Abstract
Fibronectiins (FNs) are a set of extracellular proteins found in the extracellular matrix and in blood plasma which are involved in multiple functions, including cell adhesion and migration during development, hemostasis and thrombosis, or wound healing (see Hynes, 1990 for recent review). FNs comprise several isoforms, generated by alternative splicing of a single RNA transcript. Three sites of alternative splicing have been describes: EIIIA, EIIIB, and V segments (sometimes called EDA, EDB and IIICS). EIIIA and EIIIB can be completely included or excluded, while the V segment can be partially or totally included, depending on the splice site used (Figure 1).
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Abbreviations
- FN :
-
Fibronectin;
- pFN :
-
Plasma Fibronectin;
- cFN :
-
Cellular Fibronectin;
- neo R gene :
-
Neomycine Phosphotransferase Gene, conferring resistance to G418;
- pgk-neo R :
-
Neo gene under the control of the mouse phosphoglycerate kinase promoter;
- pMC1neo R :
-
Neo gene under the control of Herpes Simplex virus thymidine kinase promoter, and an enhancer from a mutant polyoma virus strain;
- TK :
-
Thymidine Kinase Gene;
- pgk-TK :
-
Thymidine Kinase Gene under the control of the mouse phosphoglycerate kinase promoter;
- ES cells :
-
Embryonic Stem Cells
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© 1993 Plenum Press, New York
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Georges, E.N., George, E.L., Rayburn, H., Hynes, R.O. (1993). Fibronectin Mutations in Mice. In: Hemler, M.E., Mihich, E. (eds) Cell Adhesion Molecules. Pezcoller Foundation Symposia, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2830-2_3
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DOI: https://doi.org/10.1007/978-1-4615-2830-2_3
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