Abstract
Cooperation between macrophages and T-lymphocytes is necessary for the development of cell-mediated immune (CMI) responses (Hibbs et al., 1990). It has long been understood that the CMI response is important in host defense against intracellular microorganisms (Mackaness, 1971; Hibbs et al., 1980). What was not known until relatively recently, however, was the identity of an important biochemical defense, induced during the CMI response as well as during innate resistance. As is now well documented, the unidentified defense system turned out to be cytokine induced biosynthesis of nitric oxide (NO). This previously unknown biochemical activity participates in defense of the host against certain intracellular pathogens, and has a complex role in the host-tumor interaction.
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Hibbs, J.B., Bastian, N.R. (1998). Interactions Between Cytokine Induced Nitric Oxide and Intracellular Iron. In: Lukiewicz, S., Zweier, J.L. (eds) Nitric Oxide in Transplant Rejection and Anti-Tumor Defense. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5081-5_14
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DOI: https://doi.org/10.1007/978-1-4615-5081-5_14
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