Abstract
Although many of the published TMR clinical reports are encouraging [1–3], the procedure remains controversial, primarily because the mechanism of the reported clinical improvement is unknown. Previous work demonstrated that transmural channels made in sheep hearts with an excimer laser [4] and in rat hearts with a hypodermic syringe needles [5] stayed open for at least one month, and in the case of the needle channels, provided protection against subsequent coronary artery occlusion. Nevertheless, these results are in sharp contrast to the closed channels found after holmium: YAG and carbon dioxide laser treatment in dog and pig hearts [6–8]. Our explanation for these conflicting data was that channels remain patent only if injury to tissue surrounding the channels is small; a feature not often reported after channel-making with infrared lasers such as the holmium: YAG and carbon dioxide.
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Whittaker, P., Spariosu, K., Ho, ZZ. (1999). Initial Use of an Ultraviolet Laser for TMR. In: Whittaker, P., Abela, G.S. (eds) Direct Myocardial Revascularization: History, Methodology, Technology. Developments in Cardiovascular Medicine, vol 211. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5069-3_7
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DOI: https://doi.org/10.1007/978-1-4615-5069-3_7
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