Abstract
Cyclin A function is required for a successful S phase of the mammalian cell cycle(Girard et al., 1991; Pagano et al., 1992; Zindy et al., 1992). In this role, it functions in complex with its cdk partner, cdk2 (Pines and Hunter, 1990), and it is the cyclin A-cdk2-dependent phosphorylation of selected target proteins at the appropriate time in the cell cycle which translates into the successful prosecution of its S phase function. This notwithstanding, there has been no clear understanding of the nature of critical cyclin A-cdk2 targets. Thus, the identification and functional characterization of physiologically relevant substrates of this enzyme remains a major problem, which must be solved if one is to understand, in detail, how cyclin A controls S phase progression.
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Krek, W., Xu, G., Livingston, D.M. (1996). Cyclin A-Kinase Binding to and Regulation of the Function of a Growth-Promoting Transcription Factor. In: Mihich, E., Housman, D. (eds) Cancer Genes. Pezcoller Foundation Symposia, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5895-8_11
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DOI: https://doi.org/10.1007/978-1-4615-5895-8_11
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