Abstract
In untreated polycythemia vera the plasma iron is normal or somewhat reduced. It may, however, be profoundly reduced as a result of spontaneous bleeding or regular venesection. Oral iron loading produces a steep rise of the plasma iron level (Pribilla and Wolfers, 1955).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Bibliography
Bateman, S. et al.: Splenic red cell pooling: a diagnostic feature in polycythaemia. Brit. J. Haemat. 40, 389 (1978).
Berlin, N. I., Lawrence, J. H., Lee, H. C.: The life span of the red blood cell in chronic leukemia and polycythemia. Science 114, 385 (1951).
Bothwell, T. H., Finch, C. A.: Iron Metabolism. Little, Brown and Co., Boston 1962.
Bothwell, T. H., Callender, S., Mallett, B., Witts, L. J.: The study of erythropoiesis using tracer quantities of radioactive iron. Brit. J. Haemat. 2, 1 (1956).
Brunner, H. E.: Die Differentialdiagnose der Erythrocythämien durch Untersuchung der Ferro- und Erythrocytenkinetik mit radioaktivem Eisen und Chrom. Klin. Wschr. 43, 429 (1965).
Burger, T., Schmelzer, M.: Changes in erythropoiesis during the course of polycythaemia vera. Folia haemat. (Lpz.) 103, 726 (1976).
Doering, P., Lorenz, B.: Diagnostik der Osteomyeloreticulose bei Polycythämie mit Radioeisen. Folia haemat. (Frankfurt) N. F. 8, 346 (1963).
Dreyfus, J. C., Schapira, G.: Le fer. L’Expansion, Paris 1958.
Finch, C. A., Gibson, J. G., Peacock, W. C., Fluharty, R. G.: Iron metabolism. Utilization of intravenous radioactive iron. Blood 4, 905 (1949).
Hammersten, J. F., Whitecomb, W. H., Johnson, P. C., Lowell, J. R.: The hematologic adaptation of patients with hypoxia due to pulmonary emphysema. Amer. Rev. Tuberc. 78, 391 (1958).
Henry, J. A.: Études des modifications de l’érythropoïese dans la maladie de Vaquez traitée par le phosphore radioactif. Acta clin. belg. Suppl. 2 (1966).
Horst, W., Rösler, H., Villanueva-Meyer, H.: 201 Fälle von Polycythämie: P32-Behandlungs- ergebnisse, Untersuchungen zur Ferrokinetik (Cr51 und Fe59) und über erythropoetische Plasma faktoren vor, unter und nach Therapie. In: Keiderling, W., Hoffmann, G. (eds.): Radio-Isotope in der Hämatologie, p. 361. Schattauer, Stuttgart 1963.
Huff, R. L., Hennessy, T. G., Austin, R. E., Garcia, J. F., Roberts, B. M., Lawrence, J. H.: Plasma and red cell iron turnover in normal subjects and in patients having various hematopoietic disorders. J. clin. Invest. 29, 1041 (1950).
Jones, N. F., Payne, R. W., Hyde, R. D., Price, T. M.: Renal polycythaemia. Lancet 1, 299 (1960).
Keiderling, W., Reissner, I., Dischler, W., Hoffmann, G.: Klinische Studien über die Kinetik des. Eisens. In: Keiderling, W., Hoffmann, G. (eds.): Radio-Isotope in der Hämatologie. Schattauer, Stuttgart 1963.
Kiely, J. M., Stroebel, C. F., Haulon, D. G., Owen, C. A.: Clinical value of plasma-iron turnover rate in diagnosis and management of polycythemia. J. nucl. Med. 2, 1 (1961).
Lajtha, L. G.: The Use of Isotopes in Haematology. Blackwell, Oxford 1961.
Lawrence, J. H.: Polycythemia. Physiology, diagnosis and treatment based on 303 cases. In: Modern Medical Monographs. Grune and Stratton, New York-London 1955.
Lawrence, J. H., Elmlinger, P. J., Fulton, G.: Oxygen and the control of red cell production in primary and secondary polycythemia. Effects on the iron turnover patterns with Fe59 as tracer. Cardiologica 21, 337 (1952).
London, I. M., Shemin, D., West, R., Rittenberg, D.: Heme synthesis and red blood cell dynamics in normal humans and in subjects with polycythemia vera, sickle cell anemia and pernicious anemia. J. biol. Chem. 179, 463 (1949).
Najean, Y., Cacchione, R., Castro-Malaspina, H., Dresch, C.: Erythrokinetic studies in myelofibrosis: their significance for prognosis. Brit. J. Haemat. 40, 205 (1978).
Nathan, D. G., Berlin, N. I.: Studies of the production and life span of erythrocytes in myeloid metaplasia. Blood 14, 668 (1959).
Pollycove, M., Winchell, H. S., Lawrence, J. H.: Classification and evolution of patterns of erythropoiesis in polycythemia vera as studied by iron kinetics. Blood 28, 807 (1966).
Pribilla, W., Wolfers, H.: Das Verhalten des Serumeisens bei Polycythämikern vor und während der Behandlung mit radioaktivem Phosphor. Klin. Wschr. 33, 960 (1955).
Sharney, L., Schwartz, L., Wasserman, L. R., Port, S., Leavitt, D.: Pool systems in iron metabolism; with special reference to polycythemia vera. Proc. Soc. exp. Biol. Med. 87, 489 (1954).
Szur, L., Smith, M. D.: Red-cell production and destruction in myelosclerosis. Brit. J. Haemat. 7, 147 (1961).
Telfer, N., Schiffmann, N. L.: The differential diagnosis of the polycythemias by plasma iron turnover determination. Nucl.-Med. (Stuttg.) 3, 137 (1963).
Tubiana, M., Loiseau, J. P., Vallée, G.: L’évolution des polyglobulies essentielles. Intérêt des épreuves successives par le chrom et le fer radioactifs. Nouv. Rev.franç. Hémat. 5, 397 (1965).
Varela, J. E., Rochna, V. E. M., Carmena, A. O., Etcheverry, M. A., Kremenchuzky, S.: Polycythaemia vera. Results of repeated radioisotope studies in 53 patients during a five-year period. Nucl.-Med. (Stuttg.) 3, 1 (1963).
Wasserman, L. R., Rashkoff, I. A., Leavitt, D., Mayer, J., Port, S.: The rate of removal of radioactive iron from the plasma — an index of erythropoiesis. J. clin. Invest. 31, 32 (1952)
Rights and permissions
Copyright information
© 1983 Akadémiai Kiadó, Budapest
About this chapter
Cite this chapter
Bernát, I. (1983). Iron Metabolism in Polycythemia Vera and Secondary Polycythemias. In: Iron Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7308-1_26
Download citation
DOI: https://doi.org/10.1007/978-1-4615-7308-1_26
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-7310-4
Online ISBN: 978-1-4615-7308-1
eBook Packages: Springer Book Archive