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HTLV-I Tax

A Paradigm for How a Single Auxiliary Factor Can Regulate the Expression of Viral and Cellular Genes

  • Chapter
Cancer Genes

Part of the book series: Pezcoller Foundation Symposia ((PFSO,volume 7))

  • 48 Accesses

Abstract

Human T-cell Leukemia Virus type I (HTLV-I) is a human retrovirus that causes disease mainly in the Mediterranean and south tropical areas such as Southern Europe, Middle East, Japan, Philippines, South America, Caribbean and Central Africa1, 2. It is spread from mother to child perinatally or by breast feeding. Transfer from one individual to another can also occur by sexual contact and infected blood. Although it is asymptomatic in the vast majority of the population, a relatively small (< 4%) but still significant number of individuals develops after several years from the onset of the infection, a severe adult T cell leukemia (ATL)3 or the so-called tropical spastic paraparesis (TSP)4, also known as a HTLV-I associated myelopathy (HAM), a neurological disorder characterized by a slow and progressive demyelination of the peripheral nerves and causing paraparesis and spasticity of the lower extremities. Moreover, HTLV-I can also cause a severe granulocytosis and eosinophilia5 and in some cases an autoimmune chronic athritis6.

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Authors and Affiliations

  1. Howard Hughes Medical Institute, Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts, 01605, USA

    Giovanni Perini & Michael R. Green

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  1. Giovanni Perini
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  2. Michael R. Green
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  1. Roswell Park Cancer Institute, Buffalo, New York, USA

    Enrico Mihich

  2. MIT Center for Cancer Research, Cambridge, Massachusetts, USA

    David Housman

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© 1996 Springer Science+Business Media New York

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Perini, G., Green, M.R. (1996). HTLV-I Tax. In: Mihich, E., Housman, D. (eds) Cancer Genes. Pezcoller Foundation Symposia, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5895-8_7

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  • DOI: https://doi.org/10.1007/978-1-4615-5895-8_7

  • Publisher Name: Springer, Boston, MA

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