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Angiotensin II, Growth Factors and the Lipoxygenase Pathway

  • Chapter
Endocrinology of Cardiovascular Function

Part of the book series: Endocrine Updates ((ENDO,volume 1))

Abstract

Excessive proliferation and migration of vascular smooth muscle cells have been implicated in the pathogenesis of atherosclerosis and restenosis after balloon angioplasty. These processes are mainly mediated by growth factors and cytokines released by various cells in the vessel wall. However, the role of free lipids in these events are not very clear. Vascular smooth muscle cell growth factors and cytokines can activate phospholipases with the release of arachidonic acid which can be further metabolized by several pathways including the lipoxygenase pathway. Lipoxygenase products have been shown to have potent inflammatory, growth and chemoattractant effects in cells. This chapter examines the role of the lipoxygenase pathway in the growth promoting effects of angiotensin II and the chemotactic effects of platelet-derived growth factor in vascular smooth muscle cells. In addition, this chapter also examines the effects of hyperglycemia on the regulation and function of the lipoxygenase pathway, in order to evaluate potential mechanisms for the accelerated cardiovascular disease observed in diabetics.

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Authors and Affiliations

  1. Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center, Duarte, CA, 91010, USA

    Rama Natarajan & Jerry Nadler

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  1. Rama Natarajan
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  2. Jerry Nadler
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Editors and Affiliations

  1. DVA Medical Center and University of California, Irvine, USA

    Ellis R. Levin M.D.

  2. City of Hope Medical Center, Duarte, California, USA

    Jerry L. Nadler M.D.

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Natarajan, R., Nadler, J. (1998). Angiotensin II, Growth Factors and the Lipoxygenase Pathway. In: Levin, E.R., Nadler, J.L. (eds) Endocrinology of Cardiovascular Function. Endocrine Updates, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5569-8_4

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  • DOI: https://doi.org/10.1007/978-1-4615-5569-8_4

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