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Surface Protein Phosphorylation by Ecto-Protein Kinases

Role in Neuronal Development and Synaptic Plasticity

  • Chapter
Molecular and Cellular Mechanisms of Neuronal Plasticity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 446))

Abstract

Specific patterns of neuronal development in the brain are determined by complex interactions occurring at cell surfaces, but little is known about the enzymatic events that regulate these interactions. Protein phosphorylation, a ubiquitous step in intracellular pathways that produce rapid and transient changes in neuronal activity (Greengard, 1978; Nes-tler and Greengard, 1983; Ehrlich, 1984), was found to operate also as a key mechanism of molecular adaptation in processes whereby hormonal, pharmacological and behavioral inputs influence neuronal development and induce long-lasting alterations in neuronal function (Ehrlich and Routtenberg, 1975; Ehrlich et al., 1977, 1987: Neary et al., 1981; Kandel and Schwartz, 1982). The discovery of neuronal ecto-protein kinase activity (Ehrlich et al.,1986) has revealed that the powerful regulatory mechanism of protein phosphorylation operates also in the extracellular environment of the nervous system. In this location, the regulation of delicate interactions among cells, and between surface proteins and components of the extracellular matrix, can determine patterns of neuronal connectivity and thus play a significant role in processes underlying synaptic plasticity.

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Authors and Affiliations

  1. The Department of Biology and the CSI/IBR Center for Developmental Neuroscience, USA

    Yigal H. Ehrlich, Michael V. Hogan, Zofia Pawlowska, Andrzej Wieraszko, Ethel Katz, Tomasz Sobocki, Anna Babinska & Elizabeth Kornecki

  2. The College of Staten Island of The City University of New York, 2800 Victory Boulevard, Staten Island, New York, 10314, USA

    Yigal H. Ehrlich, Michael V. Hogan, Zofia Pawlowska, Andrzej Wieraszko, Ethel Katz, Tomasz Sobocki, Anna Babinska & Elizabeth Kornecki

  3. The Department of Anatomy and Cell Biology, State University of NY Health Science Center at Brooklyn, Brooklyn, New York, 11203, USA

    Yigal H. Ehrlich, Michael V. Hogan, Zofia Pawlowska, Andrzej Wieraszko, Ethel Katz, Tomasz Sobocki, Anna Babinska & Elizabeth Kornecki

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  1. The College of Staten Island of The City University of New York, USA

    Yigal H. Ehrlich

  2. The CSI/IBR Center for Developmental Neuroscience Staten Island, New York, USA

    Yigal H. Ehrlich

  3. The City University Graduate School, New York, New York, USA

    Yigal H. Ehrlich

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Ehrlich, Y.H. et al. (1998). Surface Protein Phosphorylation by Ecto-Protein Kinases. In: Ehrlich, Y.H. (eds) Molecular and Cellular Mechanisms of Neuronal Plasticity. Advances in Experimental Medicine and Biology, vol 446. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4869-0_4

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