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Lactic Acid Bacteria in the Support of Immuno-compromised Hosts

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The Lactic Acid Bacteria Volume 1

Abstract

Severe microbial infections are frequently present in immuno-compromised patients, such as due to malignant tumours, organ graft, thermal injury and in particular acquired immuno-deficiency syndrome (AIDS). In these cases, the opportunistic infections are generally caused by parasites with high drug resistance, such as aerobic or facultatively anaerobic Gram-negative rods (Pseudomonas, Xanthomonas, Achromobacter, Serratia, Klebsiella, Proteus, etc.), non-endospore-forming anaerobic rods (Bacteroides, Fusobacterium, etc.), Staphylococcus (especially methicillin-resistant S. aureus and cloxacillin-resistant S. epidermidis), non-tuberculous mycobacteria (Mycobacterium avium-intracellulare complex, M. scrofulaceum, M. kansasii, etc.), fungi (Candida, Aspergillus, Cryptococcus, etc.), viruses (Herpesvirus, Cytomegalovirus, etc.), and Protozoa (Pneumocystis carinii and Toxoplasma gondii). Thus, clinical control of the opportunistic infections using anti-microbials is very difficult, and a wide spectrum of disease manifestations, persistent infections, and disseminated diseases are frequently encountered. Therefore, it is important to provide a device to restore or enhance the lowered immune functions in compromised patients, using biological response modifiers (BRMs).

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  1. Department of Microbiology and Immunology, Shimane Medical University, Izumo, Shimane, 693, Japan

    Haruaki Tomioka & Hajime Saito

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  1. Haruaki Tomioka
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  1. Department of Bioscience and Biotechnology, University of Strathclyde, Glasgow, UK

    Brian J. B. Wood

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Tomioka, H., Saito, H. (1992). Lactic Acid Bacteria in the Support of Immuno-compromised Hosts. In: Wood, B.J.B. (eds) The Lactic Acid Bacteria Volume 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3522-5_11

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  • DOI: https://doi.org/10.1007/978-1-4615-3522-5_11

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