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Potential Role of Endosomes in Transmembrane Signaling

  • Chapter
Endocytic Components: Identification and Characterization

Part of the book series: Subcellular Biochemistry ((SCBI,volume 19))

Abstract

After ligands bind to their surface receptors on target cells, the ligand-receptor complexes undergo aggregation and internalization. This process of receptormediated endocytosis leads to the concentration of ligand-receptor complexes in a heterogeneous population of tubulovesicular structures that has been distinguished from plasma membrane, lysosomes, and Golgi elements. These structures, now called endosomes, are not clearly characterized by a specific enzyme or protein marker but rather by their unique property to concentrate internalized ligand-receptor complexes. It is widely appreciated that, within endosomes, ligand-receptor complexes are directed toward dissociation and receptor recycling or toward transcytosis, with ligand undergoing degradation in the former situation or transcellular passage in the latter. It has been suggested that, in addition to this sorting function, endosomes play a role in signal transduction.

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  1. M. N. Khan

    Present address: Phoenix International Life Sciences, Montreal, Canada, H4R 2N6

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  1. Department of Anatomy, McGill University, Montreal, Canada, H3A 2B2

    M. N. Khan, W. H. Lai, J. W. Burgess & J. J. M. Bergeron

  2. Department of Medicine, McGill University, Montreal, Canada, H3A 2B2

    B. I. Posner

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  1. Department of Anatomy, McGill University, Montreal, Canada

    J. J. M. Bergeron

  2. Institute of Zoology, University of Mainz, Mainz, Germany

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Khan, M.N., Lai, W.H., Burgess, J.W., Posner, B.I., Bergeron, J.J.M. (1993). Potential Role of Endosomes in Transmembrane Signaling. In: Bergeron, J.J.M., Harris, J.R. (eds) Endocytic Components: Identification and Characterization. Subcellular Biochemistry, vol 19. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3026-8_8

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