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Homeostatic Mechanisms Governing the Go Phase as Defined by the gas Genes

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Cancer Genes

Part of the book series: Pezcoller Foundation Symposia ((PFSO,volume 7))

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Summary

Control of proliferation in animal cells is defined by the possible alternative fates that can be chosen, namely differentiation, apoptosis, cell division cycle or Go reversible growth arrest. Here we consider the known biological activities of a set of genes named gas (growth arrest specific) that are expressed during Go in NIH3T3 fibroblasts thus identifying an intrinsic genetic program involved in the maintenance of Go.

The products of the gas genes show activities that interfere both positively and negatively with the potential of Go cells to re-enter the cell division cycle or to undergo apoptosis thus demonstrating that Go is quite a dynamic state.

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Authors and Affiliations

  1. Laboratorio Nazionale C.I.B. (Consorzio Interuniversitario per le Biotecnologie, Area Science Park, 99 Padriciano, 34012, Trieste, Italy

    Claudio Schneider, Giannino Del Sal, Claudio Brancolini, Elisabetta Ruaro & Sandro Goruppi

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  1. Claudio Schneider
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  2. Giannino Del Sal
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  3. Claudio Brancolini
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  4. Elisabetta Ruaro
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  5. Sandro Goruppi
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Editors and Affiliations

  1. Roswell Park Cancer Institute, Buffalo, New York, USA

    Enrico Mihich

  2. MIT Center for Cancer Research, Cambridge, Massachusetts, USA

    David Housman

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© 1996 Springer Science+Business Media New York

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Schneider, C., Del Sal, G., Brancolini, C., Ruaro, E., Goruppi, S. (1996). Homeostatic Mechanisms Governing the Go Phase as Defined by the gas Genes. In: Mihich, E., Housman, D. (eds) Cancer Genes. Pezcoller Foundation Symposia, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5895-8_12

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  • DOI: https://doi.org/10.1007/978-1-4615-5895-8_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7704-7

  • Online ISBN: 978-1-4615-5895-8

  • eBook Packages: Springer Book Archive

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