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Mechanisms of Nonspecific Host Resistance

  • Chapter
Immunodermatology

Part of the book series: Comprehensive Immunology ((COMIMUN,volume 7))

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Abstract

A major function of the immune system is the maintenance of the complex biochemical integrity of the host through protection against the penetration and/or the dissemination of biologically active environmental antigens such as microbial agents. The immune system also may play an important role in surveillance against the development and spread of cancer. In order to perform its functions, the immune system must recognize foreign materials and then efficiently eliminate the antigenic substances (Fig. 1). The actual elimination of antigenic material is accomplished by specialized effector cells of the immune system termed “phagocytes.” These cells include polymorphonuclear leukocytes and fixed and wandering mononuclear phagocytes. The recognition of antigens by immunoglobulins and lymphocytes is specific in that these immune components can discriminate subtle differences among antigens. Recognition of antigen by phagocytes is, in general, far less specific. Phagocytes by themselves discriminate only self from nonself and not differences in various forms of nonself. Antigens which enter the circulation are normally removed by the fixed phagocytic cells of the reticuloendothelial system. In other areas of the body however, antigens must be eliminated by phagocytic wandering cells which migrate to an inflammatory focus.

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References

  • Aellig, A., Maillard, M., Phavorin, A., and Frei, J., 1977, The energy metabolism of the leukocyte. IX. Changes in the concentrations of the coenzymes NAD, NADH, NADP and NADPH in polymorphonuclear leukocytes during phagocytosis of Staphylococcus albus and due to the action of phospholipase C, Enzyme 22: 207 - 212.

    PubMed  CAS  Google Scholar 

  • Altman, L. C., Snyderman, R., Oppenheim, J. J., and Mergenhagen, S. E., 1973, A human mononuclear leukocyte chemotactic factor: Characterization, specificity and kinetics of production by homologous leukocytes, J. Immunol 110: 801 - 810.

    PubMed  CAS  Google Scholar 

  • Altman, L. C., Mackler, B. F., and Chassey, B. M., 1974, Physiochemical characterization of chemotactic lymphokines produced by human thymus derived (T) and bone marrow derived (B) lymphocytes, J. Reticuloendothel. Soc. Suppl 16: 15a.

    Google Scholar 

  • Aswanikumar, S., Corcoran, B., Schiffmann, E., Day, A. R., Freer, R. J., Showell, H. J., and Pert, C. B., 1977, Demonstration of a receptor on rabbit neutrophile for chemotactic peptides, Biochem. Biophys. Res. Commun 74: 810 - 817.

    Article  PubMed  CAS  Google Scholar 

  • Babior, B. M., Kipnes, R. S., and Curnutte, J. T., 1973, Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent, J. Clin. Invest 52: 741 - 744.

    Article  PubMed  CAS  Google Scholar 

  • Becker, E. L., and Showell, H. J., 1972, The effect of Cat+ and Mgz+ on the chemotactic responsiveness and spontaneous motility of rabbit polymorphonuclear leukocytes, Z. Immunitaetsforsch. Exp. Klin. Immunol 143: 466 - 476.

    CAS  Google Scholar 

  • Becker, E. L., Davis, A. T., Estensen, R. D., and Quie, P. G., 1972, Cytochalasin B. IV. Inhibition and stimulation of chemotaxis of rabbit and human polymorphonuclear leukocytes, J. Immunol 108: 396 - 402.

    PubMed  CAS  Google Scholar 

  • Berlin, R. D., and Fera, J. P., 1977, Changes in membrane microviscosity associated with phagocytosis: Effects of colchicine, Proc. Natl. Acad. Sci. USA 74: 1072 - 1076.

    Article  PubMed  CAS  Google Scholar 

  • Boetcher, P. A., and Leonard, E., 1973, Basophil chemotaxis: Augmentation by a factor from stimulated lymphocyte cultures, Immunol. Commun 2: 421 - 429.

    PubMed  CAS  Google Scholar 

  • Bokisch, V. A., Müller-Eberhard, H. J., and Cochrane, C. G., 1969, Isolation of a fragment (C3a) of the third component of human complement containing anaphylatoxin and chemotactic activity and discription of an anaphylatoxin inactivator of human serum, J. Exp. Med 129: 1109 - 1130.

    Article  PubMed  CAS  Google Scholar 

  • Boucek, M. M., and Snyderman, R., 1976, Calcium influx requirement for human neutrophil chemotaxis: Inhibition by lanthanum chloride, Science 193: 905 - 907.

    Article  PubMed  CAS  Google Scholar 

  • Boxer, L. A., Hedley-Whyte, E. T., and Stossel, T. P., 1974, Neutrophil actin dysfunction and abnormal neutrophil behavior, N. Engl. J. Med 291: 1093 - 1099.

    Article  PubMed  CAS  Google Scholar 

  • Boxer, L. A., Richardson, S., and Floyd, A., 1976, Identification of actin binding protein in membrane of polymorphonuclear leukocytes, Nature (London) 263: 249 - 251.

    Article  CAS  Google Scholar 

  • Boyden, S., 1962, The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leukocytes, J. Exp. Med 115: 453 - 466.

    Article  PubMed  CAS  Google Scholar 

  • Bryant, R. E., DesPrez, R. M., VanWay, M. H., and Rogers, D. E., 1966, Studies on leukocyte motility. I. Effects of alterations of pH, electrolyte concentration and phagocytosis on leukocyte migration, adhesiveness and aggregation, J. Exp. Med 124: 483 - 499.

    Article  PubMed  CAS  Google Scholar 

  • Bryant, R. E., DesPrez, R. M., and Rogers, D. E., 1967, Studies on human leukocyte motility. II. Effects of bacterial endotoxin on leukocyte migration, adhesiveness, and aggregation, Yale J. Biol. Med 40: 192 - 203.

    PubMed  CAS  Google Scholar 

  • Carruthers, B. M., 1966, Leukocyte motility. I. Method of study, normal variation, effect of physical alterations in environment and effect of iodoacetate, Can. J. Physiol. Pharmacol 44: 475 - 485.

    Article  PubMed  CAS  Google Scholar 

  • Cline, M. J., 1965, Metabolism of the circulating leukocyte, Physiol. Rev 45: 674 - 720.

    PubMed  CAS  Google Scholar 

  • Cline, M. J., 1966, Ribonucleic acid biosynthesis in human leukocytes: Effects of phagocytosis on RNA metabolism, Blood 28: 188 - 200.

    PubMed  CAS  Google Scholar 

  • Cline, M. J., 1975, Chemotaxis, phagocytosis and micro-bial killing, in: The White Cell ( M. J. Cline, ed.), Harvard University Press, Cambridge, Mass.

    Google Scholar 

  • Cohen, S. Ward, P. A., Toshida, T., and Burek, C. L., 1973, Biologic activity of extracts of delayed hypersensitivity skin reaction sites, Cell. Immunol 9: 363 - 376.

    Article  PubMed  CAS  Google Scholar 

  • Cohn, Z. A., and Morse, S. I., 1960, Functional and metabolic properties of polymorphonuclear leukocytes. I. Observations on the requirements and consequences of particle ingestion, J. Exp. Med 111: 667 - 677.

    Article  PubMed  CAS  Google Scholar 

  • Corbin, N. C., and Hugh, T. E., 1976, The primary structure of porcine C3a anaphylatoxin, J. Immunol 117: 990 - 995.

    PubMed  CAS  Google Scholar 

  • Durham, A. C. H., 1974, A unified theory of the control of actin and myosin in nonmuscle movements, Cell 2: 123136.

    Google Scholar 

  • Eisbach, P., 1968, Increased synthesis of phospholipids during phagocytosis, J. Clin. Invest 47: 2217 - 2229.

    Article  Google Scholar 

  • Elsbach, P., 1972, Lipid metabolism by phagocytes, Semin. Hematol 9: 227 - 239.

    PubMed  CAS  Google Scholar 

  • Fernandez, H. N., and Hugli, T. E., 1976, Partial characterization of human C5a anaphylatoxin. I. Chemical description of the carbohydrate and polypeptide portions of human C5a, J. Immunol 117: 1688 - 1694.

    PubMed  CAS  Google Scholar 

  • Fernandez, H. N., Henson, P. M., Otani, A., and Hugh, T. E., 1978, Chemotactic response to human C3a and C5a anaphylatoxins. I. Evaluation of C3a and C5a leukotaxis in vitro and under simulated in vivo conditions, J. Immunol 120: 109 - 115.

    PubMed  CAS  Google Scholar 

  • Frank, M. M., Schreiber, A. D., Atkinson, J. P., and Jaffe, C. J., 1977, Pathophysiology of immune hemolytic anemia, Ann. Int. Med 87: 210 - 222.

    Google Scholar 

  • Fredovich, I., 1974, Superoxide dismutases, Adv. Enzymol 41: 35 - 98.

    Google Scholar 

  • Gatlin, J. I., 1975, Abnormal chemotaxis: Cellular and humoral components, in: The Phagocytic Cell in Host Resistance ( J. A. Bellanti and D. H. Dayton, eds.), pp. 227 - 249, Raven Press, New York.

    Google Scholar 

  • Gatlin, J. I., and Rosenthal, A. S., 1974, The regulatory role of divalent cations in human granulocyte chemotaxis: Evidence for an association between calcium exchanges and microtubule assembly, J. Cell Biol 62: 594 - 609.

    Article  Google Scholar 

  • Gatlin, J. I., and Wolff, S. M., 1975, Leukocyte chemotaxis: Physiological considerations and abnormalities, Clin. Haematol 4: 567 - 607.

    Google Scholar 

  • Gatlin, J. I., Clark, R. A., and Kimball, H. R., 1973, Granulocyte chemotaxis. An improved in vitro assay employing 51Cr-labeled granulocytes, J. Immunol 110: 233 - 240.

    Google Scholar 

  • Goetzl, E. J., and Austen, K. F., 1972, A method for assessing the in vitro chemotactic response of neutrophils utilizing 51Cr-labeled human leukocytes, Immunol. Commun 1: 421 - 430.

    PubMed  CAS  Google Scholar 

  • Goetzl, E. J., and Austen, K. F., 1974, Stimulation of human neutrophil leukocyte aerobic glucose metabolism by purified chemotactic factors, J. Clin. Invest 53: 591 - 599.

    Article  PubMed  CAS  Google Scholar 

  • Goetzl, E. J., Wasserman, S. I., Gigli, I., and Austen, K. F., 1974, Enhancement of random migration and chem-otactic response of human leukocytes by ascorbic acid, J. Clin. Invest 53: 813 - 818.

    Article  PubMed  CAS  Google Scholar 

  • Hartwig, J. H., and Stossel, T. P., 1975, Isolation and properties of actin, myosin, and a new actin binding protein in rabbit alveolar macrophages, J. Biol. Chem 250: 5696 - 5705.

    PubMed  CAS  Google Scholar 

  • Hugh, T. E., Vallota, E. H., and Müller-Eberhard, H. J., 1975, Purification and partial characterization of human and porcine C3a anaphylatoxin, J. Biol. Chem 250: 1472 - 1478.

    Google Scholar 

  • Jensen, J., Snyderman, R., and Mergenhagen, S. E., 1969, Chemotactic activity: A property of guinea pig C5 anaphylatoxin, in: Cellular and Humoral Mechanisms in Anaphylaxis and Allergy ( H. Z. Movat, ed.), pp. 265 - 278, Karger, Basel.

    Google Scholar 

  • Jensen, M. S., and Bainton, D. F., 1973, Temporal changes in pH within the phagocytic vacuole of the polymorphonuclear neutrophilic leukocyte, J. Cell Biol 56: 379 - 388.

    Article  PubMed  CAS  Google Scholar 

  • Johnston, R. B., Jr., and Baehner, R. L., 1971, Chronic granulomatouse disease: Correlation between pathogenesis and clinical findings, Pediatrics 48: 730 - 739.

    PubMed  Google Scholar 

  • Karnovsky, M. L., 1962, Metabolic basis of phagocytic activity, Physiol. Rev 42: 143 - 168.

    PubMed  CAS  Google Scholar 

  • Karnovsky, M. L., and Wallach, D. F. H., 1961, The metabolic basis of phagocytosis. III. Incorporation of inorganic phosphate into various classes of phosphatides during phagocytosis, J. Biol. Chem 236: 1895 - 1901.

    PubMed  CAS  Google Scholar 

  • Keller, H. U., and Sorkin, E., 1965, On the chemotactic and complement fixing activity of gammaglobulins, Immunology 9: 241 - 248.

    PubMed  CAS  Google Scholar 

  • Keller, H. U., and Sorkin, E., 1967, Studies on chemotaxis. V. On the chemotactic effect of bacteria, J. Arch. Allergy Appl. Immunol 31: 505 - 517.

    Article  Google Scholar 

  • Klebanoff, S. J., 1975, Antimicrobial systems of the polymorphonuclear leukocyte, in: The Phagocytic Cell in Host Resistance ( J. A. Bellanti and D. H. Dayton, eds.), pp. 45 - 59. Raven Press, New York.

    Google Scholar 

  • Mackler, B. F., Altman, L. C., Rosenstreich, D. L., and Oppenheim, J. J., 1974, Inducton of lymphokine production by EAC and of blastogenesis by soluble mitrogens during human B cell activation, Nature (London) 249: 834 - 837.

    Article  CAS  Google Scholar 

  • Metchnikoff, E., 1893, Lectures on the comparative pathology of inflammation (Kegan Paul, London); quoted by J. H Hirsch, in Phagocytosis, Annu. Rev. Microbio. 19: 339 - 370.

    Google Scholar 

  • Miller, M. E., and Nilsson, U. F., 1970, A familial deficiency of the phagocytosis enhancing activity of serum related to a dysfunction of the fifth component of complement (C5), N. Engl. J. Med 282: 354 - 358.

    Article  PubMed  CAS  Google Scholar 

  • Nelson, R. D., Quie, P. G., and Simmons, R. L., 1975, Chemotaxis under agarose: A new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and mono-cytes, J. Immunol 115: 1650 - 1656.

    PubMed  CAS  Google Scholar 

  • Oliver, J. M., Ukena, T. E., and Berlin, R. D., 1974, Effect of phagocytosis and colchicine on the distribu-tion of lectin-binding sites on cell surfaces, Proc. Natl. Acad. Sci. USA 71: 394 - 398.

    Article  PubMed  CAS  Google Scholar 

  • Paul, B., and Sbarra, A. J., 1968, The role of the phagocyte in host-parasite interactions. XIII. The direct quantitative estimation of 112O2 in phagocytizing cells, Biochim. Biophys. Acta 156: 168 - 178.

    Article  PubMed  CAS  Google Scholar 

  • Phelps, P., 1969, Polymorphonuclear leukocyte motility in vitro. III. Possible release of a chemotactic substance after phagocytosis of urate crystals by polymorphonuclear leukocytes, Arthr. Rheum 12: 197 - 204.

    Article  CAS  Google Scholar 

  • Phelps, P., 1970, Polymorphonuclear leukocyte motility in vitro. IV. Colchicine inhibition of the formation of chemotactic activity after phagocytosis of urate crystals, Arthr. Rheum 13: 1 - 9.

    Article  CAS  Google Scholar 

  • Pike, M. C., and Daniels, C. A., 1975, Production of C5a upon the interaction of staphylococcal protein A with human serum, Fed. Proc 34: 853A.

    Google Scholar 

  • Pike, M. C., and Snyderman, R., 1976, Augmentation of human monocyte chemotactic response by levamisole, Nature (London) 261: 136 - 137.

    Article  CAS  Google Scholar 

  • Postlethwaite, A. E., and Snyderman, R., 1975, Characterization of chemotactic activity produced in vivo by a cell mediated immune reaction in the guinea pig, J. Immunol 114: 274 - 278.

    PubMed  CAS  Google Scholar 

  • Quie, P. G., White, J. G., Holmes, B., and Good, R. A., 1%7, In vitro bactericidal capacity of human polymorphonuclear leukocytes: Diminished activity in chronic granulomatous disease of childhood, J. Clin. Invest 46:668-679.

    Google Scholar 

  • Ramsey, W. S., 1972, Analysis of individual leukocyte behavior during chemotaxis, Exp. Cell Res 70: 120 - 139.

    Article  Google Scholar 

  • Rebuck, J. W., and Crowley, J. H., 1955, A method for studying leukocyte function in vivo, Ann. NY Acad. Sci 59: 757 - 805.

    Article  PubMed  CAS  Google Scholar 

  • Schiffmann, E., Corcoran, B. A., and Wahl, S. M., 1975, N-Formylmethionyl peptides are chemotactic for polymorphonuclear leukocytes, Proc. Natl. Acad. Sci. USA 72: 1059 - 1062.

    Article  PubMed  CAS  Google Scholar 

  • Shin, H. S., Snyderman, R., Friedman, E., Mellors, A., and Mayer, M. M., 1968, Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement, Science 162: 361 - 363.

    Article  PubMed  CAS  Google Scholar 

  • Shin, H. S., Gewurz, H., and Snyderman, R., 1969, Reaction of cobra venom factor with guinea pig complement and generation of an activity chemotactic for polymorphonuclear leukocytes, Proc. Soc. Exp. Biol. Med 131: 203 - 207.

    PubMed  CAS  Google Scholar 

  • Showell, H. J., Freer, R. J., Zigmond, S. H., Schiffman, E., Aswanikumar, S., Corcoran, B., and Becker, E. L., 1976, The structure activity relations of synthetic peptides as chemotactic factors and inducers of lysosomal enzyme secretion for neutrophils, J. Exp. Med 143: 1154 - 1169.

    Article  PubMed  CAS  Google Scholar 

  • Snyderman, R., and Pike, M. C., 1978, Pathophysiologic aspects of leukocyte chemotaxis: Identification of a specific chemotactic factor binding site on human granulocytes and defects of macrophage function associated with neoplasia, in: Leukocyte Chemotaxis ( P. G. Quie and J. I. Gatlin, eds.), pp. 357 - 378, Raven Press, New York.

    Google Scholar 

  • Snyderman, R., Gewurz, H., and Mergenhagen, S. E., 1968, Interactions of the complement system with endotoxic lipopolysaccharide. Generation of a factor chemotactic for polymorphonuclear leukocytes, J. Exp. Med 128: 259 - 275.

    Article  PubMed  CAS  Google Scholar 

  • Snyderman, R., Phillips, J. K., and Mergenhagen, S. E., 1970, Polymorphonuclear leukocyte chemotactic activity in rabbit serum and guinea pig serum treated with immune complexes. Evidence for C5a as the major chemotactic factor. Infect. Immun 1: 521 - 525.

    PubMed  CAS  Google Scholar 

  • Snyderman, R., Phillips, J. K., and Mergenhagen, S. E., 1971a, Biological activity of complement in vivo: Role of C5 in the accumulation of polymorphonuclear leukocytes in inflammatory exudates, J. Exp. Med 134: 1131 - 1143.

    Article  PubMed  CAS  Google Scholar 

  • Snyderman, R., Shin, H. S., and Hausman, M. S., 1971b, A chemotactic factor for mononuclear leukocytes, Proc. Soc. Exp. Biol. Med 138: 387 - 390.

    PubMed  CAS  Google Scholar 

  • Snyderman, R., Altman, L. C., Hausman, M. S., and Mergenhagen, S. E., 1972. Human mononuclear leukocyte chemotaxis: A quantitative assay for mediators of humoral and cellular chemotactic factors, J. Immunol 108: 857 - 860.

    PubMed  CAS  Google Scholar 

  • Snyderman, R., Pike, M. C., McCarley, D., and Lang, L., 1975, Quantification of mouse macrophage chemotaxis in vitro: Role of C5 for the production of chemotactic activity, Infect. Immun 11: 488 - 492.

    PubMed  CAS  Google Scholar 

  • Snyderman, R., Pike, M. C., Blaylock, B., and Weinstein, P., 1976, Effect of neoplasms on inflammation: Depression of macrophage accumulation following tumor implantation, J. Immunol 116: 585 - 589.

    PubMed  CAS  Google Scholar 

  • Snyderman, R., Meadows, L., and Amos, D. B., 1977a, Characterization of human chemotactic lymphokine production induced by mitogens and mixed leukocyte reactions using a new microassay, Cell. Immunol 30: 225 - 235.

    Article  PubMed  CAS  Google Scholar 

  • Snyderman., R., Pike, M. C., Szatalowicz, V., and Meadows, L., 1977b, A familial deficiency of the fifth component of complement, Clin. Res 25: 368A.

    Google Scholar 

  • Stretcher, V. J., and Sorkin, E., 1969, Studies on chemotaxis. XII. Generation of chemotactic activity for polymorphonuclear leukocytes in sera with complement deficiencies, Immunology 16: 231 - 239.

    Google Scholar 

  • Stossel, T. P., 1973, Quantitative studies of phagocytosis: Kinetic effects of cations and heat-labile opsonins, J. Cell Biol 58: 346 - 356.

    Article  PubMed  CAS  Google Scholar 

  • Stossel, T. P., 1977, Contractile proteins in phagocytosis: An example of cell surface-to-cytoplasm communication, Fed. Proc 36: 2181 - 2184.

    PubMed  CAS  Google Scholar 

  • Stossel, T. P., and Hartwig, J. H., 1975, Interactions between actin, myosin, and an actin binding protein from rabbit alveolar macrophages, J. Biol. Chem 250: 5706 - 5712.

    PubMed  CAS  Google Scholar 

  • Stossel, T. P., and Pollard, T. D., 1973, Myosin in polymorphonuclear leukocytes, J. Biol. Chem 248: 8288 - 8294.

    PubMed  CAS  Google Scholar 

  • Stossel, T. P.., Mason, R. J., Hartwig, J , and Vaughn, M., 1971, Quantitative studies of phagocytosis by polymorphonuclear leukocytes. Use of parafin oil emulsions to measure the rate of phagocytosis, J. Clin. Invest 51: 615 - 624.

    Google Scholar 

  • Stossel, T. P., Hartwig, J. H., and Boxer, L. A., 1976, Contractile proteins and the mechanism of phagocytosis, in: Contractile Systems in Non Muscle Tissues ( S. V. Perry, ed.), pp. 323 - 329, Elsevier/North-Holland Biomedical Press, Amsterdam.

    Google Scholar 

  • Tatsumi, N., Shibata, N., and Okamura, Y., 1973, Actin and Myosin A from leukocytes, Biochim. Biophys. Acta 305: 433 - 444.

    Article  PubMed  CAS  Google Scholar 

  • Taylor, F. B., and Ward, P. A., 1967, Generation of chemotactic activity in rabbit serum by plasminogen-streptokinase mixtures, J. Exp. Med 126: 149 - 158.

    Article  PubMed  CAS  Google Scholar 

  • Trippestad, A., and Midtvedt, T., 1968, Phagocytosis of 32P-labeled E. coli by rat peritoneal polymorphonuclear leukocytes, Acta Pathol. Microbiol. Scand 74: 259 - 273.

    Article  PubMed  CAS  Google Scholar 

  • Turner, S. R., Campbell, J. A., and Lynn, W. S., 1975, Polymorphonuclear leukocyte chemotaxis towards oxidized lipid components of cell membranes, J. Exp. Med. 141: 1437 - 1441.

    CAS  Google Scholar 

  • Van Breeman, C., Farinas, B. R., Garba, P., and Mc-Naughton, E. D., 1972, Excitation-contraction coupling in rabbit aorta studies by the lanthanum method for measuring cellular calcium influx, Circ. Res 30: 44 - 54.

    Article  Google Scholar 

  • Wahl, S. M., Iverson, G. M., and Oppenheim, J. J., 1974, Induction of guinea pig B-cell lymphokine synthesis by mitogenic and non-mitogenic symbols to Fc, Ig and C3 receptors, J. Exp. Med 140: 1631 - 1645.

    Article  PubMed  CAS  Google Scholar 

  • Wahl, S. M., Wilton, J. M., Rosenstreich, D. L., Oppenheim, J. J., 1975, The role of macrophages in the production of lymphokines by T and B lymphocytes, J. Immunol 114: 1296 - 1301.

    PubMed  CAS  Google Scholar 

  • Walker, W. S., Bartlett, R. L., and Kurtz, H. M., 1969, Isolation and partial characterization of a staphylococcal leukocyte cytotaxin, J. Bacteriol 97: 1005 - 1008.

    PubMed  CAS  Google Scholar 

  • Ward, P. A., 1966, The chemosuppression of chemotaxis, J. Exp. Med 124: 209 - 225.

    Article  PubMed  CAS  Google Scholar 

  • Ward, P. A., Cochrane, C. G., and Müller-Eberhard, 1965, The role of serum complement in chemotaxis of leukocytes in vitro, J. Exp. Med 122: 327 - 346.

    Article  PubMed  CAS  Google Scholar 

  • Ward, P. A., Cochrane, C. G., and Müller-Eberhard, H. J., 1966, Further studies on the chemotactic factor of complement and its formation in vivo, Immunology 11: 141 - 153.

    PubMed  CAS  Google Scholar 

  • Ward, P. A., Lepow, I. H., and Newman, L. J., 1968, Bacterial factors chemotactic for polymorphonuclear leukocytes, Am. J. Pathol 52: 725 - 736.

    PubMed  CAS  Google Scholar 

  • Ward, P. A., Remold, H. G., and David, J. R., 1969, Leukotactic factors produced by sensitized lymphocytes, Science 163: 1079 - 1081.

    Article  PubMed  CAS  Google Scholar 

  • Ward, P. A., Remold, H. G., and David, J. R., 1970, The production from antigen-stimulated lymphocytes of a leukotactic factor distinct from migration inhibitory factor, Cell. Immunol 1: 162 - 174.

    Article  PubMed  CAS  Google Scholar 

  • Watterson, D. M., and Snyderman, R., 1977, unpublished.

    Google Scholar 

  • Wessells, H. K., Spooner, B. S., Ash, J. F., Bradley, M. O., Ludena, M. A., Taylor, E. L., Wrenn, J. T. and Yamada, K. M., 1971, Microfilaments in cellular and developmental processes, Science 171: 135 - 143.

    Article  PubMed  CAS  Google Scholar 

  • Wilkinson, P. C., 1974a, Principles of the measurement of leukocyte chemotaxis using Boyden's method, in: Chemotaxis and Inflammation (P. C. Wilkinson, ed.), pp. 33 - 53, Churchill-Livingstone, Edinburgh.

    Google Scholar 

  • Wilkinson, P. C., 19746, Classification of chemotactic factors, in: Chemotaxis and Inflammation (P C. Wilkinson, ed.), pp. 54-60, Churchill-Livingstone, Edinburgh.

    Google Scholar 

  • Williams, L. T., Snyderman, R., Pike, M. C., and Lefkowitz, R. J., 1977, Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes, Proc. Natl. Acad. Sci. USA 74: 1204 - 1208.

    Article  PubMed  CAS  Google Scholar 

  • Wright, D. G., and Gallin, J. I., 1975, Modulation of the inflammatory response by products released from human polymorphonuclear leukocytes during phagocytosis: Generation and inactivation of the chemotactic factor CSA, Inflammation 1: 23 - 39.

    Article  Google Scholar 

  • Zigmond, S. H., and Hirsch, J. G., 1973, Leukocyte locomotion and chemotaxis: New methods for evaluation and demonstration of a cell-derived chemotactic factor, J. Exp. Med 137: 387 - 410.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. The Laboratory of Immune Effector Function of the Howard Hughes Medical Institute in the Division of Rheumatic and Genetic Diseases, Departments of Medicine and Immunology and Microbiology, Duke University Medical Center, Durham, North Carolina, 27710, USA

    Ralph Snyderman & Marilyn C. Pike

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  1. Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Bijan Safai M.D.  & Robert A. Good Ph.D., M.D.  & 

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Snyderman, R., Pike, M.C. (1981). Mechanisms of Nonspecific Host Resistance. In: Safai, B., Good, R.A. (eds) Immunodermatology. Comprehensive Immunology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7228-2_5

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  • DOI: https://doi.org/10.1007/978-1-4615-7228-2_5

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