Abstract
The effects of extracellular ATP on the L-type Ca2+ current (ICa), action potential, and resting and intracellular Ca2+ levels were examined in enzymatically isolated myocytes from the right ventricles of ferrets. Extracellular ATP decreased the peak amplitude of ICa in a time- and concentration-dependent manner. The concentration-response relationship for ATP inhibition of ICa was well described by a conventional Michaelis-Menten relationship with a half maximal inhibitory concentration of IRM and a maximal effect of 50%. Extracellular ATP did not change the resting myoplasmic Ca2+ levels; however, it did decrease the Ca2+ transient. The effects of extracellular ATP were mediated independently of adenosine Al receptors and a pertussis-toxin sensitive G protein. Pharmacological characterization of receptor subtype using ATP analogs was consistent with ATP binding to a P2Y type receptor.
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Qu, Y., Campbell, D.L., Himmel, H.H., Strauss, H.C. (1993). Neuromodulation of Calcium Current by Extracellular ATP in Isolated Ventricular Myocytes. In: Sideman, S., Beyar, R. (eds) Interactive Phenomena in the Cardiac System. Advances in Experimental Medicine and Biology, vol 346. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2946-0_2
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DOI: https://doi.org/10.1007/978-1-4615-2946-0_2
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