Abstract
Two major types of immune response have been described in man. One type is mediated by thymus-derived (T) lymphocytes and is characterized by cellular interactions. The other type is produced by the activities of immunoglobulins secreted by bone marrow (B) lymphocytes when these have differentiated to become plasma cells. Since T-cell immunity requires cellular functions for both development and expression, this type of response has been termed cell-mediated immunity. In contrast, B-cell-associated immune response depends on immunoglobulins carried in the serum and has been called humoral immunity. T-cell immune functions include those effective in host defense against spread of certain infectious agents, contact sensitivity, allograft rejection, and graft-vs.-host disease. B-cell-associated immune responses provide protection against encapsulated bacteria and many viruses, participate in formation of immune complexes, are essential for antibody-mediated cytotoxicity, and affect many aspects of immune reactions through the production of specific antibodies. The ontogeny and development of T and B lymphocytes are described elsewhere. Humoral immunity and the specificity of immunoglobulin production by differentiated B cells are discussed in Chapter 3. In this chapter some characteristic features of cell-mediated immunity will be presented.
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References
Aiuti, F., and Wigzell, H., 1973, Function and distribution pattern of human T lymphocytes. I. Production of specific anti T lymphocyte sera as estimated by cytotoxicity and elimination of function of lymphocytes, Clin. Exp. Immunol. 13: 171–181.
Akira, D., and Takasugi, M., 1977, Loss of specific natural cell-mediated cytotoxicity with absorption of natural antibodies from serum, Int. J. Cancer 19: 747–755.
Alford, B. H., 1970, Metal cation requirements for phytohemagglutinin-induced transformation of human peripheral blood lymphocytes, J. Immunol. 104: 698–703.
Allan, D., and Crumpton, M. J., 1971, Fractionation of the phytohemagglutinin of Phaseolus vulgaris by polyacrylimide gel electrophoresis in sodium dodecyl sulfate, Biochem. Biophys. Res. Commun. 44: 1143–1148.
Allan, D., and Crumpton, M. J., 1973, Phytohemagglutinin-lymphocyte interaction: Characterization of binding sites on pig lymphocytes for 1251-labelled phytohemagglutinin, Exp. Cell Res. 78: 271–278.
Alwood, G., Asherson, G., Davey, M. J., and Goodford, P., 1970, The early uptake of radioactive calcium by human lymphocytes treated with phytohemagglutinin, Immunology 21: 509–516.
Alter, B., and Bach, F. H., 1970, Lymphocyte reactivity in vitro. I. Cellular reconstitution of purified lymphocyte response, Cell Immunol. 1: 207–218.
Armerding, D., and Katz, D.H., 1974, Activation of T and B lymphocytes in vitro. II. Biological and biochemical properties of an allogeneic effect factor (AEF) active in triggering specific B lymphocytes, J. Exp. Med. 140: 1937.
Andersen, V., Soborg, M., and Sorensen, S. F., 1971, Antigen-induced lymphocyte transformation in vitro during primary immunization in man, Acta. Path. Microbial Scand. Sect. B 79: 489–494.
Andersen, V., Hertz, J. B., Sorenson, S. F., Baekgarred, P., Christenson, P. E., Ramhoj, W., Hansen, G. A., Wardlaw, A. C., and Sato, Y., 1977, In vitro stimulation of human lymphocytes by Bordetella pertussis, Acta Pathol. Microbiol. Scand. Sect. C 85: 65–72.
Andersson, J., Edelman, G. M., Möller, G., and Sjoberg, O., 1972, Activation of B lymphocytes by locally concentrated Con A, Eur. J. Immunol. 2: 233–235.
Arbeit, R. D., Sachs, D. H., Amos, B., and Dickler, H. B., 1975, Human lymphocyte alloantigen(s) similar to murine Ir region-associated (Ia) antigens, J. Immunol. 115: 1173–1175.
August, C. S., Merler, E., Lucas, D. O., and Janeway, C. A., 1970, The response in vitro of human lymphocytes to phytohemagglutinin and to antigens after fractionation on discontinuous density gradients of albumin, Cell Immunol. 1: 603–618.
Averdunk, R., and Wenzel, B. 1978, Lymphocyte activation without mitogens by increasing the calcium concentration in the culture medium, In: Cell Biology and Immunology of Leukocyte Function (M. R. Quastel, ed.), Abstr. No. 11, pp. 79–83, Ben Gurion University, Israel
Ballet, J. J., 1978, Increasing expression of the capacity to bind sheep erythrocytes during in vitro differentiation and stimulation of human T lymphocytes, In: Proceedings of the 12th Leukocyte Culture Conference (M. Quastel, ed.), Abstr. No. 16, Ben Gurion University, Israel.
Bascoul, S., Peraldi, M., Merino, A. L., LaCare, C., Gannat, A., and Sorre, A., 1976, Stimulating activity of Brucella fractions in a human lymphocyte transformation test. Correlation with humoral and cellular immunity, Immunology 31: 717–722.
Bash, J. A. and Durkin, H. G., and Waksman, B. H., 1975, Kinetic study of T lymphocytes after sensitization against soluble antigen. III. Potentiation and suppression of the PHA response by antigen-activated lymphocytes of low density, J. Exp. Med. 142: 1017–1021.
Bean, M. A., Bloom, B. R., Herberman, R. B., Old, L. J., Oettgen, H. F., Klein, G., and Terry, W. D., 1975, Cell-mediated cytotoxicity for bladder carcinoma: Evaluation of a workshop, Cancer Res. 35: 2902–2913.
Bean, M. A., Kodera, Y., Cummings, K. B., and Bloom, B. R., 1977, Occurrence of restricted suppressor T-cell activity in man, J. Exp. Med. 146: 1455–1460.
Benezra, D., Gary, I., and Davies, A. M., 1967, Transformation of rabbit lymphocytes by specific antigens, Proc. Soc. Exp. Biol. Med. 125: 1305–1308.
Bennett, B., and Bloom, B. R., 1968, Reactions in vivo and in vitro produced by a soluble substance associated with delayed-type hypersensitivity, Proc. Natl. Acad. Sci. USA 59: 756–762.
Berger, A. E., and Amos, D. B., 1977, A comparison of antibody-dependent cellular cytotoxicity (ADCC) mediated by murine and human lymphoid cell populations, Cell Immunol. 33: 277–290.
Berger, N. A., and Skinner, A. M., 1974, Characterization of lymphocyte transformation induced by zinc ions, J. Cell Biol. 61: 45–55.
Bergholtz, B., and Thorsby, E., 1977, Macrophage-dependent response of immune human T lymphocytes to PPD in vitro, Scand. J. Immunol 6: 779–786.
Berlinger, N. T., Lopez, C., and Good, R. A., 1976, Facilitation or attenuation of mixed leukocyte culture responsiveness by adherent cells, Nature (London) 260: 145–146.
Betel, I., and Van den Berg, K. J., 1972, Interaction of Con A with rat lymphocytes, Eur. J. Biochem. 30: 571–578.
Bianco, C., Patrick, R., and Nussenzweig, V., 1970, A population of lymphocytes bearing a membrane receptor for antigen-antibody complement complexes, J. Exp. Med. 132: 702–720.
Biberfeld, P., 1971, Endocytosis and lysosome formation in blood lymphocytes transformed by PHA, J. Ultrastruct. Res. 37: 41–68.
Birnbaum, G., and Swick, L., 1978, Human suppressor lymphocytes. I. Induction and characterization, Cell. Immunol. 40: 16–27.
Blanden, R. V., 1971, Mechanisms of recovery from a generalized viral infection: Mouse pox. II. Passive transfer of recovery mechanisms with immune lymphoid cells, J. Exp. Med. 133: 1074.
Bona, C., and Paul, W. E., 1979, Cellular basis of regulation of expression of idiotype, I. T-suppressor cells specific for MOPC 460 idiotype regulate the expression of cells secreting anti TNP antibodies bearing 460 idiotype, J. Exp. Med. 149: 592–600.
Bona, C., Damass, C., Dimitra, A., Chedidi, L., Ciorbara, R., Adams, A., Petit, J. F., Lederer, E., and Rosselet, J. P., 1974, Mitogenic effect of a water soluble extract of Nocardia opaca. A comparison study with some bacterial adjuvants on spleen and peripheral lymphocytes of four mammalian species, J. Immunol. 112: 2028–2035.
Börjeson, J., Reisfeld, R., Chessin, L., Welsh, P. D., and Douglas, S. D., 1965, Studies on human peripheral blood lymphocytes in vitro. I. Biological and physicochemical properties of the pokeweed mitogen, J. Exp. Med. 124: 859–872.
Braendstrup, O., and Werdelin, O., 1977, Macrophage-lymphocyte clusters in the immune response to soluble protein antigen in vitro. IV. Synergy of lymphocytes in the formation of clusters, Cell. Immunol. 32: 263–273.
Broder, S., Humphrey, R., Durm, M., Blackman, M., Meade, B., Goldman, C., Strober, W., and Waldman, T., 1975, Impaired synthesis of polyclonal (non para protein) immunoglobuline by circulating lymphocytes from patients with multiple myeloma, N. Engl. J. Med. 293 (18): 887–892.
Broder, S., Poplack, D., Whang-Pend, J., Durm, M., Goldman, C., Mual, C., and Waldman, T. A., 1978, Characterization of a suppressor-cell leukemia: Evidence for the requirement of an interaction of two T cells in the development of human suppressor effector cells, N. Engl. J. Med. 297: 66–72.
Brown, G., and Greaves, M., 1973, Cell surface markers from human T and B lymphocytes, Eur. J. Immunol. 4: 302–310.
Bryan, C., Broxmeyer, H. E., Hansen, J. A., Pollack, M. S., and Dupont, B., 1978, Identification of an MLC suppressor cell in leukemia, Transplant. Proc. 10: 915–918.
Buckley, R. H., and McGeady, S. J., 1974, Studies of cell-mediated immune function in atopic eczema, J. Allergy Clin. Immunol. 53: 72–73.
Calder, E. A., Irvine, W. J., Davidson, N., M.D., and Wu, F., 1976, Ti Bi and K cells in autoimmune thyroid disease, Clin. Exp. Immunol. 25: 17–22.
Callewaert, D. M., Kaplan, J., Peterson, W. D., Jr., and Lightbody, J. J., 1977, Spontaneous cytotoxicity of human lymphoblast cell lines mediated by normal peripheral blood lymphocytes. 1. Differential susceptibility of T-versus B-cell lines, Cell Immunol. 33: 11–19.
Caron, G. A., 1967, The effects of concentration on antigen-induced lymphocyte transformation in vitro, Int. Arch. Allergy 31: 441–448.
Cerottini, S. C., Nordin, A. A., and Brunner, K. T., 1970, Specificity in in vitro cytotoxicity of thymus-derived lymphocytes sensitized to alloantigens, Nature (London) 228: 1308.
Chaparas, S. D., Sheagren, J. N., DeMeo, A., and DeMeo, S., 1970, Correlation of human skin reactivity with lymphocyte transformation induced by mycobacterial antigens and histoplasmin, Am. Rev. Resp. Dis. 101: 67–73.
Chilgren, R. A., Meuwissen, H. J., Quie, P. G., Good, R. A., and Hong, R., 1969, The cellular immune defect in chronic mucocutaneous candidiasis, Lancet 1: 1286–1288.
Christiansen, A. H., and Svejgaard, E., 1976, Studies of the antigeneic structure of Trichophyton rubrum, Trichophyton mentagrophytus, Microspora canis, and Epidermophyton floccosum by crossed immunoelectrophoresis, Acta Pathol. Microbiol. Scand. Sect. C 84: 337–341.
Clauson, J. E., 1973, Migration inhibitory effect of cell-free supernatants from tuberculin stimulated cultures of human mononuclear leukocytes demonstrated by two-step MIF agarose assay, J. Immunol. 110: 546–551.
Cochrane, A. M. G., Moussouros, A., Thomson, A. D., Eddleston, A. L. W., and Williams, R., 1976, Antibody dependent cell-mediated (K cell) cytotoxicity against isolated hepatocytes in chronic active hepatitis, Lancet 1: 441–444.
Coffey, R. C., Hadden, E. M., and Hadden, J. W., 1977, Evidence for cyclic GMP and calcium mediation of lymphocyte activation by mitogens, J. Immunol. 119: 1387–1894.
Coombs, P. R. A., and Gell, P. G. H., 1975, Classification of allergic reactions responsible for clinical hypersensitivity and disease, In: Clinical Aspects of Immunology ( P. G. H. Gell, P. R. A. Coombs, and P. J. Lachmann, eds.), Blackwell, Oxford.
Coutinho, A., and Möller, G., 1975, Thymus-independent B-cell induction and paralysis, Adv. Immunol. 21: 113–236.
Cox, R. A., and Vivas, J. R., 1977, Spectrum of in vivo and in vitro cell-mediated immune responses in coccidioidomycosis, Cell. Immunol. 31: 130–141.
Crowther, D., Hamilton-Farley, C., and Sewell, R. L., 1969, Lymphoid cellular responses in the blood after immunization in man, J. Exp. Med. 128: 849.
Cunningham-Rundles, S., Hansen, J. A., and Dupont, B., 1976, Lymphocyte transformation in vitro in response to mitogens and antigens, In: Clinical Immunobiology, Vol. III ( F. Bach and R. A. Good, eds.), pp. 151–194, Academic Press, New York.
Cunningham-Rundles, S., Cunningham-Rundles, C., Pollack, M. S., Good, R. A., and Dupont, B., 1978, Response to wheat antigen in in vitro lymphocyte transformation among HLA-B8 positive normal donors, Transplant. Proc. 10: 997–979.
Cunningham-Rundles, S., Cunningham-Rundles, C., Dupont, B., and Good, R. A., 1980, Zinc-induced activation of human B lymphocytes, Clin. Immunol. Immunopathol. 16: 115–122.
Curtis, J. E., Hersh, E. M., Harris, J. E., McBride, C., and Freireich, E. J., 1970, The human primary immune response to keyhold limpet haemocyanin: Interrelationships of delayed hypersensitivity, antibody response and in vitro blast transformation, Clin. Exp. Immunol. 6: 473–491.
David, J. R., Al-Askari, S., Lawrence, H. S., and Thomas, L., 1964, Delayed hypersensitivity in vitro. 1. The specificity of inhibition of cell migration by antigens, J. Immunol. 93: 264–273.
Davie, J. M., and and Paul, W. E., 1973, Immunological maturation: Preferential proliferation of high affinity precursor cells, J. Exp. Med. 137: 201–204.
Dean, J. H., Silva, J. S., McCoye, J. L., Leonard, L. M., Cannon, G. B., and Herberman, R. B., 1975, Functional activities of rosette-separated human peripheral blood leukocytes, J. Immunol. 115 (5): 1449–1455.
Delfraissy, J. F., Galanaud, P., Dormont, J., and Wallon, C., 1977, Primary in vitro response from human peripheral blood lymphocytes, J. Immunol. 118: 630–635.
Delfraissy, J. F., Galanaud, P., Wallon, Ch., Pascal, Cl., Dormont, J., and Wallon, C., 1978, Primary in vitro antibody response of human peripheral blood lymphocytes: Role of phagocytic mononuclear cells, J. Immunol. 120: 1283–1288.
DeVries, J. E., Caviles, A. P., Jr., Bont, W. S., and Mendelsohn, J., 1979, The role of monocytes in human lymphocyte activation by mitogens, J. Immunol. 122: 1099–1107.
Diamond, R. D., and Bennett, J. E., 1973, Disseminated cryptococcoses in man. Decreased lymphocyte transformation in response to Cryptococcus neoformans, J. Infect. Dis. 127: 694–697.
Dickler, H. B., and Kunkel, H. G., 1972, Interaction of aggregated gamma globulin with B lymphocytes, J. Exp. Med. 136: 191–196.
Diener, E., Kraft, N., and Armstrong, W. D., 1973, Antigen recognition. 1. Immunological significance of antigen-binding cells, Cell. Immunol. 6: 80–86.
Dosch, H. M., and Gelfand, E. W., 1976, In vitro induction and measurement of hemolytic plaque forming cells in man, J. Immunol. Methods 11: 107–116.
Douglas S D Hoffman, D. F., Borjeson, J., and Chessin, L. N., 1967, Studies on human peripheral blood lymphocytes in vitro. III. Fine structural features of lymphocyte transformation by pokeweed mitogen, J. Immunol. 98: 17–30.
Dumonde, D. C., Wolstencroft, R. A., Panayii, G. S., Matthew, M., Morley, J., and Howson, W. T., 1969, “Lymphokines”: Non antibody mediators of cellular immunity generated by lymphocyte activation, Nature (London) 224: 38–42.
Dumonde, D. C., Page, D. A., Matthew, M., and Wolstencroft, R. A., 1972, Preparation and partial purification of guinea pig lymphocyte activation products, Clin. Exp. Immunol. 10: 25–48.
Dutton, B. W., Falkoff, R., Hirst, J. A., Hoffman, M., Kappler, J. W., Keffman, J. R., Lesley, J. F., and Vann, D., 1971, Is there evidence for a nonantigenspecific diffusible chemical mediator from thymus-derived cells in the initiation of the immune response?, In: Progress in Immunology ( B. Amos, ed.), pp. 355–368, Academic Press, New York.
Dwyer, J. W., and Mackay, I. R., 1970, Antigen-binding lymphocytes in human blood, Lancet 1: 164.
Eckhardt, R., Kloos, P., Dierich, M. P., and Meyer Zum Buschen felde, K. H., 1977, Kymphocytes (killer cells) in Crohn’s disease and acute virus B-hepatitis, Gut 18: 1010–1016.
Edelman, G. M., Cunningham, B. A., Roeke, G. N., 1972, The covalent and three dimensional structure of concanavalin A, Proc. Natl. Acad. Sci. USA 69: 2580–2584.
Ehrenreich, B. A., and Cohn, Z. A., 1967, The uptake and digestion of iodinated human serum albumin by macrophages in vitro, J. Exp. Med. 126: 941–958.
Eisen, S. A., Wedner, H. J., and Parker, C. W., 1972, Isolation of pure human peripheral blood T lymphocytes using nylon wool columns, Immunol. Commun. 6: 571–577.
Engleman, E. G., McMichael, A. J., Batey, M. E., and McDevitt, H. O., 1978a, A suppressor T cell of the mixed lymphocyte reaction in man specific for the stimulating alloantigen: Evidence that identity at HLA-D between suppressor and responder is required for suppression, J. Exp. Med. 147: 137–146.
Engleman, E. G., McMichael, A. J., and McDevitt, H. O., 19786, Suppression of the mixed lymphocyte reaction in man by a soluble T-cell factor, J. Exp. Med. 147: 1037–1043.
Erb, P., Feldman, M., and Hogg, N., 1976, Role of macrophages in the generation of T helper cells. IV. Nature of genetically related factor derived from macrophages incubated with soluble antigens, Eur. J. Immunol. 6 (5): 365–372.
Evans, R. L., Breard, J. M., Lazarus, H., Schlossman, S. F., and Chess, L., 1977, Detection, isolation, and functional characterization of two human T-cell subclasses bearing unique differentiation antigens, J. Exp. Med. 145: 221–233.
Farrar, J. J. and Fuller-Bonar, J., 1976, The xenogeneic effect. II. Requirement for unactivated murine T cells during restoration of immune responsiveness with xenogeneic reconstitution factor, J. Immunol. 117: 274–282.
Fauci, A. S., and Pratt, K. R., 1976, Activation of human B lymphocytes. 1. Direct plaque-forming cell assay for the measurement of polyclonal activation and antigenic stimulation of human B lymphocytes, J. Exp. Med. 144: 647–684.
Fauci, A. S., Haynes, B. F., and Whalen, G., 1978, Multiple subpopulations of mononuclear cells regulating human B cell function, In: Cell Biology and Immunology of Leukocyte Function ( M. Quastel, ed.), pp. 485–488, Elsevier North-Holland, Amsterdam.
Feldman, M., 1972, Cell interactions in the immune response in vitro. V. Specific collaboration via complexes of antigen and thymus-derived cell immunoglobulin, J. Exp. Med. 136: 737–760.
Feldman, M., 1974, T cell suppression in vitro. I. Role in regulation of antibody responses. Eur. J. Immunol. 4: 660–666.
Feldman, M., Howard, J. G., and Desaymard, C., 1975, Role of antigen structure in the discrimination between tolerance and immunity by B cells, Transplant Rev. 23: 78–97.
Fernandez, C., and Möller, G., 1977, The immune response against two epitopes on the same thymus-independent polysaccharide carrier. II. Enhanced anti-hapten responses by injection of the unconjugated carrier, Immunology 33: 331–337.
Fink, P. C., Shedel, I., Peter, H. H., and Deicher, H., 1977, Inhibition of spontaneous and antibody-dependent cellular cytotoxicity by sera and isolated antiglobulin preparations from rheumatoid arthritis patients, Scand. J. Immmunol. 6: 173–183.
Fisher, D. B., and Mueller, G. C., 1971, Studies on the mechanism by which phytohemagglutinin rapidly stimulates phospholipid metabolism of human lymphocytes, Biochem. Biophys. Acta 248: 434–448.
Fodge, D. W., and Rubin, H., 1973, Activation of phosphofrucokinase by stimulants of cell multiplication, Nature (London) New Biol. 246: 181–183.
Forman, J. and Möller, G., 1973, The effector cell in antibody-induced cell-mediated immunity, Transplant. Rev. 17: 108–149.
Frenkel, J. K., 1967, Adoptive immunity to intracellular infection, J. Immunol. 98: 1309–1319.
Friedman, S. M., Breard, J. M., and Chess, L., 1976, Triggering of human peripheral blood B cells: Poly-clonal induction and modulation of an in vitro PFC response, J. Immunol. 117: 2021–2028.
Freland, S. S., and Natvig, J. B., 1973, Identification of three different human lymphocyte populations by surface markers, Transplant. Rev. 16: 114–162.
Geha, R. S., Schneeberger, E., Rosen, F. S., and Merler, E., 1973, Interaction of human thymus-derived and non thymus-derived lymphocytes in vitro: Induction of proliferation and antibody synthesis in B lymphocytes by a soluble factor released from antigen-stimulated T lymphocytes, J. Exp. Med. 137: 1230–1247.
Germain, R. N., and Benacerraf, X. Y., 1978, Antigen-specific T cell-mediated suppression. III. Induction of antigen specific suppressor T cells (Ts2) in L-glutamic acid60-L-alanine30-L-tyrosine10k (GAT) responder mice by nonresponder derived GAT-suppressor factor (GAT-TsF), J. Immunol. 121: 608–612.
Gershon, R. K., 1974, Cell control of antibody production, Contemp. Top. Immunobiol. 3: 1–35.
Gershon, R., and Kondo, K., 1970, Cell interactions in the induction of tolerance: The role of thymic lymphocytes, Immunology 18: 723–737.
Gery, I., Eyel, O., and Benezra, D., 1970, The relationship between lymphocyte transformation and the immune response. III. Kinetics of production of antibody-forming cells and transforming cells, Immunology 19: 97–104.
Gery, I., Gershon, R. K., and Unanue, E. R., 1972, Potentiation of the T-lymphocyte response to mitogens, J. Exp. Med. 136: 128–142.
Godai, T., Myklestad, B., Samuel, D. R., and Myrvang, B., 1971, Characterization of the cellular immune defect in lepromatous leprosy: A specific lack of circulating mycobacterium leprae-reactive lymphocytes, Clin. Exp. Immunol. 9: 821–831.
Gorczynski, R.M., and Feldman, M., 1975, B cell heterogeneity and difference in the size of B lymphocytes responding to T dependent and T independent antigens, Cell. Immunol. 18: 88–97.
Gorczynski, R. M., Miller, R. C., and Phillips, R. A., 1973, Reconstitution of T cell depleted spleen cell populations by factors derived from T cells, I. Conditions for the production of active T cell supernatants, J. Immunol. 110: 968–983.
Gormus, B. J., and Kaplan, M. E., 1976, Differences in human lymphocyte receptors for heat-aggregated and antigen-complexed IgG, Fed. Proc. 35: 856.
Gorski, A. J., Dupont, B., Hansen, J. A., and Good, R. A., 1975, Leukocyte migration inhibitory factor (LMIF) induced by concanavalin A: A standardized microassay for production in vitro, Proc. Natl. Acad. Sci. USA 72: 3197–3200.
Gorski, A. J., Dupont, B., Hansen, J. A., Safai, B., Pahwa, S., and Good, R. A., 1977a, Human immunodeficiency disease: Impairment of cellular interactions leading to abnormal mediator production in mixed lymphocyte culture reaction, J. Immunol. 118: 858–862.
Gorski, A. J., Cunningham-Rundles, S., Dupont, B., Hansen, J. A., Pahwa, S., Gorska, R., and Good, R. A., 1977b, Unilateral LMIF production in MLC reaction as a measure of immunocompetence in immunodeficiency disease, In: Regulatory Mechanisms in Lymphocyte Activation (D. O. Lucas, ed.), pp. 686–688, Academic Press, New York.
Graziano, K. D., Ruckdeschel, J. C., and Mardiney, B. R., 1975, Cell-associated immunity to measles (rubeola): The demonstration of in vitro lymphocyte tritiated thymidine incorporation in response to measles complement fixation antigen, Cell. Immunol. 15: 347–359.
Greaves, M. F., and Bauminger, S., 1972, Activation of T and B lymphocytes by insoluble phytomitogens, Nature (London) New Biol. 235: 67–70.
Greaves, M. F., and Brown, 1973, A human B lymphocyte specific antigen, Nature (London) New Biol. 246: 116–119.
Greaves, M., Janossy, G., and Doenhoff, M., 1974, Selective triggering of human T and B lymphocytes in vitro by polyclonal mitogens, J. Exp. Med. 140: 1–18.
Gronowicz, E., and Coutinho, A., 1976, Heterogeneity of B cells: Direct evidence of selective triggering of distinct subpopulations by polyclonal activators, Scand. J. Immunol. 5: 55–67.
Gupta, S., and Good, R. A., 1978, Subpopulations of human T lymphocytes. III. Distribution and quantitation in peripheral blood, cord blood, tonsils, bone marrow, thymus, lymph nodes, and spleens, Cell Immunol. 36: 76–83.
Gupta, S., Fernandes, G., Nair, M., and Good, R. A., 1978a, Spontaneous and antibody-dependent cell-mediated cytotoxicity by human T cell subpopulations, Proc. Natl. Acad. Sci. USA 75: 5137–5141.
Gupta, S., Safai, B., and Good, R. A., 1978b, Rosette formation with mouse erythrocytes. VI. T, B and third population lymphoid cells in mycosis fungoides and effect of leukopheresis, Am. J. Hematol. 4: 133–140.
Ha, T. Y., and Waksman, B. H., 1973, Role of the thymus in tolerance. X. “Suppressor” activity of antigen-stimulated rat thymocytes transferred to normal recipients, J. Immunol. 110: 1290–1299.
Haber, J., Rosenau, W., and Goldberg, M., 1972, Separate factors in PHA induced lymphotoxin interferon and nucleic acid synthesis, Nature (London) 238: 60–62.
Hadden, J. W., and Englard, A., 1977, Molecular aspects of macrophage activation and proliferation, Immunopharmacology 5: 87–99.
Hadden, J. W., Hadden, E. M., Haddox, M. K., and Goldberg, N. D., 1972, Guanosine 31:S1 cyclic mono-phosphate: A possible mediator of mitogenic influences in lymphocytes, Proc. Natl. Acad. Sci. USA 69: 3024–3027.
Hadden, J. W., Hadden, E. M., Johnson, C. D., and Johnson, E. M., 1975, Cyclic nucleotides in lymphocyte function and metabolism, In: Lymphocytes and Their Interactions ( R.C. Williams, ed.), pp. 27–55, Raven Press, New York.
Hadden, J. W., Hadden, E. M., Sadlik, J. R., and Coffey, B. G., 1976, Effects of concanavalin A and a succinylated derivative on lymphocyte proliferation and cyclic nucleotide levels, Proc. Natl. Acad. Sci. USA 73 (5): 1717–1721.
Hadden, J. W., Sadlik, J. R., and Hadden, E. M., 1978, The inductin of macrophage proliferation in vitro by a lymphocyte-produced factor, J. Immunol. 121: 231–238.
Han, T., Minowada, J., Subramanian, S., and Sinks, L. F., 1976, Human thymus cells: Blastogenic response to mitogens, antigens and allogeneic cells, Immunology 31: 516–525.
Hedfors, E., Holm, G., and Ohnell, B., 1976, Variations of blood lymphocytes during work studies by cell surface markers. DNA synthesis and cytotoxicity, Clin. Exp. immunol. 24: 328–335.
Hellström, K. E., and Hellström, I., 1974, Lymphocyte mediated cytotoxicity and blocking serum activity to tumor antigens, Adv. Immunol. 18: 209–277.
Herberman, R. S., and Oldham, R. K., 1975, Problems associated with study of cell-mediated immunity to human tumors by microcytotoxicity assays. J. Natl. Cancer Inst. 55: 749–753.
Herzenberg, L. A., Chan, E. L., Revitch, M. M., Riblet, R. J., and Herzenberg, L. A., 1973, Active suppression of immunoglobulin allotype synthesis. III. Identificatin of T cells as responsible for suppression by cells from spleen, thymus, lymph node and bone marrow, J. Exp. Med. 137: 1311–1323.
Hirschberg, H., and Bergh, O. J., 1978, Defective T lymphocyte-macrophage interaction in leprosy, In: Cell Biology and Immunology of Leukocyte Function ( M. Quastel, ed.), pp. 893–899, Ben Gurion University, Israel.
Hirst, J. A., and Dutton, R. V., 1970, Cell components in the immune response. III. Neonatal thymectomy restoration in culture, Cell Immunol. 1: 190–195.
Hoffman, M. K., 1980, Sensitization of human peripheral blood lymphocytes to red cell antigens in vitro, Proc. Natl. Acad. Sci. USA (in press).
Hoffman, M. K., Schmidt, D., and Oettgen, H. F., 1973, Production of antibody to sheep red blood cells by human tonsil cells in vitro, Nature (London) 243: 408–409.
Hoiby, N., Andersen, V., and Bendison, G., 1975, Pseudomonas aeruginosa infection in cystic fibrosis: Humoral and cellular immune responses against Pseudomonas aeruginosa, Acta Pathol. Microbiol. Scand. Sect C 83: 459–488.
Holm, G., and Perlmann, P., 1967, Cytotoxic potential of stimulated human lymphocytes, J. Exp. Med. 125: 721.
Horton, J. E., Oppenheim, J. J., Mergenhagen, S. E., and Raisz, L. C., 1974, Macrophage-lymphocyte synergy in the production of osteoclast activating factor, J. Immunol. 113: 1278–1287.
Horwitz, D. A., and Garrett, M. A., 1977, Distinctive functional properties of human blood L lymphocytes: A comparison with T lymphocytes, B lymphocytes and monocytes, J. Immunol. 118: 1712–1721.
Horwitz, D. A., Garrett, M. A., and Craig, A. H., 1977, Serum effects on mitogenic reactivity in subjects with systemic lupus erythematosus, rheumatoid arthritis, and scleroderma: Technical considerations and lack of correlation with antilymophocyte antibodies, Clin. Exp. Immunol. 27: 100–110.
Humphreys, R. E., McCune, J. M., Chess, L., Herrman, H. C., Malenka, D. J., Mann, D. L., Parham, P., Schlossman, S. F., and Strominger, J. L., 1976, Isolation and immunologic characterization of a human, Blymphocyte-specific cell surface antigen, J. Exp. Med. 144: 98–112.
Hungerford, D. A., Donnelly, A. J., Nowell, P. C., and Beck, S., 1959, The chromosome constitution of a human phenotype intersex, Am. J. Hum. Genet. 11: 215–236.
Inman, D. R., and Cooper, F. H., 1963, Electron microscopy of human lymphocytes stimulated by PHA, J. Cell Biol. 19: 441–452.
Janossy, G., De La Concha, E. G., Waxdal, M. J., and Platts-Mills, T., 1976, The effects of purified mitogenic proteins (Pa-1 and Pa-2) from pokeweed on human T and B lymphocytes in vitro, Clin. Exp. Immunol. 26: 108–117.
Janossy, G., Gomez de la Concha, E., Luquetti, A., Snajdr, M. J., Waxdal, M. J., and Platts-Mills, 1977, T-cell regulation of immunoglobulin synthesis and proliferation in pokeweed (Pa-2)-stimulated human lymphocyte cultures, Scand. J. Immunol. 6: 110–123.
Jennings, J. J., and Rittenberg, M. B., 1976, Evidence for separate subpopulations of B cells responding to T-independent and T-dependent immunogens, J. Immunol. 117: 1749–1752.
Jondal, M., 1974a, Surface markers on human B and T lymphocytes. III. A marker for lymphoid adherence, Scand. J. Immunol. 3: 269–276.
Jondal, M., 1974b, Surface markers on human B and T lymphocytes. IV. Distribution of surface markers on resting and blast-transformed lymphocytes, Scand. J. Immunol. 3: 739–747.
Jondal, M., and Pross, H. T., 1975, Surface markers on human B and T lymphocytes. VI. Cytotoxicity against cell lines as functional markers for lymphocyte subpopulations, Int. J. Cancer 15: 596–605.
Jones, E. A., Goodfellow, P. N., Bodmer, J. G., and Bodmer, W. F., 1975, Serological identification of HLA-linked human “Ia-type” antigens, Nature (London) 256: 650.
Jones, G., 1973, Release of surface receptor from lymphocytes, J. Immunol. 110: 1526–1531.
Kall, M. A., and Koren, H. S., 1978, Heterogeneity of human natural killer cell populations, Cell Immunol. 40: 58–68.
Kall, M. A., Hellstrom, I., and Hellstrom, K. E., 1975, Different response of lymphoid cells from tumor-bearing as compared to tumor-immunized mice when sensitized to tumor specific antigens in vitro, Proc. Natl. Acad. Sci. USA 72: 5086–5089.
Kapp. J. A., Pierce, C. W., Dela Croix, F., and Benacerraf, B., 1976, Immunosuppressive factors(s) extracted from lymphoid cells of non-responder mice primed with L-glutamic acid 60-L-alanine 30-L tyrosine 10 (GAT), J. Immunol. 116 (2): 305–309.
Kay, H. D., Bonnard, G. D., and Herberman, R. B., 1979, Evaluation of the role of IgG antibodies in human natural cell mediated cytotoxicity against the myeloid cell line K 562, J. Immunol. 122: 675–685.
Kay, J. E., 1969, The role of the stimulant in the activation of lymphocytes by PHA, Exp. Cell Res. 58: 185–187.
Kay, J. E., Oppenheim, J. J., and Mergenhagen, S. E., 1971, Specificity of inhibition of lymphocyte activation by anti-PHA antisera, Proc. Soc. Exp. Biol. Med. 138: 112–117.
Keightly, R. G., Cooper, M. D., and Lawton, A. R., 1976, The T cell dependence of B cell differentiation induced by pokeweed mitogen in vitro, J. Immunol. 117: 1538–1544.
Kilburn, D. G., Smith, J. B., and Gorczynski, R. M., 1974, Nonspecific suppression of T lymphocyte response in mice bearing progressively growing tumors, Eur. J. Immunol. 4: 784–788.
Kincade, P. W., and Ralph, P., 1976, Regulation of clonal B lymphocyte proliferation by anti-immunoglobulin or anti-Ia antibodies, Cold Spring Harbor Symp. Quant. Biol. 41: 245–250.
Kirkpatrick, C. H., 1971, Chronic mucocutaneous candidiasis: Model-building in cellular immunity, Ann. Intern. Med. 74: 955–978.
Kishimoto, T., Ralph, P., and Good, R. A., 1977, Stimulation of a human B-lymphocyte line by anti-immunoglobulin and its concanavalin A-induced suppression by a T-cell line, Clin. Exp. Immunol. 30: 62–69.
Koren, H. S., and Kall, M. A., 1978, Natural killing (NK) and antibody dependent cellular cytotoxicity (ADCC) in humans are mediated by distinct mechanisms, In: Proceedings of the 12th Leukocyte Culture Conference (M. Quastel, ed.), Abstr. No. 158, Ben Gurion University, Israel.
Koren, H. S., Amos, D. B., and Buckley, R. H., 1978, Natural killing in immunodeficient patients, J. Immunol. 120: 796–799.
Krammer, P. H., and Pernis, B., 1976, The effect of antiimmunoglobulin antibodies of Fc rosettes, Scand. J. Immunol. 5 (3): 199–204.
Kreger, A. S., Cuppari, O., and Toranta, A., 1972, Isolation by electrofocusing of two lymphocyte mito-gens produced by Staph. aureus, Infect. Immun. 5: 723–727.
Kreth, H. W., Thiessen, G., and Deicher, 1970, The effect of antigen given intravenously on specific antigen-sensitive lymphocytes of peripheral blood in man, Clin. Exp. Immunol. 7: 109–114.
Krishnaraj, R., and Talwar, G. P., 1973, Role of cAMP in mitogen induced transformation of human peripheral lymphocytes, J. Immunol. 111: 1010–1017.
Labowskie, R. J., Edelman, R., Rustigan, R., and Bellanti, J. A., 1974, Studies of cell-mediated immunity to measles virus by in vitro lymphocyte-mediated cytotoxicity, J. Infect. Dis. 129: 233–239.
Lawton, A. R., and Cooper, M. D., 1974, Modification of B lymphocyte differentiation by anti-immunoglobulin, In: Contemporary Topics in Immunobiology ( M. D. Cooper and N. I. Warner, eds.), pp. 193–225, Plenum, New York.
Lazda, V. A., and Baram, P., 1974, Participation of different cell populations in antigen-and mitogen-induced lymphocyte proliferation: Evidence that blastogenic factor-sensitive lymphocytes are inactivated by 5-bomo-2’-deoxyuridine, J. Immunol. 112: 1705–1717.
Levis, W. R., and Robbins, J. H., 1970, Function of glass-adherent cells in human mixed lymphocyte cultures, Transplantation 9: 515–518.
Lewi, S., 1970, Allergic cutanée tuberculinique et transformation blastique des lymphocytes cultivée in vitro en presence de tuberculine, Ann. Inst. Pasteur 119: 630–645.
Lindahl-Kiessling, K., 1972, Mechanism of PHA action. V. PHA compared with Con A, Exp. Cell Res. 70: 17–26.
Lindahl-Kiessling, K., and Mattson, A., 1971, Mechanism of PHA action. IV. Effect of some metabolic inhibitors on binding of PHA to lymphocytes and the stimulating potential of PHA-treated cells, Exp. Cell Res. 55: 85–87.
Lindahl-Kiessling, K., and Peterson, R. D. A., 1969, The mechanism of phytohemagglutinin (PHA) action. II. The effect of certain enzymes and sugars, Exp. Cell Res. 55: 81–84.
Ling, N. R. and Kay, J. E., 1975, Lymphocyte Stimulation, p. 179, North-Holland, Amsterdam.
Lis, H., and Sharon, N., 1973, The biochemistry of plant lectins, Annu. Rev. Biochem. 42: 541–574.
Lodmell, D. L., Akira, N., Hagashi, K., and Notkins, A. L., 1973, Prevention of cell-to-cell spread of herpes simplex virus by leukocytes, J. Exp. Med. 137: 706.
Lohrman, H. P., Novikows, L., and Grau, R. G., 1974, Cellular interactions in the proliferative response of human T and B lymphocytes to phytomitogens and allogeneic lymphocytes, J. Exp. Med. 129: 1553.
London, J., Berrih, S., and Bach, J. F., 1978, Peanut agglutinin, I. A new tool for studying T Lymphocyte subpopulations, J. Immunol. 121: 438–4. 43.
Lopez, C., and O’Reilly, R. J., 1977, Cell-mediated immune response in recurrent herpes virus infections. 1. Lymphocyte proliferation assay, J. Immunol. 118: 895–902.
Lopez, C., Simmons, R. L., Park, B. H., Najarian, J. S., and Good, R. A., 1974, Cell-mediated and humoral immune responses of renal transplant recipients with cytomegalovirus infections, Clin. Exp. Immunol. 16: 565–573.
Lozzia, B. B., Machado, E. A., and Chernoff, A. I., 1969, Functional and cellular alterations produced by PHA. III. Hematologic findings in mice receiving PHA, Acta Ha em a tol. 41: 349–358.
Lyet, J. P., Varga, A. L., and Normansell, D. E., 1977, Subpopulations of human peripheral blood lymphocytes, Cell Immunol. 33: 191–202.
Mackaness, G. B., 1999, The influence of immunologically committed lymphoid cells on macrophage activity in vivo, J. Exp. Med. 129: 973–992.
MacLennan, I. C. M., and Harding, B., 1970, Failure of certain cytoxic lymphocytes to respond mitotically to phytohemagglutinin, Nature (London) 227: 1246–1248.
Mann, D. L., and Falk, R. E., 1973, Production of antibody by human peripheral lymphocytes after allogeneic stimulation, In: Proceedings of the 7th Leukocyte Culture Conference ( F. Daquillard, ed.), pp. 39–48, Academic Press, New York.
Mann, D. L., Abelson, L., Harris, S., and Amos, B., 1975, Detection of antigens specific for B-lymphoid cultured cell lines with human alloantisera, J. Exp. Med. 142: 84–89.
Marmor, M. F. and Barnett, E. V., 1968, Cutaneous anergy without systemic disease: A syndrome associated with mucocutaneous fungal infection, Am. J. Med. 44: 979–989.
Matsoniotis, N. S., and Tsenghi, C. J., 1964, Mitosis in leukocyte cultures, Lancet 1: 989.
McConnell, L., and Hurd, C. M., 1976, Lymphocyte receptors. II. Receptors for rabbit IgM on human lymphocytes, Immunology 30: 835–839.
McFarland, W., and Heilman, D. H., 1966, Comparison of lymphocyte transformation and intradermal reactions to tuberculins, Am. Rev. Respir. Dis. 93: 742.
McFarland, W., Heilman, D. H., and Moorehead, J. F., 1966, Functional anatomy of the lymphocyte in immunological reactions in vitro, J. Exp. Med. 124: 851–858.
McMichael, A. J., and Sasazukis, T., 1977, A suppressor T cell in the human mixed lymphocyte reaction, J. Exp. Med. 146: 368–379.
Mendelsohn, J., Skinner, A., and Kornfeld, S., 1971, The rapid induction by phytohemagglutinin of increased a-amino isobutyric acid uptake by lymphocytes, J. Clin. Invest. 50: 818–826.
Moeller, G. (ed.), 1973, T and B lymphocytes in humans, Transplant Rev. 16:818–826.
Morse, J. H., 1968, Immunological studies of PHA. I. Reaction between PHA and normal sera, Immunology 14: 713–724.
Moretta, L., Ferrarini, M., Durante, M. I., and Mingari, M. C., 1975, Expression of a receptor for IgM by human T cells in vitro, Eur. J. Immunol. 5: 565–569.
Mosier, D. E., 1967, A requirement for two cell types in antibody formation in vitro, Science 158: 1573–1575.
Muchmore, A. V., Decker, J. M., and Blaese, R. M., 1977, Spontaneous cytotoxicity of human peripheral mononuclear cells toward red blood cell targets in vitro. 1. Characterization of the killer cell, J. Immunol. 119: 1680–1685.
Neiman, P. E., and MacDonnell, 1976, Studies on the mechanism of increased protein synthesis in human PHA stimulated lymphocytes, In: Proceedings of the 5th Leukocyte Culture Conference (J. Harris, ed.), pp. 61–72, Academic Press, New York.
Nelson, D. L., Bundy, B. M., West, T. D., and Strober, W., 1976, The effector cells in human peripheral blood mediating mitogen-induced cellular cytotoxicity (MICC) and antibody-dependent cellular cytotoxicity (ADCC), Cell. Immunol 23: 89–98.
Nelson, D. S., 1972, In: Macrophages and Cellular Immunity (A. Laskin and H. Lechervalier, eds.), pp. 45–76, Chemical Rubber Co., New Jersey.
Newberry, W. M., Jr., Chandler, J. W., Jr., and Chin, T. D. Y., 1968, Immunology of the mycosis. I. Depressed lymphocyte transformation in chronic histoplasmosis, J. Immunol. 100: 436–443.
Nilsson, B. S., 1972, The response of lymphocytes from tuberculin positive or negative humans to various doses of PPD-tuberculin in vitro, Cell. Immunol. 3: 493–500.
Ninneman, J. L., 1978, Melanoma-associated immunosuppression through B cell activation of suppressor T cells, J. Immunol. 120: 1573–1579.
North, R. J., 1973, Importance of thymus-derived lymphocytes in cell-mediated immunity to infection, Cell Immunol. 7: 166–176.
Novogrodsky, A., and Katchalsi, E., 1971, Induction of lymphocyte transformation by periodate, Fed. Eur. Biochem. Soc. Lett. 12: 297–300.
Novogrodsky, A., and Katchalsi, E., 1973, Transformation of neuraminidase-treated lymphocytes by soybean agglutinin, Proc. Natl. Acad. Sci USA 70: 2515–2518.
Novogrodsky, A., Stenzel, K. H., and Rubin, A., 1977, Stimulation of human peripheral blood lymphocytes by periodate, galactose oxidase, soybean agglutinin, and peanut agglutinin: Differential effects of adherent cells, J. Immunol. 118: 852–857.
Oehler, J. R., Herberman, B. B., Campbell, D. A., and Djeu, J. Y., 1977, Inhibition of rat mixed lymphocyte cultures by suppressor macrophages, Cell Immunol. 29: 238–247.
Ono, A., Amos, D. B., and Koren, H. S., 1977, Selective cellular natural killing against human leukemic T cells and thymus, Nature (London) 266: 546–547.
Oppenheim, J. J., Leventhal, B. G., Hersh, E. M., 1968, The transformation of column purified lymphocytes with nonspecific and specific antigenic stimuli, J. Immuno1. 101: 262–267.
O’Reilly, R. J., Chibarro, A., Anger, E., and Lopez, C., 1977, Cell mediated immune response in patients with recurrent Herpes simplex infections. II. Infection-associated deficiency of lymphokine production in patients with recurrent herpes labialies or herpes progenitalis, J. Immunol. 118: 1095–1102.
Ortaldo, J. R., Bonnard, G. D., and Herberman, R. S., 1977, Cytotoxic reactivity of lymphocytes cultured in vitro, J. Immunol. 119: 1351–1357.
Ottesen, E. A., Weller, P. F., and Heck, L., 1977, Specific cellular immune unresponsiveness in human filariasis, Immunology, 33: 413–421.
Owen, F. L., Ju, S. T., and Nisonoff, A., 1977, Presence on idiotype-specific suppresor T cells of receptors that interact with molecules bearing the idiotype, J. Exp. Med. 145: 1559–1566.
Pape, G. R., Troye, M., and Perlmann, P., 1977, Characterization of cytolytic effector cells in peripheral blood of healthy individuals and cancer patients. II. Cytotoxicity to allogeneic or autochtonous tumor cells in tissue cultures, J. Immunol. 118: 1925–1930.
Papermaster, B. W., Holterman, O. A., Klein, E., Parmett, S., Dobkin, D., Laudico, R., and Djerassi, I., 1976, Lymphokine properties of a lymphoid cultured cell supernatant fraction active in promoting tumor regression, Clin. Immunol. Immunopathol. 5 (1): 48–59.
Parker, J. W., and Lukes, R. J., 1971, “Spontaneous” lymphocyte transformation following Hong Kong flu, In: Proceedings of the IVth Leukocyte Culture Conference (O. R. McIntyre, ed.), p. 281, Appleton-CenturyCrofts, New York.
Parrott, D. M. V., Good, R. A., O’Neill, G. J., and Gupta, S., 1978, Heterogeneity of locomotion in human T cell subsets (chemotaxis/receptors for immunoglobulin/ lymphocyte subpopulations) Proc. Natl. Acad. Sci. USA 75: 2392–2395.
Pearmain, G., Lycette, R. R., and Fitzgerald, P. H., 1963, Tuberculin induced mitosis in peripheral blood leukocytes, Lancet 1: 637.
Perlman, P., Biberfeld, P., Larsson, A., Perlman, H., and Wahlin, B., 1975, In: Membrane Receptors of Lymphocytes: Inserm Symposium I (M. Seligman, J. L. Preud’homme, and F. M. Kourilsky, eds.), p. 161, American Elsevier, New York.
Perlman, R., and Holm, C., 1969, Cytotoxic effects of lymphoid cells in vitro, Adv. Immunol. 11: 117–193.
Perlmann, P., Perlmann, H., and Wigzell, H., 1972, Lymphocyte mediated cytotoxicity in vitro. Induction and inhibition by humoral antibody and nature of effector cells, Transplant. Rev. 13: 91–114.
Pernis, B., Forni, L., and Amante, L., 1970, Immunoglobulin spots on the surface of rabbit lymphocytes, J. Exp. Med. 132: 1001–1018.
Peter, H. H., Eife, R. F., and Kalden, J. R., 1976, Spontaneous cytotoxicity (SCMC) of normal human lymphocytes against a human melanoma cell line. A phenomenon due to a lymphotoxin-like mediator, J. Immunol. 116: 342–348.
Phillips, B., and Roitt, I. M., 1973, Evidence for transformation of human B lymphocytes by PHA, Nature (London) New Biol. 241: 254–256.
Plate, J. M., and Amos, B., 1971a, Lymphocyte stimulation by a glycopeptide isolated from Streptococcus pyogenes C203S. 1. Isolation and partial purification, Cell. Immunol. 1: 476–487.
Plate, J. M., and Amos, B., 1971b Lymphocyte stimulation by a glycopeptide isolated from Streptococcus pyogenes C203S. II. Kinetics of the response, Cell. Immunol. 1: 488–499.
Playfair, J. H. C., and Purves, E. C., 1971, Separate thymus dependent and thymus independent antibody forming cell precursors, Nature (London) New Biol. 231: 149–151.
Pollack, S. B., and Emmons, S. L., 1979, Inhibition of human killer cells by autologous lymphocytes, J. Immunol. 122: 718–722.
Polliack, A., Lampden, N., Clarkson, B. D., de Harven, E., Bentwick, Z., and Kunkel, H. G., 1973, Identification of human B and T lymphocytes by scanning electron microscopy, J. Exp. Med. 138: 607–624.
Powell, A. E., and Leon, M. A., 1970, Reversible interaction of human lymphocytes with the mitogen Con A, Exp. Cell Res. 62: 315–325.
Pross, H. F., Baines, M. G., Jondal, M., 1977, Spontaneous human lymphocyte mediated cytotoxicity against tumor target cells. II. Is the complement receptor necessarily present on the killer cells? Int. J. Cancer 70: 353–358.
Quastel, M. B., and Kaplan, J. G., 1968, Inhibition by oubain of human lymphocyte transformation induced by phytohemagglutinin in vitro, Nature (London) 219: 198–200.
Quastel, M. R., and Kaplan, J. G., 1970, Early stimulation of potassium uptake in lymphocytes treated with PHA, Exp. Cell Res. 63: 230–233.
Rachelefsky, G. S., Opelz, G., McCay, M. R., Kiuchi, M., Terasaki, P. I., Siegal, S. C., and Stiehm, E. R., 1976, Defective T cell function in atopic dermatitis, J. Allergol. Clin. Immunol. 57: 569–567.
Radcliffe, G. N., and Axelrod, M. A., 1971, Immunological memory in vitro, J. Exp. Med. 133: 846–856.
Raff, M. C., 1970, Role of thymus derived lymphocytes in the secondary humoral immune response in mice, Nature (London) 226: 1257.
Reichert, C. F., Pan, D. M., Matthews, K. P., and Goldstein, I. J., 1973, Lectin induced blast transformation of human lymphocytes, Nature (London) New Biol. 242: 146–148.
Rocklin, R. E., Chilgren, R. A., Hong, R., and David, J. R., 1970, Transfer of cellular hypersensitivity in chronic mucocutaneous candidiasis monitored in vivo and in vitro, Cell. Immunol. 1: 290–299.
Rocklin, B. E., McDermott, R. P., Chess, L., Schlossman, S. F., and David, J. R., 1974, Studies on mediator production by highly purified human T and B lymphocytes, J. Exp. Med. 140: 1303–1316.
Rola-Pleszczynski, M., Hurtado, R. C., Woody, J. N., Sell, K. W., Vincent, M. M., Hensen, S. A., and Bellanti, J. A., 1975, Identification of the cell population involved in viral-specific cell-mediated cytotoxicity in man: Evidence for T cell specificity, J. Immunol. 115: 239–242.
Rosenberg, F. B., McCoy, J. C., Green, S. S., Donnely, F. C., Siwarski, D. F., Levine, P. H., and Herberman, R. B., 1974, Destruction of human lymphoid tissue culture cell lines by human peripheral lymphocytes in b1Crrelease cellular cytotoxicity assays, J. Natl. Cancer Inst. 52: 345–352.
Rosenberg, G. L., Farber, P. A., and Nofkins, A. L., 1972, In vitro stimulation of sensitized lymphocytes by herpes simplex virus and vaccinia virus, Proc. Natl. Acad. Sci. USA 69: 756–760.
Rosenstreich, D. L., Elfenbeen, G., Dougherty, S., and Oppenheim, J. J., 1974, The role of macrophages in proliferation of B and T lymphocytes, Fed. Proc. 33: 744.
Rosenstreich, D. L., Farrar, J. J., and Dougherty, S., 1976, Absolute macrophage dependency of T lymphocyte activation by mitogens, J. Immunol. 116: 131–139.
Rosenthal, A. S., and Shevach, E. M., 1973, The function of macrophages in antigen recognition by guinea pig T-lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes, J. Exp. Med. 138: 1194–1212.
Ruhl, H., Kirchner, H., and Rochert, G., 1971, Kinetics of the Zn+ stimulation of human peripheral lymphocytes in vitro, Proc. Soc. Exp. Med. 137: 1089–1092.
Russell, A. S., and Kaiser, J. T., 1976, Cell-mediated immunity to herpes simplex virus in man, V. Antibody mediated cell-mediated immune lysis of herpes virus-infected target cells, J. Allergy Clin. Immunol. 58: 539–545.
Sakane, T., and Green, I., 1977, Human suppressor T cells induced by concanavalin A: Suppressor T cells belong to distinctive T cell subclasses, J. Immunol. 119: 1169–1176.
Sample, W. F., and Chrétien, P. B., 1971, Thymidine kinetics in human lymphocyte transformation: Determination of optimal labelling conditions, Clin. Exp. Immunol. 9: 419–427.
Santoli, D., Trinchieri, G., Zmijewski, C. M., and Kaprowski, H., 1976, HLA-related control of spontaneous and antibody dependent cell-mediated cytotoxic activity in humans, J. Immunol. 117: 765–770.
Sarkany, I., and Caron, G. A., 1966, Onset of antigen induced lymphocyte transformation following smallpox vaccination, Br. J. Dermatol. 78: 352–354.
Saxon, A., Stevens, R. H., and Ashman, R. F., 1977, Regulation of immunoglobulin production in human peripheral blood leukocytes: Cellular interactions, J. Immunol. 118: 1872–1879.
Schellekens, D. Th. A., and Eijsvoogel, V. P., 1968, Lymphocyte transformation in vitro. 1. Tissue culture conditions and quantitative measurements. Clin. Exp. Immunol. 3: 571–584.
Schendel, D. J., 1980, Cell-mediated lympholysis, In: Clinical Immunobiology, Vol. IV (F. Bach and R. A. Good, eds.), Academic Press, New York, in press.
Schimpl, A., and Wecker, E., 1971, Reconstitution of a thymus-derived immune system by syngeneic and allogeneic thymocytes in vitro, Eur. J. Immunol. 7: 304–306.
Schimpl, A., and Wecker, E., 1975, A third signal in B cell activation given by TRF, Transplant. Rev. 23: 176–188.
Schneider, J., Chin, W., Friou, G. J., Cooper, S. M., Harding, B., Hill, R. L., and Quismorio, F. P., 1975, Reduced antibody dependent cell mediated cytotoxicity in systemic lupus erythematosus, Clin. Exp. Immunol. 20: 187–192.
Schultz, G., Hardman, J. G., Schultz, K., Baird, C. E., and Sutherland, E. W., 1973, The importance of calcium ions for the regulation of guanosine 31:51 cyclic monophosphate levels, Proc. Natl. Acad. Sci. USA 70: 3889–3893.
Seeger, R. C., and Oppenheim, J. J., 1972, Macrophage-bound antigens. II. Comparison of the immunogenicity of antigens bound to macrophages, lymphocytes, thymocytes, and hepatoma cells, J. Immunol. 109: 255–261.
Seeley, J. K., and Golub, S. H., 1978, Studies on cytotoxicity generated in human mixed lymphocyte cultures. I. Time course and target spectrum of several distinct concomitant cytotoxic activities, J. Immunol. 120: 1415–1422.
Shore, S. L., Nahmias, A. J., Starr, S. E., Wood, P. A., and McFarlin, D. E., 1974, Detection of cell-dependent cytotoxic antibody to cells infected with herpes simplex virus, Nature (London) 251: 350.
Shore, S. L., Black, C. M., Melewicz, F. M., Wood, P. A., and Nahmias, A. J., 1976, Antibody dependent cell-mediated cytotoxicity to target cells infected with type 1 and type 2 herpes simplex virus, J. Immunol. 116: 194–201.
Shore, S. L., Melewicz, F. M., and Gordon, D. S., 1977, The mononuclear cell in human blood which mediates antibody-dependent cellular cytotoxicity to virus-infected target cells. I. Identification of the population of effector cells, J. Immunol. 118: 558–566.
Shou, L., Schwartz, S. A., and Good, R. A., 1976, Suppressor cell activity after concanavalin A treatment of lymphocytes from normal donors, J. Exp. Med. 143: 1100–1109.
Simons, M. J., and Fitzgerald, M. G., 1968, Rubella virus and human lymphocytes in culture, Lancet 2: 937–946.
Smith, B. W., Terry, W. D., Buell, D. N., and Sell, K. W., 1973, An antigenic marker for human thymic lymphocytes, J. Immunol. 110: 884–887.
Smith, J. W., and Utz, J. P., 1972, Progressive disseminated histoplasmosis, Ann. Intern. Med. 76: 557–565.
Smith, K. A., Chess, L., and Mardiney, M. R., 1973, The relationship between rubella hemagglutination inhibition antibody (HIA) and rubella induced in vitro lymphocyte tritiated thymidine incorporation, Cell. Immunol. 8: 321–327.
SOborg, M., Andersen, V., and Sorensen, S. F., 1971, Antigen-induced lymphocyte transformation in vitro during primary immunization in man, Acta Pathol. Microbiol. Scand. Sect. B. 79: 495–501.
Sondel, P. M., Jacobsen, M. W., and Bach, F. W., 1975, Preemption of a human cell mediated lympholysis by a suppressive mechanism activated in mixed lymphocyte cultures, J. Exp. Med. 143: 1606–1622.
Sondel, P. M., O’Brien, C., Porter, C., Schlossman, S. F., and Chess, L., 1976, Cell-mediated destruction of human leukemic cells by MHC identical lymphocytes: Requirement for a proliferative trigger in vitro, J. Immunol. 117: 2197–2203.
Sören, J., and Biberfeld, D., 1973, Quantitative studies on RNA accumulation in human PHA-stimulated lymphocytes by PHA, Exp. Cell Res. 79: 359–367.
Sorg, C., and Bloom, B. R., 1973, Products of activated lymphocytes. I. The use of radiolabeling techniques in the characterization and partial purification of the MIF of the guinea pig, J. Exp. Med. 137: 148–170.
Stjernsward, J., Jondal, M., Vanky, F., and Wigzell, H., 1972, Lymphopenia and change in distribution of human B and T lymphocytes in peripheral blood induced by irradiation for mammary carcinoma, Lancet 1: 13–52.
Stobo, J. D., Paul, W. E., and Henney, C. S., 1972. Functional heterogeneity of murine lymphoid cells. I. Responsiveness and surface binding of concanavalin A and phytohemagglutinin, J. Immunol. 108: 1–17.
Stobo, J. D., Paul, S., van Scoy, T. E., and Hermans, P. E., 1976, Suppressor thymus-derived lymphocytes in fungal infections, J. Clin. Invest. 57: 319–328.
Strominger, J. L., Chess, L., Humphreys, R. E., Herrman, H. C., Malenka, D. J., McCune, J. M., Parham, P., Robb, R., Springer, T. A., and Terhorst, C., 1975, Isolation of histocompatibility antigens and of several B-cell specific proteins from cultured human lymphocytes, Histocompat. Test. 50: 719–730.
Sumner, J. B., 1919, The globulins of the jack bean, Canavalia ensiformis, J. Biol. Chem. 37: 137–143.
Tada, T., Taniguchi, M., Tokuhisa, T., and David, C. S., 1976, Antigen-specific suppressive and enhancing T-cell factors determined by distinct loci in the I region of H-2 complex, First International Workshop on Mechanisms of Action and Characterization of Lymphocyte Mediators, Cell. Immunol. 27: 336–337.
Takahashi, T., Ramachandramurthy, P., and Liener, I. E., 1967, Some physical and chemical properties of a phytohemagglutinin isolated from Phaseolus vulgaris, Biochim. Biophys. Acta 133: 127–133.
Takasugi, M., Mickey, M. R., and Terasaki, P. I., 1973, Reactivity of lymphocytes from normal persons on cultured tumor cells, Cancer Res. 33: 2398–2902.
Taniguichi, M., Hayakawa, K., and Tada, T., 1976, Properties of antigen specific suppressive T cell factor in the regulation of antibody response of the mouse. II. In vitro activity and evidence for the I region gene product, J. Exp. Med. 116: 542–548.
Ten Napel, C. H. H., The, T. H., Bijaker, J., DeGast, G. C., and Langenhuysen, M. M. A. C., 1977, Cytomegalovirus-directed lymphocyte reactivity in healthy adults tested by a CMV-induced lymphocyte transformation test, Clin. Exp. Immunol. 29: 52–60.
Thomson, P. D., and Harris, N. S., 1977, Detection of plaque-forming cells in the peripheral blood of actively immunized humans, J. Immunol. 118: 1480–1482.
Touraine, J. L., Kiszkiss, D. F., Choi, Y. S., and Good, R. A., 1973, T-cells in immunodeficiencies as evaluated by an anti-human T-cell serum, Birth Defects 11 (1): 22–27.
Touraine, J. L., Touraine, F., Hadden, J. W., Hadden, E. M., and Good, R. A., 1976, 5-bromodeoxyuridine-light inactivation of human lymphocytes stimulated with mitogens and allogeneic cells: Evidence for distinct T lymphocyte subsets, Int. Arch. Allergy Appl. Immunol. 52: 105–117.
Treves, A. J., Heidelberger, E., and Kaplan, H. S., 1979, In vitro sensitization of human lymphocytes against histiocytic lymphoma cell lines. III. The activity of culture-induced suppressor cells, J. Immunol. 122: 643–647.
Troye, M., Perlmann, P., Pape, G. R., Spiegelberg, H. L., Näsland, I., and Gidloff, A., 1977, The use of Fab fragments of anti-human immunoglobulin as analytic tools for establishing the involvement of immunoglobulin in the spontaneous cytotoxicity to cultured tumor cells by lymphocytes from patients with bladder carcinoma and from healthy donors, J. Immunol. 119: 1061–1067.
Twomey, J. J., Laughter, A. H., Farrow, S., and Douglass, C. C., 1975, Hodgkin’s disease, an immunodepleting and immunosuppressive disorder, J. Clin. Invest. 56: 467–475.
Unanue, E. R., and Cerottini, J. C., 1970, The immunogenicity of antigen bound to the plasma membrane of macrophages, J. Exp. Med. 131: 711–725.
Van Rood, J. J., van Hoof, J. P., Keuning, J. J., and Bleusse van Oud Alblas, A., 1975, The serological recognition of the human MLC determinants using a modified cytotoxicity test, Tissue Antigens 5 (2): 73–79.
Waldman, R., and Henney, C. S., 1971, Cell-mediated immunity and antibody response in the respiratory tract after local and systemic immunization, J. Exp. Med. 134: 482–494.
Waldman, T. A., Durm, M., Broder, S., Blackman, M., Blaese, R. M., and Strober, W., 1974, Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinemia, Lancet 2: 609.
Wang, J. L., McClain, D. A., and Edelman, G. M., 1975, Modulation of lymphocyte mitogenesis, Proc. Natl. Acad. Sci. USA 72: 1917–1921.
Weber, T. H., 1969, Isolation and characterization of a lymphocyte-stimulating leucoagglutinin from red kidney beans, Scand. J. Clin. Invest. Suppl., 1: 11.
Wedner, H. J., and Parker, C. W., 1975, Protein phosphorylation in human peripheral lymphocytes-Stimulation by phytohemagglutinin and N6 monobutyryl cyclic AMP, Biochem. Biophys. Res. Commun. 62: 808–815.
West, W. H., Boozer, R. B., and Herberman, R. B., 1978, Low affinity E-rosette formation by the human K cell, J. Immunol. 120: 90–95.
Wiig, L. N., and Thunbold, S., 1973, Electrophoresis of lymphoid cells. Characterization of human B and T cells in peripheral lymphoid tissues, Clin. Exp. Immunol. 15: 497–506.
Willoughby, E., Dupont, B., Hansen, J. A., and Good, R. A., 1978, The indirect assay for leukocyte migration inhibition factor (LIF) -Standardization and effect of pH, J. Immunol. Methods 27: 99–110.
Winchester, R. J., Wang, C. Y., Halper, J., and Hoffman, T., 1976, Studies with B-cell allo-and hetero-antisera: Parallel reactivity and special properties, Scand. J. Immunol. 5: 745–757.
Woody, J. N., Ahmed, A., Knudson, R. C., Strong, D. M., and Sell, K. W., 1975, Human T-cell heterogeneity as delineated with a specific human thymus lymphocyte antiserum, J. Clin. Invest. 55: 956–966.
Wortis, H. H., Cooper, A. G., and Brown, M. C., 1973, Inhibition of human lymphocyte rosetting by anti-T sera, Nature (London) 243: 109–111.
Wybran, J., Carr, M. C., and Fudenberg, H. H., 1972, The human rosette forming cell as a marker of a population of thymus-derived cells, J. Clin. Invest. 51: 2537–2543.
Yahara, I., and Edelman, G. M., 1972, Restriction of the mobility of lymphocyte immunoglobulin receptors by concanavalin A, Proc. Natl. Acad. Sci. USA 69: 60–8612.
Yahara, I., and Edelman, G. M., 1973, Modulation of lymphocyte receptor redistribution by concanavalin A, anti-mitotic agents and alterations of pH, Nature (London) 236: 152–155.
Yata, J., Klein, G., Kogayashi, N., Furukawa, T., and Yanagisawa, M., 1970. Human thymus-lymphoid tissue antigen and its presence in leukemia and lymphoma, Clin. Exp. Immunol. 7: 781–792.
Yata, J., Desgranges, C., Tachibana, G., and The, G., 1973, Separation of human lymphocytes forming spontaneous rosettes with sheep red cells, Biomedicine 19: 475–478.
Young, N. M., Leon, M. A., Takahashi, T., Howard, I. K., and Sage, H. J., 1971, Studies on a phytohemagglutinin from the lentil. III. Reaction of Lens culinaris hemagglutinin with polysaccharides, glycoproteins and lymphocytes, J. Biol. Chem. 246: 1596–1601.
Zaia, J. A., Leary, P. L., and Levin, M. J., 1978, Specificity of the blastogenic response of human mononuclear cells to herpesvirus antigens, Infect. Immun. 20: 646–651.
Zembala, M., Mytar, B., Popielta, T., and Asherson, C. C., 1977, Depressed in vitro peripheral blood lymphocyte response to mitogens in cancer patients: The role of suppressor cells, Int. J. Cancer 19: 605–613.
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© 1981 Plenum Publishing Corporation
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Cunningham-Rundles, S. (1981). Cell-Mediated Immunity. In: Safai, B., Good, R.A. (eds) Immunodermatology. Comprehensive Immunology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7228-2_1
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