Skip to main content

The Effect of Glyceryl Trinitrate on Coronary Collateral Flow — A Preliminary Report

  • Chapter
Current Topics in Coronary Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 39))

  • 43 Accesses

Abstract

There are many reports in the literature of the action of glyceryl trinitrate (GTN) on the coronary circulation. The effects have been studied on both the natural and the collateral circulation, using such techniques as direct flow measurement (1), radioisotope clearance (2), retrograde flow (3), peripheral pressure (4), pressure gradient (5), etc.; and there are as many explanations of the mode of action of the drug. This is a preliminary reports on the effects of GTN on the pre-existing coronary collateral vessels in the open chest dog. A beta ray detector affixed to the epicardial surface was used to obtain washout curves of 85Kr.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Khouri, E.M., Gregg, D.E., and Lowensohn, H.S.: Flow in the major branches of the left coronary artery during experimental coronary insufficiency in the unanesthetized dog. Circ. Res. 23:99, 1968.

    Article  PubMed  CAS  Google Scholar 

  2. Rees, R. J., Redding, V. J., Ashfield, R., Gibson, D., and Gavey, C.J.: Myocardial blood flow measurements with 133Xe Effect of glyceryl trinitrate in dogs. Brit. Heart J. 28:374, 1966.

    Article  PubMed  CAS  Google Scholar 

  3. Leighinger, D.S., Rueger, R., and Beck, C.S.: Effect of glyceryl trinitrate (nitroglycerin) on arterial blood supply to ischemic myocardium. Am. J. Cardiol. 3:638, 1959.

    Article  Google Scholar 

  4. Pasyk, S., Bloor, C.M., Khouri, E.M., and Gregg, D.E.: Systemic and coronary effects of coronary artery occlusion in the unanesthetized dog. Am. J. Physiol. 220:646, 1971.

    PubMed  CAS  Google Scholar 

  5. McGregor, M., and Fam, W.M.: Regulation of coronary blood flow. Bull. N.Y. Acad. Med. 42:940, 1966.

    PubMed  CAS  Google Scholar 

  6. Johnston, P.A., Huth, G.C., and Locker, R.J.: Low-energy radioactivity and avalanche semiconductor radiation detectors. Isotopes and Radiation Technology 7:266, 1970.

    CAS  Google Scholar 

  7. Herd, J.A., Hollenberg, M., Thorburn, G.D., Kopold, H.H., and Barger, A.C.: Myocardial blood flow determined with Krypton 85 in unanesthetized dogs. Am. J. Physiol. 203:122, 1962.

    PubMed  CAS  Google Scholar 

  8. Linder, E.: Measurements of normal and collateral coronary blood flow by close-arterial and intramyocardial injection of 85Kr and 133Xe. Acta Physiol. Scand. 68(Suppl. 272):5, 1966.

    Google Scholar 

  9. Linder, E., and Seeman, T.: Effects of persantin and nitroglycerin on myocardial blood flow during temporary coronary occlusion in dogs. Angiologica 4:225, 1967.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1973 Plenum Press, New York

About this chapter

Cite this chapter

Khouri, E.M., Iza, A.R. (1973). The Effect of Glyceryl Trinitrate on Coronary Collateral Flow — A Preliminary Report. In: Bloor, C.M., Olsson, R.A. (eds) Current Topics in Coronary Research. Advances in Experimental Medicine and Biology, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9020-0_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9020-0_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9022-4

  • Online ISBN: 978-1-4615-9020-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics