Abstract
There is considerable evidence that adenosine may play an important role in the regulation of coronary vascular tone in response to myocardial oxygen demand (1). The experimental proof of this hypothesis requires a definition of: 1. the factors regulating adenosine production, 2. the processes regulating the concentration of this nucleoside in the cardiac interstitial space, i.e., the concentration to which the coronary arteries are exposed, and 3. the mechanism by which this nucleoside induces relaxation of the coronary vascular smooth muscle cell.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Bibliography
Berne, R.M., Am. J. Physiol. 204:317, 1963.
Rostgaard, J. and Behnke, O., J. Ultrastructure Res. 12:579, 1965.
Gordon, G.B., Price, H.M. and Blumberg, J.M., Lab. Invest. 16: 422, 1967.
Nakatsu, K. and Drummond, G.I., Am. J. Physiol. 223:1119, 1972.
Burgers, M., Schaper, J. and Schaper, W., J. Histochem. Cyto-chem. 19:526, 1971.
Emmelot, P., Bos, C.J., Benedetti, E.L. and Rümke, P.L., Bio-chim. Biophys. Acta 90:126, 1964.
Coleman, R. and Finean, J.B., Biochim. Biophys. Acta 125:197, 1966.
Olsson, R.A., Snow, J.A., Gentry, M.K., and Frick, G.P., Circ. Res. 31:767, 1972.
Olsson, R.A., Circ. Res. 26:301, 1970.
Baer, H.P., Drummond, G.I., and Duncan, E.L., Mol. Pharmacol. 2:67, 1966.
Edwards, M.T. and Maguire, H.H., Mol. Pharmacol. 6:641, 1970.
Sullivan, J.M. and Alpers, J.B., J. Biol. Chem. 246:3057, 1971.
Burger, R.M., Doctoral Thesis, Princeton University, 1967.
Avruch, J. and Wallach, D.F.A., Biochim. Biophys. Acta 233:334, 1971.
Bowers, G.N. and McComb, R.B., Clin. Chem. 12:70, 1966.
Lowry, O.H., Roseborough, N.J., Farr, A.L., and Randall, R.J., J. Biol. Chem. 193:265, 1965.
Kono, T. and Colowick, S.P., Arch. Biochem. Biophys. 93:520, 1961.
Tada, M., Finney, J.O., Jr.k Swartz, M.H., and Katz, A.M., J. Mol. Cell. Cardiol. 4:417, 1972.
Emmelot, P. and Bos, C.J., Biochim. Biophys. Acta 150:341, 1968.
Widnell, C.C. and Unkeless, J.C., Proc. Nat. Acad. Sci., 61: 1050, 1968.
Rethy, A., Tomasi, V., Treviscani, A. and Barnabei, O., Biochim. Biophys. Acta 290:58, 1972.
Wollenberger, A. and Krause, E.G., Am. J. Cardiol. 22:359, 1968.
Kukovetz, W.R., and Pöch, G., In: Advances in Cyclic Nucleotide Research (Greengard, P., Paoleti, R. and Robison, G.A., (Eds.), Vol. 1, p. 261, Raven Press, New York, 1972.
Sattin, A. and Rall, T.W., Mol. Pharmacol. 6:13, 1970.
Shimizu, H., Creveling, C.R. and Daly, J.W., Mol. Pharmacol. 6:184, 1970.
Wollenberger, A., Krause, E.G., and Heier, G., Biochem. Biophys. Res. Commun. 36:664, 1969.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1973 Plenum Press, New York
About this chapter
Cite this chapter
Olsson, R.A., Gentry, M.K., Townsend, R.S. (1973). Adenosine Metabolism: Properties of Dog Heart Microsomal 5′-Nucleotidase. In: Bloor, C.M., Olsson, R.A. (eds) Current Topics in Coronary Research. Advances in Experimental Medicine and Biology, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9020-0_3
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9020-0_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9022-4
Online ISBN: 978-1-4615-9020-0
eBook Packages: Springer Book Archive