Abstract
The graft-vs.-host reaction (GVHR) occurs when immunologically competent cells are transfused or transplanted from one individual into another who is immunologically unable to react against foreign cells. Under experimental conditions, GVHR can be induced when immunologically competent cells are transferred to a recipient unresponsive because of immunological immaturity (e.g., newborn mice) or immunosuppressive therapy (e.g., following total-body irradiation), or because, in certain genetically defined situations, the recipient is unable to recognize genetic differences between self and donor (Simonsen, 1962; Billingham, 1966; Elkins, 1971; Grebe and Streilein, 1976). This occurs when an F1 hybrid mouse is grafted with marrow or spleen cells from either parent (i.e., P → F1 graft). The transplant cells from the parent, however, are stimulated by genetic differences expressed by tissues of the F1 recipient, and an aggressor reaction of grafted cells vs. host tissues results (Fig. 1). Several clinical situations exist wherein the transfusion of immunologically competent donor cells to an immunologically deficient recipient can cause GVHR. Patients with primary or secondary immune deficiency can be susceptible to the potential GVHR-inducing activity of lymphocytes present in transfused blood or transplanted bone marrow.
The research was aided by grants from USPHS (CA-08748, CA-17404, CA-19267, CA-23766, AI-11843, NS-11457, CA-18029, HL-17265), the Judith Harris Selig Memorial Fund, and the Zelda R. Weintraub Cancer Fund.
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Hansen, J.A., Woodruff, J.M., Good, R.A. (1981). The Graft-vs.-Host Reaction in Man. In: Safai, B., Good, R.A. (eds) Immunodermatology. Comprehensive Immunology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7228-2_15
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