Skip to main content

Aging and Dementia of the Alzheimer type in Persons with Mental Retardation

  • Chapter
Molecular and Cellular Mechanisms of Neuronal Plasticity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 446))

Abstract

Aging during the senior years is part of the normal process of life span development. We are born, mature, and if we are fortunate, we grow old before we die. Unfortunately, the process of growing old is associated with declining status in many respects, physical and cognitive. These declines can be related to the concept of reserve: the greater the reserve the longer the organism will be able to avoid any functional deficit. Disease processes, by and large, appear to diminish our reserves. Therefore, in persons suffering from various diseases, age-associated functional impairments are observed earlier and the life span may be shortened.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Barcikowska, M., Wisniewski, H.M., Bancher, C., and Grundke-Iqbal, I. (1989) About the presence of paired helical filaments in dystrophic neurites participating in the plaque formation. Acta Neuropathol. 78, 225–231.

    Article  PubMed  CAS  Google Scholar 

  • Brown, W.T., and Wisniewski, H.M. (1983) Genetics of human aging. Review of biological research. Aging 1, 81–99.

    Google Scholar 

  • Ellis, W.G., McCulloch, J.R., and Corley, C.L. (1974) Presenile dementia in Down’s syndrome. Neurology 24, 101–106.

    Article  PubMed  CAS  Google Scholar 

  • Popovitch, E.R., Wisniewski, H.M., Barcikowska, M., Silverman, W., Bancher, C., Sersen, E., and Wen, G.Y. (1990) Alzheimer neuropathology in non-Down’s syndrome mentally retarded adults. Acta Neuropathol. 80, 362–367.

    Article  PubMed  CAS  Google Scholar 

  • Wegiel, J., Wisniewski, H.M., Dziewiatkowski, J., Popovitch, E.R., and Tarnawski, M. (1996) Differential susceptibility to neurofibrillary pathology among patients with Down syndrome. Dementia 7, 135–141

    PubMed  CAS  Google Scholar 

  • Wisniewski, H.M., and Rabe, A. (1986) Discrepancy between Alzheimer-type neuropathology and dementia in persons with Down’s syndrome. Annals N.Y. Acad. Sci. 477, 247–260.

    Article  CAS  Google Scholar 

  • Wisniewski, H.M., Silverman, W., and Wegiel, J. (1994a) Aging, Alzheimer disease and mental retardation. J. Intellect. Disabil. Res. 38, 233–239.

    Article  PubMed  Google Scholar 

  • Wisniewski, H.M., Wegiel, J., Kotula, L. (1996) Some neuropathological aspects of Alzheimer’s disease and its relevance to other disciplines. Neuropathol. Appl. Neurobiol. 22, 3–11.

    Article  PubMed  CAS  Google Scholar 

  • Wisniewski, H.M., Wegiel, J., and Popovitch, E.R. (1994b) Age-associated development of diffuse and thioflav-ine-S-positive plaques in Down syndrome. Dev. Brain Dysfunct. 7, 330–339.

    Google Scholar 

  • Wisniewski, H.M., Wen, G.Y., Grundke-Iqbal, I., Iqbal, K., Mehta, P.D., Merz, P.A., Miller, D., Currie, J., Bobin, S.A., Robakis, N.K., Rabe, A., and Brown, W.T. (1987) Pathological, biochemical, and genetic aspects of Alzheimer’s disease in aged people and Down syndrome, in Contributions of Chemistry to Health (Machleidt, H., ed), pp. 297–315. Proceedings of the Fifth CHEMRAWN Conference, Heidelberg, Germany.

    Google Scholar 

  • Wisniewski, H.M., Wen, G.Y., and Kim, K.S. (1989) Comparison of four staining methods on the detection of neuritic plaques. Acta Neuropathol. 78, 225–231.

    Article  PubMed  Google Scholar 

  • Zigman, W., Silverman, W., and Wisniewski, H.M. (1996) Aging and Alzheimer’s disease in Down syndrome: Clinical and pathological changes. Mental Retardation & Developmental Dis. Res. Reviews 2, 73–79.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media New York

About this chapter

Cite this chapter

Wisniewski, H.M., Silverman, W. (1998). Aging and Dementia of the Alzheimer type in Persons with Mental Retardation. In: Ehrlich, Y.H. (eds) Molecular and Cellular Mechanisms of Neuronal Plasticity. Advances in Experimental Medicine and Biology, vol 446. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4869-0_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-4869-0_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7209-7

  • Online ISBN: 978-1-4615-4869-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics