapter
Current Topics in Coronary Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 39))

Abstract

Left ventricular subendocardial necrosis and fibrosis occurs in patients whose coronary arteries are normal (1–3). In the absence of coronary artery obstruction, these changes are likely due to a discrepancy between cardiac oxygen demands and myocardial oxygen supply.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Friedberg, C.K., and Horn, H. Acute myocardial infarction not due to coronary artery occlusion. JAMA 112:1675, 1939.

    Article  Google Scholar 

  2. Horn, H., Field, L.E., Dack, S., and Master, A.M. Acute coronary insufficiency: Pathologic and physiologic aspects. Am. Heart J. 40:63, 1950.

    Article  PubMed  CAS  Google Scholar 

  3. Moller, J.H., Nakeb, A., and Edwards, J.E.: Infarction of the papillary muscle and mitral insufficiency associated with congenital aortic stenosis. Circulation 34:87, 1966.

    Article  PubMed  CAS  Google Scholar 

  4. Katz, L.N., and Feinberg, H. The relation of cardiac effort to myocardial oxygen consumption and coronary flow. Circ. Res. 6:656, 1958.

    Article  PubMed  CAS  Google Scholar 

  5. Winbury, M.M. Redistribution of left ventricular blood flow produced by nitroglycerin. Circ. Res. 28–I:140, 1971.

    Google Scholar 

  6. Taber, R.E., Morales, A.R., and Fine, G. Myocardial necrosis and the post-operative low cardiac output syndrome. Ann. Thorac. Surg. 4:12, 1967.

    Article  Google Scholar 

  7. Najafi, H., Henson, D., Dye, W.S., Javid, H., Hunter, J.A., Callaghan, R., Eienstein, R., and Julian, O.C. Left ventricular hemorrhagic necrosis. Ann. Thorac. Surg. 7:550, 1969.

    Article  PubMed  CAS  Google Scholar 

  8. Domenench, R. J., Hoffman, J.I.E., Noble, M.I.M., Saunders, K.B., Henson, J.R., and Subijanto, S. Total and regional coronary blood flow measured by radioactive microspheres in conscious and anesthetized dogs. Circ. Res. 25:581, 1969.

    Article  Google Scholar 

  9. Phibbs, R.H., and Dong, L. Nonuniform distribution of microspheres in blood flowing through a medium-size artery. Canad. J. Physiol. Pharmacol. 48:415, 1970.

    Article  CAS  Google Scholar 

  10. Buckberg, C.D., Fixier, D.E., Archie, J.P., and Hoffman, J.I. E. Experimental subendocardial ischemia in dogs with normal coronary arteries. Circ. Res. 30:67, 1972.

    Article  PubMed  CAS  Google Scholar 

  11. Kirk, E.S., and Honig, C.R. Experimental and theoretical analysis of myocardial tissue pressure. Am. J. Physiol. 207: 361, 1964.

    PubMed  CAS  Google Scholar 

  12. Brandi, G., and McGregor, M. Intramural pressure in the left ventricle of the dog. Cardiovasc. Res. 3:472, 1969.

    Article  PubMed  CAS  Google Scholar 

  13. Cutarelli, R., and Levy, M.N. Intraventricular pressure and the distribution of coronary blood flow. Circ. Res. 12:322, 1963.

    Article  PubMed  CAS  Google Scholar 

  14. Love, W.B. Isotope clearance and myocardial blood flow. Am. Heart J. 67:579, 1964.

    Article  PubMed  CAS  Google Scholar 

  15. Gregg, D.E., and Fisher, L.C. Blood supply to the heart. In: HANDBOOK OF PHYSIOLOGY, Sec. 2, vol. 2, Circulation, (Eds.) W.F. Hamilton and P. Dow, Williams and Wilkins Co., Baltimore, 1962, p. 1534.

    Google Scholar 

  16. Myers, W.W., and Honig, C.R. Number and distribution of capillary determinants of myocardial oxygen tension. Am. J. Physiol. 207:653, 1954.

    Google Scholar 

  17. Buckberg, C.D., Luck, J.C., and Hoffman, J.I.E. Total and regional coronary blood flow after acute arteriovenous fistula. Surg. Forum 21:171, 1970.

    PubMed  CAS  Google Scholar 

  18. Vincent, W.R., Sakamoto, J.R., and Buckberg, G.D. Mechanism of cardiac failure in experimental patent ductus arteriosus. Am. J. Cardiol. 29:295, 1972.

    Article  Google Scholar 

  19. Buckberg, G.D., and Ross, G. The effects of Isoprenaline on coronary blood flow, its distribution and myocardial performance. Cardiovasc. Res. (in press).

    Google Scholar 

  20. Buckberg, G.D., Archie, J.P., Fixier, D.E., and Hoffman, J.I.E. Experimental subendocardial ischemia during left ventricular hypertension. Surg. Forum 22:123, 1971.

    Google Scholar 

  21. Sarnoff, S.J., Braunwald, E., Welch, G.H., Jr., Case, R.B., Stainsby, W.N., and Macruz, R. Hemodynamic determinants of oxygen consumption of the heart with special reference to the tension time index. Am. J. Physiol. 192:148, 1958.

    PubMed  CAS  Google Scholar 

  22. Olsson, R.A. Changes in content of purine nucleoside in canine myocardium during coronary occlusion. Circ. Res. 26: 301, 1970.

    Article  PubMed  CAS  Google Scholar 

  23. Berne, R.M. Cardiac nucleotides in hypoxia: Possible role in regulation of coronary blood flow. Am. J. Physiol. 204:317, 1963.

    PubMed  CAS  Google Scholar 

  24. Menno, A.D. and Schenck, W.G. Dynamics of coronary arterial flow: Flow alterations resulting from certain surgical procedures and drugs of surgical importance. Surgery 50:82, 1961.

    PubMed  CAS  Google Scholar 

  25. Karp, R.B. and Roe, B.B. Effect of aortic insufficiency on phasic flow patterns in the coronary artery. Ann. Surg. 164: 959, 1966.

    Article  PubMed  CAS  Google Scholar 

  26. Delin, N.A. Systolic and diastolic coronary arterial blood flow in epxerimental valvular and supravalvular aortic stenosis. Scand. J. Thorac. Cardiovasc. Surg. 3–I:54, 1969.

    Google Scholar 

  27. Sonnenblick, E.H., Ross, J., Jr., Covell, J.W., Kaiser, G.A., and Braunwald, E. Velocity of contraction as a determinant of myocardial oxygen consumption. Am. J. Physiol. 209:191, 1965.

    Google Scholar 

  28. Lie, J.T., Holley, K.E., Kampa, W.R., and Titus, J.L.: New histochemical method for morphologic diagnosis of early stages of myocardial ischemia. Mayo Clin. Proc. 46:319, 1971.

    PubMed  CAS  Google Scholar 

  29. Buckberg, G.D., Towers, B., Paglia, D.E., Mulder, D.G., Maloney, J.V. Subendocardial ischemia after cardiopulmonary bypass. J. Thorac. Cardiovasc. Surg. 64:669, 1972.

    PubMed  CAS  Google Scholar 

  30. Griggs, D.M., Vassil, V.T., and Chin, C.C. Transmural differences in ventricular tissue substrate levels due to coronary constriction. Am. J. Physiol. 222:705, 1972.

    PubMed  CAS  Google Scholar 

  31. Hottenrott, C., Buckberg, G.D., and Maloney, J.V., Jr. The effects of ventricular fibrillation on the distribution and adequacy of coronary blood flow. Surg. Forum 23:200, 1972.

    PubMed  CAS  Google Scholar 

  32. Fallen, E.L., Elliot, E.C, and Gorlin, R.: Mechanisms of angina in aortic stenosis. Circulation 36:480, 1967.

    Article  PubMed  CAS  Google Scholar 

  33. Maron, B.J., and Sissman, N.J. The electrocardiogram in supravalvar aortic stenosis. Am. Heart J. 82:300, 1971.

    Article  PubMed  CAS  Google Scholar 

  34. Underhill, W.L., Tredway, J.B., D’Angelo, G.J., and Baay, J.E.M. Familial supravalvar aortic stenosis: Comments on the mechanisms of angina pectoris. Am. J. Cardiol. 27:560, 1971.

    Article  PubMed  CAS  Google Scholar 

  35. Roven, R.B., Crampton, R.S., and Case, R.B. Effects of compromising right ventricular function in left ventricular failure by means of interatrial and other shunts. Am. J. Cardiol. 24:209, 1969.

    Article  PubMed  CAS  Google Scholar 

  36. Buckberg, G.D., Fixier, D.E., Archie, J.P., Henney, R.P., and Hoffman, J.I.E.: Variable effects on heart rate on phasic and regional left ventricular muscle blood flow. J. Clin. Invest. (submitted).

    Google Scholar 

  37. Rona, G., Chappel, C.I., Balazas, T., and Gaudry, R. An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the rat. Arch. Pathol. 67:443, 1959.

    CAS  Google Scholar 

  38. Maroko, P.R., Kjekshus, J.K., Sobel, B.E., Watanabe, T., Covell, J.W. and Ross, J., Jr. Factors influencing infarct size following experimental coronary artery occlusions. Circulation 43:67, 1971.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Thoracic Surgery, Department of Surgery and the Division of Cardiology, Department of Medicine, UCLA Medical Center, Los Angeles, California, 90024, USA

    Gerald D. Buckberg M. D. & Albert A. Kattus Jr. M.D.

Authors
  1. Gerald D. Buckberg M. D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Albert A. Kattus Jr. M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pathology, University of California at San Diego, La Jolla, California, USA

    Colin M. Bloor

  2. Division of Medicine, Walter Reed Army Institute of Research, Washington, D. C., USA

    Ray A. Olsson

Rights and permissions

Reprints and permissions

Copyright information

© 1973 Plenum Press, New York

About this chapter

Cite this chapter

Buckberg, G.D., Kattus, A.A. (1973). Factors Determining the Distribution and Adequacy of Left Ventricular Myocardial Blood Flow. In: Bloor, C.M., Olsson, R.A. (eds) Current Topics in Coronary Research. Advances in Experimental Medicine and Biology, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9020-0_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9020-0_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9022-4

  • Online ISBN: 978-1-4615-9020-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation