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P53-Mediated Apoptosis

Regulatory and Mechanistic Aspects

  • Chapter
Cancer Genes

Part of the book series: Pezcoller Foundation Symposia ((PFSO,volume 7))

Abstract

The p53 gene is an important tumor suppressor gene, whose inactivation appears to play a pivotal role in many types of cancer1–3. The p53 protein, encoded by this gene, is a potent sequence-specific transcriptional activator4,5. Binding of the p53 protein to genes which contain consensus p53 binding sites results in a pronounced increase in their transcription rates6–11. Transcriptional activation of relevant target genes, mediated through high affinity sequence-specific DNA binding, is believed to be responsible for many of the biological effects of the wild-type p53 (wt p53) protein. This is supported by the fact that the overwhelming majority of p53 mutations found in human tumors abrogate DNA binding, either by altering direct DNA contact residues or through destabilizing the structure of the DNA binding domain12,13.

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Authors and Affiliations

  1. Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel

    Ygal Haupt, Sheldon Rowan, Eitan Shaulian, Eyal Gottlieb & Moshe Oren

  2. Lab. Oncologie Moleculaire, IRSC, 94891, Villejuif Cedex, France

    Elisheva Yonish-Rouach

  3. NCI-Frederick Research and Development Center, Frederick, Maryland, 21702, USA

    Karen Vousden

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  1. Ygal Haupt
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  1. Roswell Park Cancer Institute, Buffalo, New York, USA

    Enrico Mihich

  2. MIT Center for Cancer Research, Cambridge, Massachusetts, USA

    David Housman

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Haupt, Y. et al. (1996). P53-Mediated Apoptosis. In: Mihich, E., Housman, D. (eds) Cancer Genes. Pezcoller Foundation Symposia, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5895-8_5

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  • DOI: https://doi.org/10.1007/978-1-4615-5895-8_5

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