Abstract
Renal papillary necrosis (RPN) develops in the course of a variety of diseases in which the principle morphologic changes are those of tubulointerstitial nephritis (TIN) which is characteristically more severe in, and at times limited to, the inner medulla of the kidney (1). The focal or diffuse necrosis of the distal segments of one or more of the renal pyramids is ischemic in origin (2, 3). In the affected papillae the lesion is generally well demarcated and coagulative necrosis is the most prominent feature observed on histologic examination. The fact that necrosis is anatomically confined to the most distal segments of the inner medulla is, most likely,due to the unique structural and functional features of the renal papillae.
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References
Eknoyan, G., Qunibi, W. Y., Grissom, R. T., Tuma, S. N., and Ayus, J. C. Medicine 61: 55–73, 1982.
Lagergren, C. and Ljunggvist, A. Am. J. Pathol. 41: 633–643, 1962.
Nanra, R. S., Chirawong, P. and Kincaid-Smith, P. Aust. N.Z. J. Med. 3: 580–586, 1973.
Dobyan, D. C. and Jamison, R. L. Semin. Nephrol. 4: 5–26, 1984.
Pfaller, W. and Rittinger, M. Int. J. Biochem. 12: 17–22, 1980.
Shyan-Yih, C., Porush, J. G. and Gaubert, P. F. Kidney Int. 37: 1–13, 1990.
Wylie, R. G., Hill, G. S., Murray, G., Ramsden, P. W. and Hepstinstall, R. H. Am. J. Pathol. 68: 235–253, 1972.
Chernew, I. and Brande, A. I. J. Clin. Invest. 41: 1945–1953, 1962.
Nath, K. A., Hostetter, M. K. and Hostetter, T. H. J. Clin.Invest. 76: 667–675, 1985.
Friedreich, N. Virchow Arch. Path. Anat. 69: 308–312, 1877.
Eknoyan, G. In: The Kidney and Hypertension in Diabetes Mellitus (ed. C. E. Mogensen), Martinus Nijhoff Publishing, Boston, 1988, pp. 259–267.
Statius Van Eps, L. W., Pinedo-Veels, C., De Vries, G. H. and De Koning, J. Lancet 1: 450–451, 1970.
Eknoyan, G. Semin. Nephrol. 4: 65–76, 1984.
Lindvall, N. Kidney Int. 13: 93–106, 1978.
Vaamonde, C. A. Semin. Nephrol. 4: 48–64, 1984.
Robbins, S. L., Mallory, G. K. and Kinney, T. D. N. Engl. J. Med. 235: 885–893, 1946.
Mandel, E. E. Am. J. Med. 29: 322–327, 1952.
Lauler, D. P., Schreiner, G. E. and David, A. Am. J. Med. 29: 132–156, 1960.
Hultengren, N. Acta Chir. Scand. (Suppl.) 277: 1–84, 1961.
Sabatini, S. Semin. Nephrol. 4: 27–39, 1984.
Mujais, S. Semin. Nephrol. 4: 40–47, 1984.
Edmondson, H. A., Martin, H. E. and Evans, N. Arch. Int. Med. 79: 148–175, 1947.
Kaude, J. V., Stone, M., Fuller, T. J., Cade, J. R., Tarrant, D. G. and Juncos, L. L. Radiology 120: 69–74, 1976.
Axelsen, R. A. and Burry, A. F. Pathology 4: 225–229, 1972.
Sheehan, H. L. and Davis, J. C. Arch. Pathol. 68: 185–225, 1959.
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© 1991 Springer Science+Business Media New York
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Eknoyan, G. (1991). Renal Papillary Necrosis and Tubulo-Interstitial Nephritis. In: Amerio, A., Coratelli, P., Massry, S.G. (eds) Tubulo-Interstitial Nephropathies. Developments in Nephrology, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3892-9_15
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DOI: https://doi.org/10.1007/978-1-4615-3892-9_15
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