Abstract
There are many reports in the literature of the action of glyceryl trinitrate (GTN) on the coronary circulation. The effects have been studied on both the natural and the collateral circulation, using such techniques as direct flow measurement (1), radioisotope clearance (2), retrograde flow (3), peripheral pressure (4), pressure gradient (5), etc.; and there are as many explanations of the mode of action of the drug. This is a preliminary reports on the effects of GTN on the pre-existing coronary collateral vessels in the open chest dog. A beta ray detector affixed to the epicardial surface was used to obtain washout curves of 85Kr.
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References
Khouri, E.M., Gregg, D.E., and Lowensohn, H.S.: Flow in the major branches of the left coronary artery during experimental coronary insufficiency in the unanesthetized dog. Circ. Res. 23:99, 1968.
Rees, R. J., Redding, V. J., Ashfield, R., Gibson, D., and Gavey, C.J.: Myocardial blood flow measurements with 133Xe Effect of glyceryl trinitrate in dogs. Brit. Heart J. 28:374, 1966.
Leighinger, D.S., Rueger, R., and Beck, C.S.: Effect of glyceryl trinitrate (nitroglycerin) on arterial blood supply to ischemic myocardium. Am. J. Cardiol. 3:638, 1959.
Pasyk, S., Bloor, C.M., Khouri, E.M., and Gregg, D.E.: Systemic and coronary effects of coronary artery occlusion in the unanesthetized dog. Am. J. Physiol. 220:646, 1971.
McGregor, M., and Fam, W.M.: Regulation of coronary blood flow. Bull. N.Y. Acad. Med. 42:940, 1966.
Johnston, P.A., Huth, G.C., and Locker, R.J.: Low-energy radioactivity and avalanche semiconductor radiation detectors. Isotopes and Radiation Technology 7:266, 1970.
Herd, J.A., Hollenberg, M., Thorburn, G.D., Kopold, H.H., and Barger, A.C.: Myocardial blood flow determined with Krypton 85 in unanesthetized dogs. Am. J. Physiol. 203:122, 1962.
Linder, E.: Measurements of normal and collateral coronary blood flow by close-arterial and intramyocardial injection of 85Kr and 133Xe. Acta Physiol. Scand. 68(Suppl. 272):5, 1966.
Linder, E., and Seeman, T.: Effects of persantin and nitroglycerin on myocardial blood flow during temporary coronary occlusion in dogs. Angiologica 4:225, 1967.
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© 1973 Plenum Press, New York
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Khouri, E.M., Iza, A.R. (1973). The Effect of Glyceryl Trinitrate on Coronary Collateral Flow — A Preliminary Report. In: Bloor, C.M., Olsson, R.A. (eds) Current Topics in Coronary Research. Advances in Experimental Medicine and Biology, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9020-0_14
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DOI: https://doi.org/10.1007/978-1-4615-9020-0_14
Publisher Name: Springer, Boston, MA
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