Abstract
Hydroxy fatty acids (OH-FAs) including 3-OH-FA are widely distributed in microorganisms (Schweizer, 1989). Thus, the production of 3-OH-FA by fungi has been reported in various studies (Van Dyk et al., 1994). Using thin-layer chromatography, autoradiography, 1H-NMR as well as gas chromatography-mass spectrometry, we isolated and identified the novel 3-hydroxyeicosanoid (3R)-hydroxy-(5Z,8Z,llZ,14Z)-eicosatetraenoic acid (3-HETE) from the yeast Dipodascopsis uninucleata following incubation with arachidonic acid (Van Dyk et al., 1991; Venter et al., 1997). This compound now turned out to be the prototype of the new family of fungal unsaturated bioactive (3R)-hydroxy-oxylipins (see Nigam et al., this volume).
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References
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Kock, J.L.F. et al. (1999). Production of 3-Hydroxy Fatty Acids by the Yeast Dipodascopsis Uninucleata. Biological Implications. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E.A. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4. Advances in Experimental Medicine and Biology, vol 469. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4793-8_97
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