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Regulation of β1 Integrin-Mediated Adhesive Functions

  • Chapter
Cell Adhesion Molecules

Part of the book series: Pezcoller Foundation Symposia ((PFSO,volume 4))

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Abstract

The integrin family includes receptors for extracellular matrix (ECM) components as well as receptors involved in cell-cell adhesive interactions (Hynes R.O 1992; Hemler, M.E, 1990; Springer, T.A, 1990; Rouslahti, E, 1991). The VLA subfamily of integrins is comprised of at least eight heterodimers, each with a common β subunit (the β1 chain) noncovalently associated with one of eight different α subunit (Hynes, R.O, 1992; Hemler, M.e, 1990). In addition to α:β1 heterodimers, novel associations of α and alternative β subunits have been found which expand the molecular and functional reperoire of integrins (Hynes, R.O, 1992; Hemler, M.E, 1990). The involvement of VLA integrins in cell interactions either with extracellular matrix (ECM) components or with cellular liands, appears to be essential for lymphocyte homing (Springer, T.A, 1990; Holzmann, B. and Weissman, I.L., 1989), embryogenesis and histogenesis (Darribière, T. et al., 1990), leukocyte activation (Davis, L.S. et al., 1990;), cytotoxic T lymphocyte activity (Clayberger, C. et al., 1987; 1990; Shimizu, Y. et al., 1989), and lympho-hemopoiesis (Miyake, K. et al., 1991).

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Abbreviations

COL :

Collagen;

ECM :

Extracellular Matrix;

FN :

Fibronectin;

ICAM-1 :

Intercellular Adhesion Molecule-1;

LFA-1 :

Leukocyte Function-associated Antigen-1;

LN :

Laminin;

RGD :

Arginine-Glycine-Aspartic Acid Sequence;

VCAM-1 :

Vascular Cell Adhesion Molecule-1;

VLA :

Very Late Activation Antigen

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Authors and Affiliations

  1. Servicio de Inmunologia Hospital de la Princesa, Universidad Autónoma de Madrid, c/ Diego de León, n° 62, 28006, Madrid, Spain

    Francisco Sánchez-Madrid, Alicia G. Arroyo, Miguel R. Campanero & Paloma Sánchez-Mateos

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  1. Francisco Sánchez-Madrid
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  2. Alicia G. Arroyo
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  3. Miguel R. Campanero
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  4. Paloma Sánchez-Mateos
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Editors and Affiliations

  1. Dana-Farber Cancer Institute, Boston, Massachusetts, USA

    Martin E. Hemler

  2. Roswell Park Cancer Institute, Buffalo, New York, USA

    Enrico Mihich

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© 1993 Plenum Press, New York

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Sánchez-Madrid, F., Arroyo, A.G., Campanero, M.R., Sánchez-Mateos, P. (1993). Regulation of β1 Integrin-Mediated Adhesive Functions. In: Hemler, M.E., Mihich, E. (eds) Cell Adhesion Molecules. Pezcoller Foundation Symposia, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2830-2_5

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  • DOI: https://doi.org/10.1007/978-1-4615-2830-2_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-44496-8

  • Online ISBN: 978-1-4615-2830-2

  • eBook Packages: Springer Book Archive

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