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Monoclonal antibodies in the treatment of myelogenous leukemias

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Leukemia: Advances in Research and Treatment

Part of the book series: Cancer Treatment and Research ((CTAR,volume 64))

Abstract

Monoclonal antibodies (mAb) differ dramatically from conventional therapeutic agents in their mechanisms of actions and in their biochemical and biological properties [1–3]. On the one hand, mAbs are capable of selective targeting of tumor cells while avoiding normal tissues. MAbs are able to kill tumor cells via a variety of intrinsic (immunological) and extrinsic (by use of carried cytotoxic agents) modes. On the other hand, these molecules are large, poorly diffusible into areas of bulky disease, and highly immunogenic, rendering repeated infusions difficult. These advantages and disadvantages must be carefully considered in the application of mAb to the treatment of hematopoietic cancers.

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Authors
  1. David A. Scheinberg
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Editors and Affiliations

  1. M.D. Anderson Cancer Center, The University of Texas, USA

    Emil J. Freireich  & Hagop Kantarjian  & 

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© 1993 Springer Science+Business Media New York

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Scheinberg, D.A. (1993). Monoclonal antibodies in the treatment of myelogenous leukemias. In: Freireich, E.J., Kantarjian, H. (eds) Leukemia: Advances in Research and Treatment. Cancer Treatment and Research, vol 64. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3086-2_11

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  • DOI: https://doi.org/10.1007/978-1-4615-3086-2_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6348-4

  • Online ISBN: 978-1-4615-3086-2

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