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Chemotactic and Inflammatory Cytokines — CXC and CC Proteins

  • Chapter
The Chemokines

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 351))

Abstract

This is the third meeting in about three years on a family of cytokines that became fancy with the discovery of interleukin-8 (IL-8). The IL-8-related cytokines are small, and relatively easy to work with. They are characterized by four conserved cysteine residues. Alignment of these residues differentiates two subfamilies: one with the first two cysteines separated by one amino acid (CXC cytokines), and the other with adjacent cysteines (CC cytokines). The genes for the two clans inhabit different chromosomes, number 4 for the CXC and number 17 for the CC, and the cytokines that they produce have different target cell preferences.

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Authors and Affiliations

  1. Theodor-Kocher Institute, University of Bern, P.O. Box CH-3000- BERN-9, Switzerland

    Marco Baggiolini

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  1. Sandoz Research Institute, Vienna, Austria

    I. J. D. Lindley

  2. University of Bath, Bath, UK

    J. Westwick

  3. University of Michigan, Ann Arbor, Michigan, USA

    S. Kunkel

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Baggiolini, M. (1993). Chemotactic and Inflammatory Cytokines — CXC and CC Proteins. In: Lindley, I.J.D., Westwick, J., Kunkel, S. (eds) The Chemokines. Advances in Experimental Medicine and Biology, vol 351. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2952-1_1

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  • DOI: https://doi.org/10.1007/978-1-4615-2952-1_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6283-8

  • Online ISBN: 978-1-4615-2952-1

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