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Enzyme-Directed Bioreductive Drug Development

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Selective Activation of Drugs by Redox Processes

Part of the book series: NATO ASI Series ((NSSA,volume 198))

Abstract

By definition, bioreductive anticancer agents require metabolic reduction to generate toxic species. In the case of bioreductive alkylating agents, activation by reductase enzymes is reversed by molecular oxygen. In some cases bioreduction can lead to detoxification. Thus the specificity of bioreductive drugs will be dependent upon the relative activities of appropriate activating and deactivating reductases in tumour versus normal tissues, as well as the comparative oxygen levels. Considerably greater attention has been focused upon oxygen as a controlling factor. Our complementary approach has been to concentrate on the molecular enzymology of reductive bioactivation.

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Author information

Authors and Affiliations

  1. Clinical Oncology Unit, MRC Centre, Hills Road, Cambridge, CB2 2QH, UK

    Paul Workman & Michael I. Walton

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  1. Paul Workman
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  2. Michael I. Walton
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Editor information

Editors and Affiliations

  1. MRC Radiobiology Unit, Didcot, Chilton, Oxon., OX11 ORD, UK

    G. E. Adams  & E. M. Fielden  & 

  2. Facoltà di Farmacia, Istituto di Scienze Chimiche, Università Degli Studi di Bologna, 40127, Bologna, Via S. Donato, 15, Italy

    A. Breccia

  3. CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, HA6 2JR, UK

    P. Wardman

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© 1990 Springer Science+Business Media New York

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Workman, P., Walton, M.I. (1990). Enzyme-Directed Bioreductive Drug Development. In: Adams, G.E., Breccia, A., Fielden, E.M., Wardman, P. (eds) Selective Activation of Drugs by Redox Processes. NATO ASI Series, vol 198. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3768-7_16

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  • DOI: https://doi.org/10.1007/978-1-4615-3768-7_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6679-9

  • Online ISBN: 978-1-4615-3768-7

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