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Erythrokinetics

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Iron Metabolism
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Abstract

A deeper insight into the quantitative aspects of red cell production and destruction has added to the better understanding of the pathomechanisms underlying the various forms of anemia. In clinical practice an estimate of the total erythropoiesis is obtained by measuring the erythroid/myeloid (E/M) ratio in the bone marrow and the plasma iron transport rate, whereas effective erythropoiesis can be estimated from the iron utilization and corrected reticulocyte count.

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Bibliography

  • Ashby, W.: Determination of the length of life of transfused blood corpuscles in man. J. Exp. Med. 29, 267 (1919).

    Article  PubMed  CAS  Google Scholar 

  • Barrett, P. V. D., Berk, P. D., Menken, M., Berlin, N. I.: Bilirubin turnover studies in normal and pathologic states using bilirubin-14C. Ann. intern. Med. 68, 355 (1968).

    PubMed  CAS  Google Scholar 

  • Barrett, P. V. D., Cline, M. J., Berlin, N. I.: The association of the urobilin “early peak” and erythropoiesis in man. J. clin. Invest. 45, 1657 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Barrett, P. V. D., Mullino, F. X., Berlin, N. I.: Studies on the biosynthetic production of bilirubin- C14, an improved method utilizing delta-amino levulinic acid-4-C14 in dogs. J. Lab. clin. Med. 68, 905 (1966).

    PubMed  CAS  Google Scholar 

  • Berk, P. D., Howe, R. B., Bloomer, J. R., Berlin, N. I.: Studies of bilirubin kinetics in normal adults. J. clin. Invest. 48, 2176 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Berk, P. D., Howe, R. B., Bloomer, J. R., Berlin, N. I.: The life span of the red cell as determined with labeled bilirubin. In: Greenwalt, T. J., Jamieson, G. A. (eds.): Formation and Destruction of Blood Cells. Lippincott, Philadelphia-Toronto 1970.

    Google Scholar 

  • Berlin, N. L.: Life span of the red cell. In: Bishop, C., Surgenor, D. M. (eds.): The Red Blood Cell, pp. 423–450. Academic Press, New York 1964.

    Google Scholar 

  • Berlin, N. I., Waldmann, T. A., Weissman, S. M.: Life span of red blood cell. Physiol. Rev. 39, 577 (1959).

    PubMed  CAS  Google Scholar 

  • Bernát, I.: Az égési anaemia pathogenesise (The Pathogenesis of Anemia after Thermal Injury). Akadémiai Kiadó, Budapest 1971.

    Google Scholar 

  • Bernát, I., Cornides, I.: Stabil izotôpok alkalmazâsa a biolôgiai-orvosi kutatásban (The use of stable isotopes in biological-medical research). Honvédorvos 22, 201 (1970).

    Google Scholar 

  • Bothwell, T. H., Finch, C. A.: Iron Metabolism. Little, Brown and Co., Boston 1962.

    Google Scholar 

  • Box, H. C., Schenk, W. C., Wiles, C. E.: Biophysical methods for the assay of life span of red cells. Science 118, 72 (1953).

    Article  PubMed  CAS  Google Scholar 

  • Brown, A. K., Zuelzer, W. W., Burnett, H. H.: Studies on the neonatal development of the glucuronide conjugating system. J. clin. Invest. 37, 332 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Cline, M. J., Berlin, N. I.: An evaluation of DFP32 and Cr51 as methods of measuring red-cell life span in man. Blood 22, 459 (1963).

    PubMed  CAS  Google Scholar 

  • Cooper, R. A., Jandl, J. H.: Destruction of erythrocytes. In: Williams, W. J., Beutler, E., Erslev, R. W. (eds.): Hematology. McGraw-Hill Book Co., New York 1972.

    Google Scholar 

  • Dearing, W. H., Needham, G. M., Mason, H. L.: The effect of oral antibiotics on the intestinal bacteria and the formation of urobilinogen. Proc. Mayo Clin. 33, 646 (1958).

    CAS  Google Scholar 

  • Donaldson, G. U., Johnson, P. F., Tothill, P.: Red cell survival time in man measured by 50Cr and activation analysis. Brit. Med. J. 2, 585 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Donohue, D. M., Motulsky, A. G., Giblett, E. R., Pirzio-Biroli, G., Viranuvati, V., Finch, C. A.: The use of chromium as a red-cell tag. Brit. J. Haemat. 1, 249 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Dreyfus, J. C., Schapira, G.: Le fer. L’Expansion, Paris 1958.

    Google Scholar 

  • Finch, C. A.: Some quantitative aspects of erythropoiesis. Ann. N. Y. Acad. Sci. 77, 410 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Finch, C. A., Coleman, D. H., Motulsky, A. G., Donohue, D. M., Reiff, R. H.: Erythrokinetics in pernicious anemia. Blood 77, 807 (1956).

    Google Scholar 

  • Garby, L.: Analysis of red-cell survival curves in clinical practice and the use of di-iso-propylfluorophosphonate (DF32P) as a label for red cells in man. Brit. J. Haemat. 8, 15 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Giblett, E. R., Coleman, D. H., Pirzio-Biroli, G., Donohue, D. M., Motulsky, A. G., Finch, C. A.: Erythrokinetics. Quantitative measurements of red-cell production and destruction in normal subjects and patients with anemia. Blood 77, 291 (1956).

    Google Scholar 

  • Hallberg, L.: Blood volume, hemolysis and regeneration of blood in pernicious anemia. Studies based on the endogeneous formation of carbon monoxide and determination of the total amount of hemoglobin. Scand. J. clin. Lab. Invest. 7 (Suppl. 6), 1 (1955).

    PubMed  Google Scholar 

  • Heilmeyer, L., Oetzel, W.: Blutfarbstoffwechselstudien. II. Dtsch. Arch. klin. Med. 777, 365 (1931).

    Google Scholar 

  • Howe, R. B., Berk, P. D., Bloomer, J. R., Berlin, N. I.: Preparation and properties of specifically labeled radiochemically stable 3H-bilirubin. J. Lab. clin. Med. 75, 499 (1970).

    PubMed  CAS  Google Scholar 

  • Hurley, T. H., Weisman, R.: The determination of the survival of transfused red cells by a method of differential hemolysis. J. clin. Invest. 33, 835 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Committee for the Standardization in Haematology: Recommended methods for radioisotope red-cell survival studies. Blut 25, 108 (1972).

    Article  Google Scholar 

  • Lajtha, L. G.: The Use of Isotopes in Haematology. p. 22. Blackwell, Oxford 1961.

    Google Scholar 

  • London, I. M., Shemin, D., West, R., Rittenberg, D.: Heme synthesis of red blood cells; dynamics in normal humans and in subjects with polycythemia vera, sickle-cell anemia and pernicious anemia. J. biol. Chem. 779, 463 (1949).

    Google Scholar 

  • Nizet, A.: Recherches sur la Physiopathologie des hématies; la réticulocytose et la libération de hématies à partir de la moelle osseuse. Acta med. scand. 124, 590 (1946).

    Article  Google Scholar 

  • Penner, J. A.: Investigation of erythrocyte turnover with selenium-75-labeled methionin. J. Lab. Clin. Med. 67, 427(1966).

    PubMed  CAS  Google Scholar 

  • Reiff, R. H., Nutter, J. Y., Donohue, D. M., Finch, C. A.: The relative number of marrow reticulocytes. Amer. J. clin. Path. 30, 199 (1958).

    CAS  Google Scholar 

  • Rigas, J. (1961), cit. Bothwell, Finch, 1962.

    Google Scholar 

  • Schwartz, S.: Bilirubin Metabolism. Davis, Philadelphia 1967.

    Google Scholar 

  • Seip, M.: Reticulocyte studies. The liberation of red blood corpuscles from the bone marrow into the peripheral blood and the production of erythrocytes elucidated by reticulocyte investigations. Acta med. scand. 146 (Suppl. 282), 1 (1953).

    Google Scholar 

  • Shemin, D., Rittenberg, D.: The biological utilisation of glycine for the synthesis of the protoporphyrin of hemoglobin. J. biol. Chem. 166, 621 (1946a).

    PubMed  CAS  Google Scholar 

  • Shemin, D., Rittenberg, D.: The life span of the human red cell. J. biol. Chem. 166, 627 (1946b).

    PubMed  CAS  Google Scholar 

  • Sjöstrand, T.: A method for determination of carboxyhaemoglobin concentrations by analysis of the alveolar air. Acta physiol. scand. 16, 201 (1948).

    Article  Google Scholar 

  • Sjöstrand, T.: Endogenous formation of carbon monoxide in man under normal and pathologic conditions. Scand. J. clin. Lab. Invest. 7, 201 (1949a).

    Article  Google Scholar 

  • Sjöstrand, T.: Endogenous formation of carbon monoxide in man. Nature 164, 580 (1949b).

    Article  PubMed  Google Scholar 

  • Sjöstrand, T.: Endogenous formation of carbon monoxide. The CO concentration in the inspired and expired air of hospital patients. Acta physiol. scand. 22, 137 (1951).

    Article  PubMed  Google Scholar 

  • Strumia, M. M.: The life span of erythrocytes and their post-transfusional survival. In: Tocantins, L. M. (ed.): Progress in Hematology, Vol. 1. Grune and Stratton, New York-London 1956.

    Google Scholar 

  • Wintrobe, M. M.: Clinical Haematology. 7th ed., p. 198. Lea and Febiger, Philadelphia 1974.

    Google Scholar 

  • Young, L. E., Lawrence, J. S.: Maturation and destruction of transfused human reticulocytes. J. clin. Invest. 24, 554 (1945).

    Article  PubMed  CAS  Google Scholar 

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© 1983 Akadémiai Kiadó, Budapest

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Bernát, I. (1983). Erythrokinetics. In: Iron Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7308-1_15

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  • DOI: https://doi.org/10.1007/978-1-4615-7308-1_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7310-4

  • Online ISBN: 978-1-4615-7308-1

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